Adam23
Gene Detail

Symbol

Name
ID

Adam23
a disintegrin and metallopeptidase domain 23
MGI:1345162

Synonyms

MDC3

Feature Type

protein coding gene

Genetic Map

Chromosome 1
32.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:63445891-63596276 bp, + strand From VEGA annotation of GRCm38   150386 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:2826  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Adam23

Human
homologs

Human Homolog		ADAM23, ADAM metallopeptidase domain 23
NCBI Gene ID		8745
neXtProt AC		NX_O75077
Human Synonyms		MDC3, MDC-3
Human Chr (Location)		2q33; chr2:206443544-206621130 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(17) : Gene trapped(14) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for an insertional mutation that inactivates the gene are smaller than normal littermates, show delayed lung development, are lethal by postnatal day 14, and display severe tremor and ataxia.

 

Interactions

Adam23 interacts with 428 markers (Mir1b, Mir7-1, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (11 annotations)

Process	cell adhesion, proteolysis
Component	extracellular region, integral component of membrane, ...
Function	metalloendopeptidase activity, metallopeptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)

Data Summary: Results (177)    Tissues (35)    Images (23)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	128
RT-PCR	49

cDNA source data(32)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(40) Genomic(1) cDNA(34) Primer pair(4) Other(1)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000002497 (Evidence)
Ensembl Gene Model	ENSMUSG00000025964 (Evidence)
Entrez Gene	23792 (Evidence)
UniGene	124892
DFCI	TC1584131, TC1675751, TC1621882, TC1646741, TC1622598, TC1585418, TC1589694, TC1752685, TC1619244
DoTS	DT.101172188, DT.482874, DT.102544546, DT.101731756, DT.522764, DT.94135627, DT.94337151, DT.91589794, DT.91387678
NIA Mouse Gene Index	U000370
Consensus CDS Project	CCDS14999.1, CCDS48279.1
International Mouse Knockout Project Status	Adam23

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002497	VEGA Gene Model | MGI Sequence Detail	150386	C57BL/6J
transcript	OTTMUST00000005207	VEGA | MGI Sequence Detail	2889	Not Applicable
polypeptide	OTTMUSP00000067232	VEGA | MGI Sequence Detail	837	Not Applicable

All sequences(87) RefSeq(10) UniProt(7)

Polymorphisms

PCR(1) : SNPs within 2kb(961 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR006586	ADAM, cysteine-rich
InterPro	IPR001762	Blood coagulation inhibitor, Disintegrin
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR001590	Peptidase M12B, ADAM/reprolysin
InterPro	IPR002870	Peptidase M12B, propeptide
Protein Ontology	PR:000003719	disintegrin and metalloproteinase domain-containing protein 23

References

(Earliest) J:56924 Sagane K, et al., Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23. Gene. 1999 Aug 5;236(1):79-86
(Latest) J:208847 Kegel L, et al., Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination. Development. 2014 Apr;141(8):1749-56
All references(45)

Other
accession IDs

MGI:2138543