About   Help   FAQ
Slc25a1 Gene Detail
Summary
  • Symbol
    Slc25a1
  • Name
    solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
  • Synonyms
    1300019P08Rik, 2610100G11Rik, Dgsj, Slc20a3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345283
    NCBI Gene: 13358
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17743087-17746083 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.11 cM, cytoband B1
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345283
 protein coding gene Chr16:17743075-17746083 (-)
129S1/SvImJ ENSMUSG00200042445
 protein coding gene Chr16:14739656-14742652 (-)
A/J ENSMUSG00195031521
 protein coding gene Chr16:14296950-14299946 (-)
AKR/J ENSMUSG00220045446
 protein coding gene Chr16:14613203-14616199 (-)
BALB/cJ ENSMUSG00180029816
 protein coding gene Chr16:14538187-14541183 (-)
C3H/HeJ ENSMUSG00175049756
 protein coding gene Chr16:14683193-14686189 (-)
C57BL/6NJ ENSMUSG00215040520
 protein coding gene Chr16:14404312-14407308 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020534
 protein coding gene Chr16:14418916-14421910 (-)
CAST/EiJ ENSTCUG00005041429
 protein coding gene Chr16:14621666-14624662 (-)
CBA/J ENSMUSG00210046819
 protein coding gene Chr16:14699518-14702514 (-)
DBA/2J ENSMUSG00185030054
 protein coding gene Chr16:14645667-14648663 (-)
FVB/NJ ENSMUSG00205043847
 protein coding gene Chr16:14653288-14656284 (-)
JF1/MsJ ENSUMUG00000051902
 protein coding gene Chr16:14736053-14739057 (-)
LP/J ENSMUSG00230042855
 protein coding gene Chr16:17223530-17226526 (-)
NOD/ShiLtJ ENSMUSG00190048645
 protein coding gene Chr16:14785571-14788567 (-)
NZO/HlLtJ ENSMUSG00225036895
 protein coding gene Chr16:20469371-20472367 (-)
PWK/PhJ ENSLUMG00010041473
 protein coding gene Chr16:14609864-14612866 (-)
SPRET/EiJ ENSMSPG00010040088
 protein coding gene Chr16:14627488-14630485 (-)
WSB/EiJ ENSIUOG00005036128
 protein coding gene Chr16:14779641-14782637 (-)



Homology
more
  • Human Ortholog
    SLC25A1, solute carrier family 25 member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A1, solute carrier family 25 member 1
  • Synonyms
    CIC, CMS23, CTP, D2L2AD, SEA, SLC20A3
  • Links
    NCBI Gene ID: 6576
    UniProt: P53007

  • Chr Location
    22q11.21; chr22:19175575-19178788 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human SLC25A1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    171 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    54
  • cDNA Data
    128
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003528 Ensembl Gene Model | MGI Sequence Detail 2997 C57BL/6J ±  kb
    transcript ENSMUST00000003622 Ensembl | MGI Sequence Detail 1666 Not Applicable  
    polypeptide ENSMUSP00000003622 Ensembl | MGI Sequence Detail 311 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000015004 tricarboxylate transport protein, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR002067 Mitochondrial carrier protein
      IPR023395 Mitochondrial carrier protein domain superfamily
      IPR018108 Mitochondrial carrier protein, transmembrane region
      IPR049563 Tricarboxylate transport protein-like
    • GlyGen
      Q8JZU2 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 155
      Genomic 21
      cDNA 129
      Primer pair 5
      Antibodies 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1203504, MGI:1915693, MGI:1924027, MGI:2146385, MGI:892007
    References
    more
    • Summaries
      All 224
      Developmental Gene Expression 12
      Diseases 6
      Gene Ontology 13
      Phenotypes 171
    • Earliest
      J:38193 Galili N, et al., A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region. (Correction: vol. 7(4):399). Genome Res. 1997 Jan;7(1):17-26
    • Latest
      J:392464 Wynne M, et al., Suppressive genetic interactions between haploinsufficient mitochondrial genes encoded in the 22q11.2 microdeletion locus define brain and cardiac phenotypes. Hum Mol Genet. 2026 Aug 10;35(17)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory