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Ptpa Gene Detail
Summary
  • Symbol
    Ptpa
  • Name
    protein phosphatase 2 protein activator
  • Synonyms
    2610042B21Rik, MGC:60706, MGC:7129, Ppp2r4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346006
    NCBI Gene: 110854
  • Gene Overview
    MyGene.info: PTPA
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:30416050-30447807 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 21.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    187 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346006
protein coding gene Chr2:30416039-30447807 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025569
protein coding gene Chr2:28642426-28676061 (+)
A/J MGP_AJ_G0025547
protein coding gene Chr2:27502875-27534332 (+)
AKR/J MGP_AKRJ_G0025516
protein coding gene Chr2:28436189-28471527 (+)
BALB/cJ MGP_BALBcJ_G0025543
protein coding gene Chr2:27628824-27661456 (+)
C3H/HeJ MGP_C3HHeJ_G0025304
protein coding gene Chr2:28367032-28402842 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025988
protein coding gene Chr2:29582059-29619986 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023396
protein coding gene Chr2:26278301-26310566 (+)
CAST/EiJ MGP_CASTEiJ_G0024766
protein coding gene Chr2:28266424-28301531 (+)
CBA/J MGP_CBAJ_G0025281
protein coding gene Chr2:30587227-30631961 (+)
DBA/2J MGP_DBA2J_G0025414
protein coding gene Chr2:27291342-27322787 (+)
FVB/NJ MGP_FVBNJ_G0025377
protein coding gene Chr2:27111341-27143159 (+)
LP/J MGP_LPJ_G0025500
protein coding gene Chr2:28549758-28585180 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025407
protein coding gene Chr2:30468960-30502705 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026046
protein coding gene Chr2:28350796-28383573 (+)
PWK/PhJ MGP_PWKPhJ_G0024513
protein coding gene Chr2:27131828-27166828 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024313
protein coding gene Chr2:28471775-28505786 (+)
WSB/EiJ MGP_WSBEiJ_G0024834
protein coding gene Chr2:28481539-28519202 (+)



Homology
more
  • Human Ortholog
    PTPA, protein phosphatase 2 phosphatase activator
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTPA, protein phosphatase 2 phosphatase activator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PP2A, PPP2R4, PR53
  • Links
    NCBI Gene ID: 5524
    neXtProt AC: NX_Q15257
    UniProt: Q15257

  • Chr Location
    9q34.11; chr9:129110949-129148946 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 110854 NCBI Gene Model | MGI Sequence Detail 31758 C57BL/6J ±  kb
transcript NM_001362733 RefSeq | MGI Sequence Detail 2583 C57BL/6  
polypeptide P58389 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 245
    cDNA 245

    Microarray probesets 4
Other
Accession IDs
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MGI:1923815, MGI:2139462, MGI:2139539
References
more
  • Summaries
    All 45
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:252307 Sents W, et al., PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development. Cancer Res. 2017 Dec 15;77(24):6825-6837

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory