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Slc30a4
Gene Detail
 Symbol
Name
ID
Slc30a4
solute carrier family 30 (zinc transporter), member 4
MGI:1345282
Synonyms Znt4
Feature Type protein coding gene
Genetic Map
Chromosome 2
60.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:122681233-122702663 bp, - strand
From VEGA annotation of GRCm38

  21431 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74984  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cation efflux protein
Gene Tree: Slc30a4

Human
homologs
Human Homolog SLC30A4, solute carrier family 30 (zinc transporter), member 4
NCBI Gene ID 7782
neXtProt AC  NX_O14863
Human Synonyms  ZNT4
Human Chr (Location)  15q11.2-q21.3; chr15:45482478-45522807 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant dams produce zinc-deficient milk that is lethal to all nursing pups. Pleiotropic defects observed in mutant males and females include otolith degeneration, impaired motor coordination, alopecia, and dermatitis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cation transport, divalent inorganic cation transport, ...
Component cytoplasm, cytoplasmic membrane-bounded vesicle, ...
Function cation transmembrane transporter activity, zinc ion transmembrane transporter activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (10)    Tissues (3)    Images (5)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 4
RT-PCR 6
cDNA source data(69)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(74) Genomic(3) cDNA(69) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000015670 (Evidence)
Ensembl Gene ModelENSMUSG00000005802 (Evidence)
Entrez Gene22785 (Evidence)
UniGene27801
DFCITC1631525, TC1638683
DoTSDT.101363085, DT.110651550, DT.530102
NIA Mouse Gene IndexU023280
Consensus CDS ProjectCCDS16667.1, CCDS71131.1
International Mouse Knockout Project StatusSlc30a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015670 VEGA Gene Model | MGI Sequence Detail 21431 C57BL/6J ±  kb
transcript OTTMUST00000037230 VEGA | MGI Sequence Detail 5458 Not Applicable 
polypeptide OTTMUSP00000016681 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002524 Cation efflux protein
InterPro IPR027469 Cation efflux protein transmembrane domain
Protein Ontology PR:000015077 zinc transporter 4
References (Earliest) J:30724 Dickie MM, lm. Mouse News Lett. 1969;41:30-1
(Latest) J:191356 McCormick NH, et al., ZnT4 provides zinc to zinc-dependent proteins in the trans-Golgi network critical for cell function and Zn export in mammary epithelial cells. Am J Physiol Cell Physiol. 2012 Aug 1;303(3):C291-7
All references(46)
Other
accession IDs
MGD-MRK-11815, MGI:1196348, MGI:96792

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory