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Blmh Gene Detail
Summary
  • Symbol
    Blmh
  • Name
    bleomycin hydrolase
  • Synonyms
    MGC:36899, MGC:37104, MGC:39026
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345186
    NCBI Gene: 104184
  • Gene Overview
    MyGene.info: BLMH
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:76945656-76987389 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.16 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    299 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345186
protein coding gene Chr11:76924809-76987389 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018741
protein coding gene Chr11:77807102-77850879 (+)
A/J MGP_AJ_G0018707
protein coding gene Chr11:74884568-74927289 (+)
AKR/J MGP_AKRJ_G0018677
protein coding gene Chr11:77153224-77195001 (+)
BALB/cJ MGP_BALBcJ_G0018681
protein coding gene Chr11:75266097-75308486 (+)
C3H/HeJ MGP_C3HHeJ_G0018494
protein coding gene Chr11:77173800-77216503 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019132
protein coding gene Chr11:80254175-80298914 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016767
protein coding gene Chr11:71855118-71914061 (+)
CAST/EiJ MGP_CASTEiJ_G0018048
protein coding gene Chr11:77569616-77617576 (+)
CBA/J MGP_CBAJ_G0018464
protein coding gene Chr11:83753253-83799576 (+)
DBA/2J MGP_DBA2J_G0018573
protein coding gene Chr11:74472699-74515480 (+)
FVB/NJ MGP_FVBNJ_G0018563
protein coding gene Chr11:74037717-74081244 (+)
LP/J MGP_LPJ_G0018644
protein coding gene Chr11:78411656-78454277 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018589
protein coding gene Chr11:84220785-84265570 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019172
protein coding gene Chr11:77368777-77410690 (+)
PWK/PhJ MGP_PWKPhJ_G0017819
protein coding gene Chr11:75194358-75259417 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017610
protein coding gene Chr11:76916425-76992095 (+)
WSB/EiJ MGP_WSBEiJ_G0018101
protein coding gene Chr11:77181205-77224512 (+)



Homology
more
  • Human Ortholog
    BLMH, bleomycin hydrolase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BLMH, bleomycin hydrolase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BH, BMH
  • Links
    NCBI Gene ID: 642
    neXtProt AC: NX_Q13867
    UniProt: Q13867

  • Chr Location
    17q11.2; chr17:30248195-30292166 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    2 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
About one-third of homozygous null mutants die neonatally; survivors develop variably penetrant tail dermatitis and pulmonary fibrosis following bleomycin treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104184 NCBI Gene Model | MGI Sequence Detail 41734 C57BL/6J ±  kb
    transcript NM_178645 RefSeq | MGI Sequence Detail 2355 C57BL/6  
    polypeptide Q8R016 UniProt | EBI | MGI Sequence Detail 455 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 188
      cDNA 188

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145940
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:219444 Suszynska-Zajczyk J, et al., Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease. Mol Genet Metab. 2014 Aug;112(4):339-46

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory