About   Help   FAQ
Blmh
Gene Detail
Symbol

Name
ID
Blmh
bleomycin hydrolase
MGI:1345186
Synonyms
MGC:36899, MGC:37104, MGC:39026
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:76924809-76987379 bp, + strand
From VEGA annotation of GRCm38

  62571 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:330  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BLMH
Protein SuperFamily: aminopeptidase C (bleomycin hydrolase)
Gene Tree: Blmh

Human
homologs
BLMH, bleomycin hydrolase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 642
neXtProt AC: NX_Q13867

Human Synonyms: BH, BMH

Human Chr (Location): 17q11.2; chr17:30248195-30292166 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human BLMH

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(9) Targeted(4)
Genomic Mutations involving Blmh (1)
Incidental mutations (data from Mutagenetix , APF )
 
About one-third of homozygous null mutants die neonatally; survivors develop variably penetrant tail dermatitis and pulmonary fibrosis following bleomycin treatment.
 
Phenotype Images(2)
Interactions
Blmh interacts with 252 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process proteolysis, response to drug, ...
Component cytoplasm, extracellular exosome, ...
Function cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(187)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase blmh ; ZFIN blmh    NEW 
Molecular
reagents
All nucleic(187) cDNA(187)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000006244 (Evidence)
Ensembl Gene Model ENSMUSG00000020840 (Evidence)
Entrez Gene 104184 (Evidence)
UniGene 399785
DFCI TC1573489, TC1589158, TC1679592, TC1730130
DoTS DT.101387899, DT.94241514, DT.534590, DT.102558967
NIA Mouse Gene Index U012971
EC 3.4.22.40
Consensus CDS Project CCDS25073.1
International Mouse Phenotyping Consortium Status Blmh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006244 VEGA Gene Model | MGI Sequence Detail 62571 C57BL/6J ±  kb
transcript OTTMUST00000014100 VEGA | MGI Sequence Detail 2497 Not Applicable 
polypeptide OTTMUSP00000006555 VEGA | MGI Sequence Detail 455 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(374 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR004134 Peptidase C1B, bleomycin hydrolase
Protein Ontology PR:000004760 bleomycin hydrolase
References
(Earliest) J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
(Latest) J:219444 Suszynska-Zajczyk J, et al., Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease. Mol Genet Metab. 2014 Aug;112(4):339-46
All references(40)
Other
accession IDs
MGI:2145940

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory