Slc11a2
Gene Detail

Symbol

Name
ID

Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
MGI:1345279

Synonyms

DCT1, DMT1, microcytic anemia, viable anaemia, Nramp2, van

Feature Type

protein coding gene

Genetic Map

Chromosome 15
56.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr15:100387898-100425072 bp, - strand From VEGA annotation of GRCm38   37175 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:55471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: divalent metal ion transporter, NRAMP type
Gene Tree: Slc11a2

Human
homologs

Human Homolog		SLC11A2, solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
NCBI Gene ID		4891
neXtProt AC		NX_P49281
Human Synonyms		DCT1, DMT1, NRAMP2
Human Chr (Location)		12q13; chr12:50979783-51028335 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human SLC11A2

Mutations,
alleles, and
phenotypes

All mutations/alleles(15) : Gene trapped(8) Radiation induced(1) Spontaneous(2) Targeted(4)
Genomic Mutations involving Slc11a2 (1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for a spontaneous mutation exhibit microcytic, hypochromic anemia associated with impaired intestinal iron absorption and erythroblast iron uptake. Mutants have reduced viability and fertility.

 
Phenotype Images(2)

Interactions

Slc11a2 interacts with 314 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (107 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, cadmium ion transmembrane transport, ...
Component	apical part of cell, apical plasma membrane, ...
Function	cadmium ion binding, cadmium ion transmembrane transporter activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (20)    Tissues (8)    Images (4)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	7
RNA in situ	1
Western blot	8
RT-PCR	4

cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(18) cDNA(13) Primer pair(4) Other(1)
Microarray probesets(6)

Other database
links

VEGA Gene Model	OTTMUSG00000033264 (Evidence)
Ensembl Gene Model	ENSMUSG00000023030 (Evidence)
Entrez Gene	18174 (Evidence)
DoTS	DT.94227361, DT.87072375, DT.110788756, DT.110788752, DT.101384031, DT.101330041, DT.99858807, DT.97353910
NIA Mouse Gene Index	U036662
Consensus CDS Project	CCDS37211.1, CCDS49733.1
International Mouse Knockout Project Status	Slc11a2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033264	VEGA Gene Model | MGI Sequence Detail	37175	C57BL/6J
transcript	OTTMUST00000083399	VEGA | MGI Sequence Detail	3025	Not Applicable
polypeptide	OTTMUSP00000044815	VEGA | MGI Sequence Detail	568	Not Applicable

All sequences(100) RefSeq(17) UniProt(11)

Polymorphisms

PCR(2) : SNPs within 2kb(361 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001046	Natural resistance-associated macrophage like
Protein Ontology	PR:000002993	natural resistance-associated macrophage protein 2

References

(Earliest) J:5167 Russell ES, et al., Characterization and genetic studies of microcytic anemia in house mouse. Blood. 1970 Jun;35(6):838-50
(Latest) J:205514 Anderson ER, et al., Intestinal HIF2alpha promotes tissue-iron accumulation in disorders of iron overload with anemia. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4922-30
All references(88)

Other
accession IDs

MGD-MRK-12247, MGD-MRK-15380, MGD-MRK-24100, MGI:103229, MGI:96993