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Mars Gene Detail
Summary
  • Symbol
    Mars
  • Name
    methionine-tRNA synthetase
  • Synonyms
    methionine tRNA ligase, methionyl-tRNA synthetase, MetRS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345633
    NCBI Gene: 216443
  • Gene Overview
    MyGene.info: MARS
Location & Maps
more
  • Sequence Map
    Chr10:127296221-127311786 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15566 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MARS, methionyl-tRNA synthetase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MARS, methionyl-tRNA synthetase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMT2U, ILFS2, ILLD, METRS, MRS, MTRNS, SPG70
  • Links
    NCBI Gene ID: 4141
    neXtProt AC: NX_P56192

  • Chr Location
    12q13.3; chr12:57487953-57516655 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 90878
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MARS
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human MARS associations

Human Disease Mouse Models
       Charcot-Marie-Tooth Disease, Axonal, Type 2u; CMT2U   OMIM: 616280
Interstitial Lung and Liver Disease; ILLD   OMIM: 615486
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032541 VEGA Gene Model | MGI Sequence Detail 15566 C57BL/6J ±  kb
transcript OTTMUST00000080974 VEGA | MGI Sequence Detail 2939 Not Applicable  
polypeptide OTTMUSP00000043200 VEGA | MGI Sequence Detail 902 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    123 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 124
    Genomic 1
    cDNA 123

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:57108 Ubeda M, et al., CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability. Biochem Biophys Res Commun. 1999 Aug 19;262(1):31-8
  • Latest
    J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory