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Pcbp1 Gene Detail
Summary
  • Symbol
    Pcbp1
  • Name
    poly(rC) binding protein 1
  • Synonyms
    [a]CP-1, hnRNP E1, WBP17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345635
    NCBI Gene: 23983
  • Gene Overview
    MyGene.info: PCBP1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:86524492-86526321 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1830 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.72 cM, cytoband D1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PCBP1, poly(rC) binding protein 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PCBP1, poly(rC) binding protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-85, hnRNP-E1, hnRNP-X, HNRPE1, HNRPX
  • Links
    NCBI Gene ID: 5093
    neXtProt AC: NX_Q15365
    UniProt: Q15365

  • Chr Location
    2p13.3; chr2:70087453-70089203 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit reduced body weight. Mice homozygous for the allele exhibit embryonic lethality between E3.5 and E8.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022709 VEGA Gene Model | MGI Sequence Detail 1830 C57BL/6J ±  kb
    transcript OTTMUST00000054473 VEGA | MGI Sequence Detail 1830 Not Applicable  
    polypeptide OTTMUSP00000026004 VEGA | MGI Sequence Detail 356 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      14 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 246
      Genomic 1
      cDNA 245

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:57023 Makeyev AV, et al., A set of highly conserved RNA-binding proteins, alphaCP-1 and alphaCP-2, implicated in mRNA stabilization, are coexpressed from an intronless gene and its intron-containing paralog. J Biol Chem. 1999 Aug 27;274(35):24849-57
    • Latest
      J:244696 Ryu MS, et al., PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis. J Clin Invest. 2017 May 01;127(5):1786-1797

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory