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Rhof Gene Detail
Summary
  • Symbol
    Rhof
  • Name
    ras homolog family member F (in filopodia)
  • Synonyms
    Arhf, Ifld1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345629
    NCBI Gene: 23912
Location & Maps
more
  • Sequence Map
    Chr5:123103044-123132692 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29649 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 62.77 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RHOF, ras homolog family member F, filopodia associated
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RHOF, ras homolog family member F, filopodia associated
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARHF, RIF
  • Links
    NCBI Gene ID: 54509
    neXtProt AC: NX_Q9HBH0

  • Chr Location
    12q24.31; chr12:121777754-121793688 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Rhof
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit macrothrombocytopenia without an effect on filopodia generation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030767 VEGA Gene Model | MGI Sequence Detail 29649 C57BL/6J ±  kb
transcript OTTMUST00000079290 VEGA | MGI Sequence Detail 4306 Not Applicable  
polypeptide OTTMUSP00000042277 VEGA | MGI Sequence Detail 211 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    103 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013980 rho-related GTP-binding protein RhoF
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 22
    cDNA 22

    Microarray probesets 2
Other
Accession IDs
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MGI:2140981, MGI:2141105
References
more
  • Summaries
    All 27
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:42314 Klingenspor M, et al., Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics. J Biol Chem. 1999 Aug 13;274(33):23078-84
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory