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Pcbp1 Gene Detail
Summary
  • Symbol
    Pcbp1
  • Name
    poly(rC) binding protein 1
  • Synonyms
    [a]CP-1, hnRNP E1, WBP17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345635
    NCBI Gene: 23983
  • Gene Overview
    MyGene.info: PCBP1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:86524494-86526171 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.72 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345635
protein coding gene Chr6:86524492-86526321 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030978
protein coding gene Chr6:87816038-87817869 (-)
A/J MGP_AJ_G0030944
protein coding gene Chr6:84428893-84430724 (-)
AKR/J MGP_AKRJ_G0030875
protein coding gene Chr6:86874688-86876515 (-)
BALB/cJ MGP_BALBcJ_G0030957
protein coding gene Chr6:84441015-84442842 (-)
C3H/HeJ MGP_C3HHeJ_G0030753
protein coding gene Chr6:97590653-97592484 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031414
protein coding gene Chr6:90202360-90204189 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028598
protein coding gene Chr6:82603745-82605584 (-)
CAST/EiJ MGP_CASTEiJ_G0030066
protein coding gene Chr6:86944364-86946201 (-)
CBA/J MGP_CBAJ_G0030641
protein coding gene Chr6:93751134-93752965 (-)
DBA/2J MGP_DBA2J_G0030797
protein coding gene Chr6:83744535-83746366 (-)
FVB/NJ MGP_FVBNJ_G0030750
protein coding gene Chr6:82929429-82931260 (-)
LP/J MGP_LPJ_G0030874
protein coding gene Chr6:87855419-87857250 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030783
protein coding gene Chr6:97867871-97869702 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031441
protein coding gene Chr6:86714041-86715872 (-)
PWK/PhJ MGP_PWKPhJ_G0029781
protein coding gene Chr6:82688414-82690481 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029609
protein coding gene Chr6:85553990-85555820 (-)
WSB/EiJ MGP_WSBEiJ_G0030147
protein coding gene Chr6:87171486-87173315 (-)



Homology
more
  • Human Ortholog
    PCBP1, poly(rC) binding protein 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PCBP1, poly(rC) binding protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-85, hnRNP-E1, hnRNP-X, HNRPE1, HNRPX
  • Links
    NCBI Gene ID: 5093
    neXtProt AC: NX_Q15365
    UniProt: Q15365

  • Chr Location
    2p13.3; chr2:70087453-70089203 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit reduced body weight. Mice homozygous for the allele exhibit embryonic lethality between E3.5 and E8.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23983 NCBI Gene Model | MGI Sequence Detail 1678 C57BL/6J ±  kb
    transcript NM_011865 RefSeq | MGI Sequence Detail 1710 C57BL/6  
    polypeptide P60335 UniProt | EBI | MGI Sequence Detail 356 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 246
      Genomic 1
      cDNA 245

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:57023 Makeyev AV, et al., A set of highly conserved RNA-binding proteins, alphaCP-1 and alphaCP-2, implicated in mRNA stabilization, are coexpressed from an intronless gene and its intron-containing paralog. J Biol Chem. 1999 Aug 27;274(35):24849-57
    • Latest
      J:244696 Ryu MS, et al., PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis. J Clin Invest. 2017 May 01;127(5):1786-1797

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory