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Slc30a4 Gene Detail
Summary
  • Symbol
    Slc30a4
  • Name
    solute carrier family 30 (zinc transporter), member 4
  • Synonyms
    Znt4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345282
    NCBI Gene: 22785
  • Gene Overview
    MyGene.info: SLC30A4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:122681233-122702663 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21431 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 60.65 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLC30A4, solute carrier family 30 member 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC30A4, solute carrier family 30 member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    znT-4, ZNT4
  • Links
    NCBI Gene ID: 7782
    neXtProt AC: NX_O14863
    UniProt: O14863

  • Chr Location
    15q11.2-q21.3; chr15:45479613-45523685 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant dams produce zinc-deficient milk that is lethal to all nursing pups. Pleiotropic defects observed in mutant males and females include otolith degeneration, impaired motor coordination, alopecia, and dermatitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015670 VEGA Gene Model | MGI Sequence Detail 21431 C57BL/6J ±  kb
    transcript OTTMUST00000037230 VEGA | MGI Sequence Detail 5458 Not Applicable  
    polypeptide OTTMUSP00000016681 VEGA | MGI Sequence Detail 430 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      127 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 3
      cDNA 69
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11815, MGI:1196348, MGI:96792
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:230588 McCormick NH, et al., ZnT4 (SLC30A4)-null ("lethal milk") mice have defects in mammary gland secretion and hallmarks of precocious involution during lactation. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 1;310(1):R33-40

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory