About   Help   FAQ
Mars Gene Detail
Summary
  • Symbol
    Mars
  • Name
    methionine-tRNA synthetase
  • Synonyms
    methionine tRNA ligase, methionyl-tRNA synthetase, MetRS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345633
    NCBI Gene: 216443
  • Gene Overview
    MyGene.info: MARS
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127296221-127311786 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    123 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345633
protein coding gene Chr10:127296221-127311786 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017817
protein coding gene Chr10:130886587-130902092 (-)
A/J MGP_AJ_G0017792
protein coding gene Chr10:125641580-125657031 (-)
AKR/J MGP_AKRJ_G0017755
protein coding gene Chr10:129357618-129373055 (-)
BALB/cJ MGP_BALBcJ_G0017756
protein coding gene Chr10:126053380-126069529 (-)
C3H/HeJ MGP_C3HHeJ_G0017580
protein coding gene Chr10:129508782-129524327 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018211
protein coding gene Chr10:135322419-135339620 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015891
protein coding gene Chr10:119650224-119665964 (-)
CAST/EiJ MGP_CASTEiJ_G0017140
protein coding gene Chr10:130167514-130183543 (-)
CBA/J MGP_CBAJ_G0017549
protein coding gene Chr10:140773915-140789182 (-)
DBA/2J MGP_DBA2J_G0017655
protein coding gene Chr10:124734053-124749506 (-)
FVB/NJ MGP_FVBNJ_G0017650
protein coding gene Chr10:123674664-123690748 (-)
LP/J MGP_LPJ_G0017729
protein coding gene Chr10:131456775-131473521 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017678
protein coding gene Chr10:143477400-143492876 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018251
protein coding gene Chr10:129422318-129437871 (-)
PWK/PhJ MGP_PWKPhJ_G0016925
protein coding gene Chr10:124937192-124953035 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016717
protein coding gene Chr10:128461184-128476267 (-)
WSB/EiJ MGP_WSBEiJ_G0017201
protein coding gene Chr10:129652516-129670900 (-)



Homology
more
  • Human Ortholog
    MARS, methionyl-tRNA synthetase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MARS, methionyl-tRNA synthetase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMT2U, ILFS2, ILLD, METRS, MRS, MTRNS, SPG70
  • Links
    NCBI Gene ID: 4141
    neXtProt AC: NX_P56192
    UniProt: P56192

  • Chr Location
    12q13.3; chr12:57487953-57516655 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 90878
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MARS
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MARS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 216443 NCBI Gene Model | MGI Sequence Detail 15566 C57BL/6J ±  kb
transcript NM_001171582 RefSeq | MGI Sequence Detail 2972 C57BL/6  
polypeptide Q68FL6 UniProt | EBI | MGI Sequence Detail 902 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 125
    Genomic 1
    cDNA 124

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 6
  • Earliest
    J:57108 Ubeda M, et al., CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability. Biochem Biophys Res Commun. 1999 Aug 19;262(1):31-8
  • Latest
    J:248509 Alvarez-Castelao B, et al., Cell-type-specific metabolic labeling of nascent proteomes in vivo. Nat Biotechnol. 2017 Dec;35(12):1196-1201

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory