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Slc11a2
Gene Detail
 Symbol
Name
ID
Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
MGI:1345279
Synonyms DCT1, DMT1, microcytic anemia, viable anaemia, Nramp2, van
Feature Type protein coding gene
Genetic Map
Chromosome 15
56.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr15:100387898-100425072 bp, - strand
From VEGA annotation of GRCm38

  37175 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: divalent metal ion transporter, NRAMP type
Gene Tree: Slc11a2

Human
homologs
Human Homolog SLC11A2, solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
NCBI Gene ID 4891
neXtProt AC  NX_P49281
Human Synonyms  DCT1, DMT1, NRAMP2
Human Chr (Location)  12q13; chr12:50979783-51028335 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC11A2
Alleles
and
phenotypes
All alleles(14) : Targeted(4) Gene trapped(8) Spontaneous(2)
 
Homozygotes for a spontaneous mutation exhibit microcytic, hypochromic anemia associated with impaired intestinal iron absorption and erythroblast iron uptake. Mutants have reduced viability and fertility.
 
Gene Ontology
(GO)
classifications
All GO classifications: (102 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, cadmium ion transmembrane transport, ...
Component apical part of cell, apical plasma membrane, ...
Function cadmium ion binding, cadmium ion transmembrane transporter activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (20)    Tissues (6)    Images (4)
Theiler Stages: 15, 23, 26, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 1
Western blot 8
RT-PCR 4
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(18) cDNA(13) Primer pair(4) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000033264 (Evidence)
Ensembl Gene ModelENSMUSG00000023030 (Evidence)
Entrez Gene18174 (Evidence)
DoTSDT.101330041, DT.101384031, DT.110788752, DT.110788756, DT.87072375, DT.94227361, DT.97353910, DT.99858807
NIA Mouse Gene IndexU036662
Consensus CDS ProjectCCDS37211.1, CCDS49733.1
International Mouse Knockout Project StatusSlc11a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033264 VEGA Gene Model | MGI Sequence Detail 37175 C57BL/6J ±  kb
transcript OTTMUST00000083399 VEGA | MGI Sequence Detail 3025 Not Applicable 
polypeptide OTTMUSP00000044815 VEGA | MGI Sequence Detail 568 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(17) UniProt(6)
Polymorphisms PCR(2) : SNPs within 2kb(361 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001046 Natural resistance-associated macrophage like
Protein Ontology PR:000002993 natural resistance-associated macrophage protein 2
References (Earliest) J:5167 Russell ES, et al., Characterization and genetic studies of microcytic anemia in house mouse. Blood. 1970 Jun;35(6):838-50
(Latest) J:205514 Anderson ER, et al., Intestinal HIF2alpha promotes tissue-iron accumulation in disorders of iron overload with anemia. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4922-30
All references(88)
Other
accession IDs
MGD-MRK-12247, MGD-MRK-15380, MGD-MRK-24100, MGI:103229, MGI:96993

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory