Slc11a2
Gene Detail

Symbol Name ID

Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 MGI:1345279

Synonyms

DCT1, DMT1, microcytic anemia, viable anaemia, Nramp2, van

Feature Type

protein coding gene

Genetic Map

Chromosome 15

56.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr15:100387898-100425072 bp, - strand From VEGA annotation of GRCm38   37175 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: divalent metal ion transporter, NRAMP type
Gene Tree: Slc11a2

Human homologs

Human Homolog		SLC11A2, solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
NCBI Gene ID		4891
neXtProt AC		NX_P49281
Human Synonyms		DCT1, DMT1, NRAMP2
Human Chr (Location)		12q13; chr12:51373566-51422118 (-)  GRCh37.p13
Disease Associations		(1) Diseases Associated with Human SLC11A2

Alleles and phenotypes

All alleles(14) : Targeted(4) Gene trapped(8) Spontaneous(2)
 

Homozygotes for a spontaneous mutation exhibit microcytic, hypochromic anemia associated with impaired intestinal iron absorption and erythroblast iron uptake. Mutants have reduced viability and fertility.

 

Gene Ontology (GO) classifications

All GO classifications: (102 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, cadmium ion transmembrane transport, ...
Component	apical part of cell, apical plasma membrane, ...
Function	cadmium ion binding, cadmium ion transmembrane transporter activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (20)    Tissues (6)    Images (4)
Theiler Stages: 15, 23, 26, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	1
Western blot	8
RT-PCR	4

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(13) Primer pair(4) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000033264 (Evidence)
Ensembl Gene Model	ENSMUSG00000023030 (Evidence)
Entrez Gene	18174 (Evidence)
DoTS	DT.101330041, DT.101384031, DT.110788752, DT.110788756, DT.87072375, DT.94227361, DT.97353910, DT.99858807
NIA Mouse Gene Index	U036662
Consensus CDS Project	CCDS37211.1, CCDS49733.1
International Mouse Knockout Project Status	Slc11a2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033264	VEGA Gene Model | MGI Sequence Detail	37175	C57BL/6J
transcript	OTTMUST00000083399	VEGA | MGI Sequence Detail	3025	Not Applicable
polypeptide	OTTMUSP00000044815	VEGA | MGI Sequence Detail	568	Not Applicable

All sequences(95) RefSeq(17) UniProt(6)

Polymorphisms

PCR(2) : SNPs within 2kb(361 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001046	Natural resistance-associated macrophage like
Protein Ontology	PR:000002993	natural resistance-associated macrophage protein 2

References

(Earliest) J:5167 Russell ES, et al., Characterization and genetic studies of microcytic anemia in house mouse. Blood. 1970 Jun;35(6):838-50
(Latest) J:205514 Anderson ER, et al., Intestinal HIF2alpha promotes tissue-iron accumulation in disorders of iron overload with anemia. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4922-30
All references(88)

Other accession IDs

MGD-MRK-12247, MGD-MRK-15380, MGD-MRK-24100, MGI:103229, MGI:96993