About   Help   FAQ
Slc30a4
Gene Detail
Symbol

Name
ID
Slc30a4
solute carrier family 30 (zinc transporter), member 4
MGI:1345282
Synonyms
Znt4
Feature Type
protein coding gene
Genetic Map
Chromosome 2
60.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:122681233-122702663 bp, - strand
From VEGA annotation of GRCm38

  21431 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74984  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC30A4
Protein SuperFamily: cation efflux protein
Gene Tree: Slc30a4

Human
homologs
SLC30A4, solute carrier family 30 (zinc transporter), member 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7782
neXtProt AC: NX_O14863

Human Synonyms: ZNT4

Human Chr (Location): 15q11.2-q21.3; chr15:45482478-45523669 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant dams produce zinc-deficient milk that is lethal to all nursing pups. Pleiotropic defects observed in mutant males and females include otolith degeneration, impaired motor coordination, alopecia, and dermatitis.
 
Interactions
Slc30a4 interacts with 439 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (10)    Tissues (3)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
RT-PCR 6
cDNA source data(69)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc30a4 ; ZFIN slc30a4    NEW 
Molecular
reagents
All nucleic(74) Genomic(3) cDNA(69) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000015670 (Evidence)
Ensembl Gene Model ENSMUSG00000005802 (Evidence)
Entrez Gene 22785 (Evidence)
UniGene 27801
DFCI TC1631525, TC1638683
DoTS DT.101363085, DT.110651550, DT.530102
NIA Mouse Gene Index U023280
Consensus CDS Project CCDS16667.1, CCDS71131.1
International Mouse Phenotyping Consortium Status Slc30a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015670 VEGA Gene Model | MGI Sequence Detail 21431 C57BL/6J ±  kb
transcript OTTMUST00000037230 VEGA | MGI Sequence Detail 5458 Not Applicable 
polypeptide OTTMUSP00000016681 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002524 Cation efflux protein
InterPro IPR027469 Cation efflux protein transmembrane domain
Protein Ontology PR:000015077 zinc transporter 4
References
(Earliest) J:30724 Dickie MM, lm. Mouse News Lett. 1969;41:30-1
(Latest) J:191356 McCormick NH, et al., ZnT4 provides zinc to zinc-dependent proteins in the trans-Golgi network critical for cell function and Zn export in mammary epithelial cells. Am J Physiol Cell Physiol. 2012 Aug 1;303(3):C291-7
All references(45)
Other
accession IDs
MGD-MRK-11815, MGI:1196348, MGI:96792

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory