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Slc25a1 Gene Detail
Summary
  • Symbol
    Slc25a1
  • Name
    solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
  • Synonyms
    1300019P08Rik, 2610100G11Rik, Dgsj, Slc20a3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345283
    NCBI Gene: 13358
  • Gene Overview
    MyGene.info: SLC25A1
Location & Maps
more
  • Sequence Map
    Chr16:17925211-17928219 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3009 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC25A1, solute carrier family 25 member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC25A1, solute carrier family 25 member 1
    Orthology source: HGNC
  • Synonyms
    CTP, D2L2AD, SEA, SLC20A3
  • Links
    NCBI Gene ID: 6576
    neXtProt AC: NX_P53007

  • Chr Location
    22q11.21; chr22:19175575-19178863 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SLC25A1 associations

Human Disease Mouse Models
       Combined D-2- and L-2-Hydroxyglutaric Aciduria; D2L2AD   OMIM: 615182
Click on a disease name to see all genes associated with that disease.

  • References
    11 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotype references
  • All Mutations and Alleles
    17
  • Gene trapped
    3
  • Targeted
    14
  • Genomic Mutations
    10 involving Slc25a1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026786 VEGA Gene Model | MGI Sequence Detail 3009 C57BL/6J ±  kb
transcript OTTMUST00000066236 VEGA | MGI Sequence Detail 1678 Not Applicable  
polypeptide OTTMUSP00000033168 VEGA | MGI Sequence Detail 311 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015004 tricarboxylate transport protein, mitochondrial
  • InterPro Domains
    IPR023395 Mitochondrial carrier domain
    IPR002067 Mitochondrial carrier protein
    IPR018108 Mitochondrial substrate/solute carrier
Molecular
Reagents
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  • All nucleic 152
    Genomic 21
    cDNA 128
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
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MGI:1203504, MGI:1915693, MGI:1924027, MGI:2146385, MGI:892007
References
more
  • Summaries
    All 49
    Developmental Gene Expression 6
    Diseases 11
    Gene Ontology 7
    Phenotypes 44
  • Earliest
    J:38193 Galili N, et al., A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region. (Correction: vol. 7(4):399). Genome Res. 1997 Jan;7(1):17-26
  • Latest
    J:213451 Karpinski BA, et al., Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome. Dis Model Mech. 2014 Feb;7(2):245-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory