Mars1 MGI Mouse Gene Detail - MGI:1345633 - methionine-tRNA synthetase 1

Symbol

Mars1
Name

methionine-tRNA synthetase 1
Synonyms

Mars, methionine tRNA ligase, methionyl-tRNA synthetase, MetRS

Feature Type

protein coding gene
IDs

MGI:1345633
NCBI Gene: 216443
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:127132090-127147655 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 74.50 cM
Mapping Data

1 experiment

SNPs within 2kb

123 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345633	protein coding gene	Chr10:127132090-127147655 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017817	protein coding gene	Chr10:130886587-130902092 (-)
A/J	MGP_AJ_G0017792	protein coding gene	Chr10:125641580-125657031 (-)
AKR/J	MGP_AKRJ_G0017755	protein coding gene	Chr10:129357618-129373055 (-)
BALB/cJ	MGP_BALBcJ_G0017756	protein coding gene	Chr10:126053380-126069529 (-)
C3H/HeJ	MGP_C3HHeJ_G0017580	protein coding gene	Chr10:129508782-129524327 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018211	protein coding gene	Chr10:135322419-135339620 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015891	protein coding gene	Chr10:119650224-119665964 (-)
CAST/EiJ	MGP_CASTEiJ_G0017140	protein coding gene	Chr10:130167514-130183543 (-)
CBA/J	MGP_CBAJ_G0017549	protein coding gene	Chr10:140773915-140789182 (-)
DBA/2J	MGP_DBA2J_G0017655	protein coding gene	Chr10:124734053-124749506 (-)
FVB/NJ	MGP_FVBNJ_G0017650	protein coding gene	Chr10:123674664-123690748 (-)
LP/J	MGP_LPJ_G0017729	protein coding gene	Chr10:131456775-131473521 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017678	protein coding gene	Chr10:143477400-143492876 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018251	protein coding gene	Chr10:129422318-129437871 (-)
PWK/PhJ	MGP_PWKPhJ_G0016925	protein coding gene	Chr10:124937192-124953035 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016717	protein coding gene	Chr10:128461184-128476267 (-)
WSB/EiJ	MGP_WSBEiJ_G0017201	protein coding gene	Chr10:129652516-129670900 (-)

Human Ortholog

MARS1, methionyl-tRNA synthetase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MARS1, methionyl-tRNA synthetase 1
Synonyms

CMT2U, ILFS2, ILLD, MARS, METRS, MRS, MTRNS, SPG70, TTD9
Links

HGNC:6898

NCBI Gene ID: 4141

neXtProt AC: NX_P56192

UniProt: P56192
Chr Location

12q13.3; chr12:57475445-57517569 (+) GRCh38

MGI Vertebrate Homology

Mars1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MARS1
Gene Tree

Mars1

Diseases

3 with human MARS1 associations

				Human Disease	Mouse Models
				Charcot-Marie-Tooth disease axonal type 2U IDs Charcot-Marie-Tooth disease axonal type 2U DOID:0110173 ICD10CM:G60.0 OMIM:616280 ORDO:397735
				hereditary spastic paraplegia 70 IDs hereditary spastic paraplegia 70 DOID:0070454 OMIM:620323
				trichothiodystrophy IDs trichothiodystrophy DOID:0111866 MESH:D054463 NCI:C4924 OMIM:PS601675 ORDO:33364 UMLS_CUI:C1955934

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotype references

All Mutations and Alleles

16
Endonuclease-mediated

3
Gene trapped

10
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available

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All GO Annotations

32
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

95
cDNA Data

124
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mars1

ZFIN mars1

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All Sequences

73
RefSeq

8
UniProt

3
CCDS

CCDS24237.1, CCDS48716.1

Ensembl

ENSMUSG00000040354 (Evidence)
NCBI Gene

216443

			Length	Strain/Species	Flank
genomic	216443	NCBI Gene Model \| MGI Sequence Detail	15566	C57BL/6J	± kb
transcript	NM_001171582	RefSeq \| MGI Sequence Detail	2972	C57BL/6
polypeptide	Q68FL6	UniProt \| EBI \| MGI Sequence Detail	902	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010190 methionine--tRNA ligase, cytoplasmic

(term hierarchy)
EC

6.1.1.10
InterPro Domains

IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site

IPR004046 Glutathione S-transferase, C-terminal

IPR036282 Glutathione S-transferase, C-terminal domain superfamily

IPR010987 Glutathione S-transferase, C-terminal-like

IPR041598 Methionine--tRNA ligase, N-terminal

IPR023458 Methionine-tRNA ligase, type 1

IPR033911 Methioninyl-tRNA synthetase core domain

IPR015413 Methionyl/Leucyl tRNA synthetase

IPR014758 Methionyl-tRNA synthetase

IPR041872 Methionyl-tRNA synthetase, anticodon-binding domain

IPR029038 Methionyl-tRNA synthetase, Zn-domain

IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

IPR009068 uS15/NS1, RNA-binding domain superfamily

IPR000738 WHEP-TRS domain

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All nucleic 126

Genomic 1

cDNA 124

Primer pair 1

Microarray probesets 3

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 11
Earliest

J:57108 Ubeda M, et al., CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability. Biochem Biophys Res Commun. 1999 Aug 19;262(1):31-8
Latest

J:342871 Xiang J, et al., ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment. Cells. 2023 Nov 16;12(22)

TSS for Mars1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99767	Chr10:127147609-127147632 (-)	34 bp
Tssr99766	Chr10:127147486-127147591 (-)	116 bp
Tssr99765	Chr10:127138676-127138681 (-)	8,976 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23