Adam23 MGI Mouse Gene Detail - MGI:1345162 - a disintegrin and metallopeptidase domain 23

Adam23 Gene Detail

Symbol

Adam23
Name

a disintegrin and metallopeptidase domain 23
Synonyms

MDC3

Feature Type

protein coding gene
IDs

MGI:1345162
NCBI Gene: 23792
Gene Overview

MyGene.info: ADAM23
Alliance

gene page

Sequence Map

Chr1:63445891-63596276 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

150386 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 32.31 cM
Mapping Data

4 experiments

Human Ortholog

ADAM23, ADAM metallopeptidase domain 23

Vertebrate Orthologs

10

Human Ortholog

ADAM23, ADAM metallopeptidase domain 23
Orthology source: HomoloGene, HGNC
Synonyms

MDC3, MDC-3
Links

HGNC:202

NCBI Gene ID: 8745

neXtProt AC: NX_O75077

UniProt: O75077
Chr Location

2q33.3; chr2:206443544-206621130 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2826
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ADAM23
Gene Tree

Adam23

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Gene trapped

14
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Adam23
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available

Mice homozygous for an insertional mutation that inactivates the gene are smaller than normal littermates, show delayed lung development, are lethal by postnatal day 14, and display severe tremor and ataxia.

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All GO Annotations

11
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

298
Tissues

92
cDNA Data

32
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ADAM23

Xenbase adam23

ZFIN adam23a

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Adam23 interacts with 427 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

58
RefSeq

6
UniProt

2
CCDS

CCDS14999.1, CCDS48279.1
UniGene

124892

			Length	Strain/Species	Flank
genomic	OTTMUSG00000002497	VEGA Gene Model \| MGI Sequence Detail	150386	C57BL/6J	± kb
transcript	OTTMUST00000005207	VEGA \| MGI Sequence Detail	2889	Not Applicable
polypeptide	OTTMUSP00000067232	VEGA \| MGI Sequence Detail	837	Not Applicable

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SNPs within 2kb

952 from dbSNP Build 142

PCR

1

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UniProt

2 Sequences
InterPro Domains

IPR006586 ADAM, cysteine-rich

IPR001762 Disintegrin domain

IPR036436 Disintegrin domain superfamily

IPR013032 EGF-like, conserved site

IPR000742 EGF-like domain

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR001590 Peptidase M12B, ADAM/reprolysin

IPR002870 Peptidase M12B, propeptide

IPR034027 Reprolysin domain, adamalysin-type

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All nucleic 41

Genomic 1

cDNA 34

Primer pair 5

Other 1

Microarray probesets 5

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MGI:2138543

Summaries

All 51

Developmental Gene Expression 10

Gene Ontology 5

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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