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Aadat Gene Detail
Summary
  • Symbol
    Aadat
  • Name
    aminoadipate aminotransferase
  • Synonyms
    Kat2, KATII, Kyat2, mKat-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345167
    NCBI Gene: 23923
Location & Maps
more
  • Sequence Map
    Chr8:60505932-60545677 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39746 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 30.85 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AADAT, aminoadipate aminotransferase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    AADAT, aminoadipate aminotransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KAT2, KATII, KYAT2
  • Links
    NCBI Gene ID: 51166
    neXtProt AC: NX_Q8N5Z0

  • Chr Location
    4q33; chr4:170060222-170091699 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56540
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;2 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: AADAT
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Aadat
  • Incidental Mutations
Homozygous null mice are viable and display earlier eye opening and development of air righting and open field crossing responses, and transient hyperactivity and neuronal abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060946 VEGA Gene Model | MGI Sequence Detail 39746 C57BL/6J ±  kb
transcript OTTMUST00000148953 VEGA | MGI Sequence Detail 1597 Not Applicable  
polypeptide OTTMUSP00000077357 VEGA | MGI Sequence Detail 432 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    260 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000003525 kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
  • EC
  • InterPro Domains
    IPR004839 Aminotransferase, class I/classII
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Molecular
Reagents
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  • All nucleic 75
    cDNA 73
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142647
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:56834 Yu P, et al., Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease. Mamm Genome. 1999 Sep;10(9):845-52
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory