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Adam23
Gene Detail
Symbol

Name
ID
Adam23
a disintegrin and metallopeptidase domain 23
MGI:1345162
Synonyms
MDC3
Feature Type
protein coding gene
Genetic Map
Chromosome 1
32.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:63445891-63596276 bp, + strand
From VEGA annotation of GRCm38

  150386 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2826  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADAM23
Gene Tree: Adam23

Human
homologs
ADAM23, ADAM metallopeptidase domain 23
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8745
neXtProt AC: NX_O75077

Human Synonyms: MDC3, MDC-3

Human Chr (Location): 2q33; chr2:206443544-206621130 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(14) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for an insertional mutation that inactivates the gene are smaller than normal littermates, show delayed lung development, are lethal by postnatal day 14, and display severe tremor and ataxia.
 
Interactions
Adam23 interacts with 427 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell adhesion, proteolysis
Component extracellular region, integral component of membrane, ...
Function metalloendopeptidase activity, metallopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (265)    Tissues (77)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 128
RT-PCR 137
cDNA source data(32)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA ADAM23 ; Xenbase adam23 ; ZFIN adam23a    NEW 
Molecular
reagents
All nucleic(41) Genomic(1) cDNA(34) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000002497 (Evidence)
Ensembl Gene Model ENSMUSG00000025964 (Evidence)
Entrez Gene 23792 (Evidence)
UniGene 124892
DFCI TC1585418, TC1589694, TC1584131, TC1619244, TC1646741, TC1622598, TC1621882, TC1675751, TC1752685
DoTS DT.101172188, DT.101731756, DT.94135627, DT.102544546, DT.522764, DT.94337151, DT.91589794, DT.482874, DT.91387678
NIA Mouse Gene Index U000370
Consensus CDS Project CCDS14999.1, CCDS48279.1
International Mouse Phenotyping Consortium Status Adam23
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002497 VEGA Gene Model | MGI Sequence Detail 150386 C57BL/6J ±  kb
transcript OTTMUST00000005207 VEGA | MGI Sequence Detail 2889 Not Applicable 
polypeptide OTTMUSP00000067232 VEGA | MGI Sequence Detail 837 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(8) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(961 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR001762 Blood coagulation inhibitor, Disintegrin
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
Protein Ontology PR:000003719 disintegrin and metalloproteinase domain-containing protein 23
References
(Earliest) J:56924 Sagane K, et al., Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23. Gene. 1999 Aug 5;236(1):79-86
(Latest) J:208847 Kegel L, et al., Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination. Development. 2014 Apr;141(8):1749-56
All references(45)
Other
accession IDs
MGI:2138543

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory