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Gtf2h2
Gene Detail
 Symbol
Name
ID
Gtf2h2
general transcription factor II H, polypeptide 2
MGI:1345669
Synonyms 44kDa, basal transcription factor 2, p44 subunit, Btf2p44, p44
Feature Type protein coding gene
Genetic Map
Chromosome 13
53.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr13:100460218-100492579 bp, - strand
From VEGA annotation of GRCm38

  32362 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1159  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: TFIIH basal transcription factor complex, SSL1 subunit
Gene Tree: Gtf2h2

Human
homologs
Human Homolog GTF2H2, general transcription factor IIH, polypeptide 2, 44kDa
NCBI Gene ID 2966
neXtProt AC  NX_Q13888
Human Synonyms  BTF2, BTF2P44, p44, T-BTF2P44, TFIIH
Human Chr (Location)  5q13.2; chr5:71035124-71067689 (-)  GRCh38
Alleles
and
phenotypes
All alleles(18) : Gene trapped(16) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process ATP catabolic process, cellular response to DNA damage stimulus, ...
Component core TFIIH complex, holo TFIIH complex, ...
Function DNA-dependent ATPase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (252)    Tissues (161)    Images (33)
Theiler Stages: 2, 3, 4, 5, 17, 21, 22, 23, 28
Assay TypeResults
RNA in situ 237
RT-PCR 15
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(26) Genomic(11) cDNA(13) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000023202 (Evidence)
Ensembl Gene ModelENSMUSG00000021639 (Evidence)
Entrez Gene23894 (Evidence)
DFCITC1580220, TC1588773, TC1596462, TC1681601
DoTSDT.101355094, DT.101378585, DT.101378586, DT.101704127, DT.529783, DT.87050401, DT.97391571
NIA Mouse Gene IndexU035108
Consensus CDS ProjectCCDS26730.1
International Mouse Knockout Project StatusGtf2h2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023202 VEGA Gene Model | MGI Sequence Detail 32362 C57BL/6J ±  kb
transcript OTTMUST00000056141 VEGA | MGI Sequence Detail 1630 Not Applicable 
polypeptide OTTMUSP00000065112 VEGA | MGI Sequence Detail 398 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(10) UniProt(5)
Polymorphisms SNPs within 2kb(151 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007198 Ssl1-like
InterPro IPR004595 TFIIH C1-like domain
InterPro IPR012170 TFIIH subunit Ssl1/p44
InterPro IPR002035 von Willebrand factor, type A
InterPro IPR007087 Zinc finger, C2H2
Protein Ontology PR:000008318 general transcription factor IIH subunit 2
References (Earliest) J:57491 von Deimling F, et al., Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma. Hum Genet. 1999 Jul-Aug;105(1-2):17-27
(Latest) J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory