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Clec5a Gene Detail
Summary
  • Symbol
    Clec5a
  • Name
    C-type lectin domain family 5, member a
  • Synonyms
    Clecsf5, Ly100, MDL-1, myeloid DAP12-associating lectin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345151
    NCBI Gene: 23845
  • Gene Overview
    MyGene.info: CLEC5A
Location & Maps
more
  • Sequence Map
    Chr6:40574894-40585821 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10928 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 18.82 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CLEC5A, C-type lectin domain family 5 member A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CLEC5A, C-type lectin domain family 5 member A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CLECSF5, MDL1, MDL-1
  • Links
    NCBI Gene ID: 23601
    neXtProt AC: NX_Q9NY25

  • Chr Location
    7q33; chr7:141927357-141947007 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    1
  • Targeted
    1
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele exhibit decreased susceptibility to induced arthritis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026898 VEGA Gene Model | MGI Sequence Detail 10928 C57BL/6J ±  kb
transcript OTTMUST00000066519 VEGA | MGI Sequence Detail 858 Not Applicable  
polypeptide OTTMUSP00000033344 VEGA | MGI Sequence Detail 190 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    58 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:57105 Bakker AB, et al., Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9792-6
  • Latest
    J:204177 Inoue D, et al., Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations. J Clin Invest. 2013 Oct 8;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory