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Adam23 Gene Detail
Summary
  • Symbol
    Adam23
  • Name
    a disintegrin and metallopeptidase domain 23
  • Synonyms
    MDC3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345162
    NCBI Gene: 23792
  • Gene Overview
    MyGene.info: ADAM23
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr1:63445891-63596276 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      150386 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 32.31 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ADAM23, ADAM metallopeptidase domain 23
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAM23, ADAM metallopeptidase domain 23
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MDC3, MDC-3
  • Links
    NCBI Gene ID: 8745
    neXtProt AC: NX_O75077
    UniProt: O75077

  • Chr Location
    2q33.3; chr2:206443544-206621130 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 2826
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ADAM23
  • Gene Tree
    Adam23
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an insertional mutation that inactivates the gene are smaller than normal littermates, show delayed lung development, are lethal by postnatal day 14, and display severe tremor and ataxia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    298
  • Tissues
    92
  • cDNA Data
    34
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002497 VEGA Gene Model | MGI Sequence Detail 150386 C57BL/6J ±  kb
    transcript OTTMUST00000005207 VEGA | MGI Sequence Detail 2889 Not Applicable  
    polypeptide OTTMUSP00000067232 VEGA | MGI Sequence Detail 837 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      952 from dbSNP Build 142
    • PCR
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 1
      cDNA 36
      Primer pair 5
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138543
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 10
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/16/2018
    MGI 6.12     		The Jackson Laboratory