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Blmh Gene Detail
Summary
  • Symbol
    Blmh
  • Name
    bleomycin hydrolase
  • Synonyms
    MGC:36899, MGC:37104, MGC:39026
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345186
    NCBI Gene: 104184
  • Gene Overview
    MyGene.info: BLMH
Location & Maps
more
  • Sequence Map
    Chr11:76924809-76987379 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62571 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.16 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BLMH, bleomycin hydrolase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BLMH, bleomycin hydrolase
    Orthology source: HomoloGene
  • Synonyms
    BH, BMH
  • Links
    NCBI Gene ID: 642
    neXtProt AC: NX_Q13867

  • Chr Location
    17q11.2; chr17:30248195-30292166 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human BLMH associations

Human Disease Mouse Models
       Alzheimer Disease; AD   OMIM: 104300
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    2 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    9
  • Targeted
    4
  • Genomic Mutations
    2 involving Blmh
  • Incidental Mutations
About one-third of homozygous null mutants die neonatally; survivors develop variably penetrant tail dermatitis and pulmonary fibrosis following bleomycin treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006244 VEGA Gene Model | MGI Sequence Detail 62571 C57BL/6J ±  kb
transcript OTTMUST00000014100 VEGA | MGI Sequence Detail 2497 Not Applicable  
polypeptide OTTMUSP00000006555 VEGA | MGI Sequence Detail 455 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    337 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 187
    cDNA 187

    Microarray probesets 5
Other
Accession IDs
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MGI:2145940
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
  • Latest
    J:219444 Suszynska-Zajczyk J, et al., Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease. Mol Genet Metab. 2014 Aug;112(4):339-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory