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Slc11a2 Gene Detail
Summary
  • Symbol
    Slc11a2
  • Name
    solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
  • Synonyms
    DCT1, DMT1, microcytic anemia, viable anaemia, Nramp2, van
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345279
    NCBI Gene: 18174
  • Gene Overview
    MyGene.info: SLC11A2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:100387898-100425072 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37175 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.29 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    SLC11A2, solute carrier family 11 member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC11A2, solute carrier family 11 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AHMIO1, DCT1, DMT1, NRAMP2
  • Links
    NCBI Gene ID: 4891
    neXtProt AC: NX_P49281
    UniProt: P49281

  • Chr Location
    12q13.12; chr12:50952263-51028335 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SLC11A2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 3 alleles in 7 genetic backgrounds
    6 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit microcytic, hypochromic anemia associated with impaired intestinal iron absorption and erythroblast iron uptake. Mutants have reduced viability and fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033264 VEGA Gene Model | MGI Sequence Detail 37175 C57BL/6J ±  kb
    transcript OTTMUST00000083399 VEGA | MGI Sequence Detail 3025 Not Applicable  
    polypeptide OTTMUSP00000044815 VEGA | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      361 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 14
      Primer pair 4
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12247, MGD-MRK-15380, MGD-MRK-24100, MGI:103229, MGI:96993
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 25
      Phenotypes 55
    • Earliest
      J:5167 Russell ES, et al., Characterization and genetic studies of microcytic anemia in house mouse. Blood. 1970 Jun;35(6):838-50
    • Latest
      J:262823 Kasowitz SD, et al., Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet. 2018 May;14(5):e1007412

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory