Blmh
Gene Detail

Symbol Name ID

Blmh bleomycin hydrolase MGI:1345186

Synonyms

MGC:36899, MGC:37104, MGC:39026

Feature Type

protein coding gene

Genetic Map

Chromosome 11

46.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:76924809-76987379 bp, + strand From VEGA annotation of GRCm38   62571 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Blmh ± 2 cM)

Protein SuperFamily: aminopeptidase C (bleomycin hydrolase)
Gene Tree: Blmh

Human ortholog

BLMH bleomycin hydrolase NCBI Gene ID 642
Human Synonyms: BH, BMH
Human Chr17:28575223-28619074 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human BLMH (1)

Alleles and phenotypes

All alleles(12) : Targeted(3) Gene trapped(9)
 

About one-third of homozygous null mutants die neonatally; survivors develop variably penetrant tail dermatitis and pulmonary fibrosis following bleomycin treatment.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	metabolic process, proteolysis, ...
Component	cytoplasm
Function	cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	1

cDNA source data(183)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(183) cDNA(183)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000006244 (Evidence)
Ensembl Gene Model	ENSMUSG00000020840 (Evidence)
Entrez Gene	104184 (Evidence)
UniGene	399785
DFCI	TC1573489, TC1589158, TC1679592, TC1730130
DoTS	DT.101387899, DT.102558967, DT.534590, DT.94241514
NIA Mouse Gene Index	U012971
EC	3.4.22.40
Consensus CDS Project	CCDS25073.1
International Mouse Knockout Project Status	Blmh

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006244	VEGA Gene Model | MGI Sequence Detail	62571	C57BL/6J
transcript	OTTMUST00000014100	VEGA | MGI Sequence Detail	2497	Not Applicable
polypeptide	OTTMUSP00000006555	VEGA | MGI Sequence Detail	455	Not Applicable

All sequences(78) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(277 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000169	Cysteine peptidase, cysteine active site
InterPro	IPR004134	Peptidase C1B, bleomycin hydrolase
Protein Ontology	PR:000004760	bleomycin hydrolase

References

(Earliest) J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)

Other accession IDs

MGI:2145940