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Slc11a2 Gene Detail
Summary
  • Symbol
    Slc11a2
  • Name
    solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
  • Synonyms
    DCT1, DMT1, microcytic anemia, viable anaemia, Nramp2, van
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345279
    NCBI Gene: 18174
  • Gene Overview
    MyGene.info: SLC11A2
Location & Maps
more
  • Sequence Map
    Chr15:100387898-100425072 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      37175 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.29 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    SLC11A2, solute carrier family 11 member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC11A2, solute carrier family 11 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AHMIO1, DCT1, DMT1, NRAMP2
  • Links
    NCBI Gene ID: 4891
    neXtProt AC: NX_P49281

  • Chr Location
    12q13; chr12:50979410-51028335 (-)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with human SLC11A2 associations

Human Disease Mouse Models
       Anemia, Hypochromic Microcytic, with Iron Overload 1; AHMIO1   OMIM: 206100
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 3 alleles in 7 genetic backgrounds
    6 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Radiation induced
    2
  • Spontaneous
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Slc11a2
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Homozygotes for a spontaneous mutation exhibit microcytic, hypochromic anemia associated with impaired intestinal iron absorption and erythroblast iron uptake. Mutants have reduced viability and fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    90
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    20
  • Tissues
    8
  • cDNA Data
    13
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033264 VEGA Gene Model | MGI Sequence Detail 37175 C57BL/6J ±  kb
transcript OTTMUST00000083399 VEGA | MGI Sequence Detail 3025 Not Applicable  
polypeptide OTTMUSP00000044815 VEGA | MGI Sequence Detail 568 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    361 from dbSNP Build 142
  • PCR
    2
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000002993 natural resistance-associated macrophage protein 2
  • InterPro Domains
    IPR001046 NRAMP family
Molecular
Reagents
less
  • All nucleic 18
    cDNA 13
    Primer pair 4
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-12247, MGD-MRK-15380, MGD-MRK-24100, MGI:103229, MGI:96993
References
more
  • Summaries
    All 85
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 23
    Phenotypes 54
  • Earliest
    J:5167 Russell ES, et al., Characterization and genetic studies of microcytic anemia in house mouse. Blood. 1970 Jun;35(6):838-50
  • Latest
    J:228800 Shawki A, et al., Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese. Am J Physiol Gastrointest Liver Physiol. 2015 Oct 15;309(8):G635-47
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory