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Tenm3 Gene Detail
Summary
  • Symbol
    Tenm3
  • Name
    teneurin transmembrane protein 3
  • Synonyms
    2610100B16Rik, mKIAA1455, Odz3, Ten-m3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345183
    NCBI Gene: 23965
  • Gene Overview
    MyGene.info: TENM3
Location & Maps
more
  • Sequence Map
    Chr8:48227682-48844026 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      616345 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TENM3, teneurin transmembrane protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TENM3, teneurin transmembrane protein 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MCOPCB9, ODZ3, ten-3, Ten-m3, TNM3
  • Links
    NCBI Gene ID: 55714
    neXtProt AC: NX_Q9P273

  • Chr Location
    4q35.1; chr4:182323984-182803024 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TENM3 associations

Human Disease Mouse Models
       Microphthalmia, Isolated, with Coloboma 9; MCOPCB9   OMIM: 615145
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    102
  • Chemically induced (other)
    1
  • Gene trapped
    97
  • Targeted
    4
  • Genomic Mutations
    1 involving Tenm3
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a null mutation display abnormal ipsilateral retinal ganglion cell projections and impaired performance in visually mediated behavioral tasks.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021119 VEGA Gene Model | MGI Sequence Detail 616345 C57BL/6J ±  kb
transcript OTTMUST00000049977 VEGA | MGI Sequence Detail 9242 Not Applicable  
polypeptide OTTMUSP00000023259 VEGA | MGI Sequence Detail 2715 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3551 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 16
    cDNA 10
    Primer pair 4
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGI:1917577
References
more
  • Summaries
    All 52
    Developmental Gene Expression 16
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:54528 Oohashi T, et al., Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues. J Cell Biol. 1999 May 3;145(3):563-77
  • Latest
    J:208462 Merlin S, et al., Deletion of Ten-m3 induces the formation of eye dominance domains in mouse visual cortex. Cereb Cortex. 2013 Apr;23(4):763-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory