Adam23 MGI Mouse Gene Detail - MGI:1345162 - a disintegrin and metallopeptidase domain 23

Symbol

Adam23
Name

a disintegrin and metallopeptidase domain 23
Synonyms

MDC3

Feature Type

protein coding gene
IDs

MGI:1345162
NCBI Gene: 23792
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:63484880-63635263 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 32.31 cM
Mapping Data

4 experiments

SNPs within 2kb

951 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345162	protein coding gene	Chr1:63484880-63635435 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016089	protein coding gene	Chr1:63610408-63760339 (+)
A/J	MGP_AJ_G0016072	protein coding gene	Chr1:61360331-61512527 (+)
AKR/J	MGP_AKRJ_G0016029	protein coding gene	Chr1:63060397-63216478 (+)
BALB/cJ	MGP_BALBcJ_G0016027	protein coding gene	Chr1:61438887-61592362 (+)
C3H/HeJ	MGP_C3HHeJ_G0015859	protein coding gene	Chr1:63349402-63507808 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016480	protein coding gene	Chr1:66058416-66224595 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014201	protein coding gene	Chr1:57457265-57607801 (+)
CAST/EiJ	MGP_CASTEiJ_G0015442	protein coding gene	Chr1:62603971-62781116 (+)
CBA/J	MGP_CBAJ_G0015831	protein coding gene	Chr1:68192272-68370014 (+)
DBA/2J	MGP_DBA2J_G0015932	protein coding gene	Chr1:60779277-60932127 (+)
FVB/NJ	MGP_FVBNJ_G0015935	protein coding gene	Chr1:60064370-60216028 (+)
LP/J	MGP_LPJ_G0016004	protein coding gene	Chr1:64496583-64655621 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015955	protein coding gene	Chr1:71115558-71296368 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016527	protein coding gene	Chr1:63038615-63216606 (+)
PWK/PhJ	MGP_PWKPhJ_G0015229	protein coding gene	Chr1:60146659-60305926 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015008	protein coding gene	Chr1:62546112-62712217 (+)
WSB/EiJ	MGP_WSBEiJ_G0015504	protein coding gene	Chr1:62763979-62925811 (+)

Human Ortholog

ADAM23, ADAM metallopeptidase domain 23

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADAM23, ADAM metallopeptidase domain 23
Synonyms

MDC3, MDC-3
Links

HGNC:202

NCBI Gene ID: 8745

neXtProt AC: NX_O75077

UniProt: O75077
Chr Location

2q33.3; chr2:206443544-206621130 (+) GRCh38.p7

Alliance of Genome Resources

Adam23 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADAM23
Gene Tree

Adam23

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

13
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Adam23
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an insertional mutation that inactivates the gene are smaller than normal littermates, show delayed lung development, are lethal by postnatal day 14, and display severe tremor and ataxia.

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1004
Tissues

92
cDNA Data

34
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ADAM23

Xenbase adam23

ZFIN adam23a

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Adam23 interacts with 427 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

59
RefSeq

6
UniProt

2
CCDS

CCDS14999.1, CCDS48279.1

Ensembl

ENSMUSG00000025964 (Evidence)
NCBI Gene

23792

			Length	Strain/Species	Flank
genomic	23792	NCBI Gene Model \| MGI Sequence Detail	150384	C57BL/6J	± kb
transcript	NM_011780	RefSeq \| MGI Sequence Detail	6271	C57BL/6
polypeptide	Q9R1V7	UniProt \| EBI \| MGI Sequence Detail	829	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003719 disintegrin and metalloproteinase domain-containing protein 23

(term hierarchy)
InterPro Domains

IPR006586 ADAM, cysteine-rich domain

IPR001762 Disintegrin domain

IPR036436 Disintegrin domain superfamily

IPR000742 EGF-like domain

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR001590 Peptidase M12B, ADAM/reprolysin

IPR002870 Peptidase M12B, propeptide

IPR034027 Reprolysin domain, adamalysin-type

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All nucleic 43

Genomic 1

cDNA 36

Primer pair 5

Other 1

Microarray probesets 5

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MGI:2138543

Summaries

All 56

Developmental Gene Expression 10

Gene Ontology 8

Phenotypes 17
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:319217 Elizondo DM, et al., Dendritic cell expression of ADAM23 governs T cell proliferation and cytokine production through the alpha(v)beta(3) integrin receptor. J Leukoc Biol. 2016 Nov;100(5):855-864

TSS for Adam23:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7068	Chr1:63484874-63484924 (+)	19 bp
Tssr7069	Chr1:63485001-63485102 (+)	172 bp
Tssr7070	Chr1:63485107-63485139 (+)	243 bp
Tssr7071	Chr1:63485165-63485179 (+)	292 bp
Tssr7072	Chr1:63485244-63485249 (+)	367 bp
Tssr7073	Chr1:63485334-63485344 (+)	459 bp
Tssr7074	Chr1:63567918-63567927 (+)	83,043 bp
Tssr7075	Chr1:63634974-63634979 (+)	150,097 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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