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Cdc6 Gene Detail
Summary
  • Symbol
    Cdc6
  • Name
    cell division cycle 6
  • Synonyms
    CDC18L, CDC18(S.pombe), cell division cycle 18 homolog (S.pombe)-like
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345150
    NCBI Gene: 23834
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98798627-98814766 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 62.74 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    573 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345150
 protein coding gene Chr11:98798627-98814768 (+)
129S1/SvImJ ENSMUSG00200051616
 protein coding gene Chr11:96060129-96076275 (+)
A/J ENSMUSG00195047082
 protein coding gene Chr11:95768882-95785021 (+)
AKR/J ENSMUSG00220050528
 protein coding gene Chr11:96027271-96043428 (+)
BALB/cJ ENSMUSG00180051160
 protein coding gene Chr11:96040605-96056744 (+)
C3H/HeJ ENSMUSG00175046780
 protein coding gene Chr11:96033699-96049841 (+)
C57BL/6NJ ENSMUSG00215051511
 protein coding gene Chr11:95616929-95633068 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017102
 protein coding gene Chr11:94825006-94840922 (+)
CAST/EiJ ENSTCUG00005048000
 protein coding gene Chr11:95546861-95563038 (+)
CBA/J ENSMUSG00210051502
 protein coding gene Chr11:95730843-95746982 (+)
DBA/2J ENSMUSG00185049081
 protein coding gene Chr11:96083608-96099750 (+)
FVB/NJ ENSMUSG00205038931
 protein coding gene Chr11:95950540-95966686 (+)
JF1/MsJ ENSUMUG00000044847
 protein coding gene Chr11:96378106-96394433 (+)
LP/J ENSMUSG00230044285
 protein coding gene Chr11:97136484-97152630 (+)
NOD/ShiLtJ ENSMUSG00190049531
 protein coding gene Chr11:96118565-96134707 (+)
NZO/HlLtJ ENSMUSG00225051363
 protein coding gene Chr11:99184922-99201061 (+)
PWK/PhJ ENSLUMG00010041998
 protein coding gene Chr11:95928937-95945259 (+)
SPRET/EiJ ENSMSPG00010045166
 protein coding gene Chr11:96457282-96470791 (+)
WSB/EiJ ENSIUOG00005049238
 protein coding gene Chr11:95887559-95903704 (+)



Homology
more
  • Human Ortholog
    CDC6, cell division cycle 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDC6, cell division cycle 6
  • Synonyms
    CDC18L, HsCDC18, HsCDC6, MGORS5
  • Links
    NCBI Gene ID: 990
    UniProt: Q99741

  • Chr Location
    17q21.2; chr17:40287831-40304657 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CDC6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    689
  • Tissues
    47
  • cDNA Data
    89
  • Literature Summary
    14
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017499 Ensembl Gene Model | MGI Sequence Detail 16140 C57BL/6J ±  kb
transcript ENSMUST00000093937 Ensembl | MGI Sequence Detail 2559 Not Applicable  
polypeptide ENSMUSP00000091469 Ensembl | MGI Sequence Detail 589 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 94
    Genomic 1
    cDNA 89
    Primer pair 4
    Antibodies 4

    Microarray probesets 3
References
more
  • Summaries
    All 71
    Developmental Gene Expression 14
    Gene Ontology 9
    Phenotypes 16
  • Earliest
    J:54767 Hateboer G, et al., Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. Mol Cell Biol. 1998 Nov;18(11):6679-97
  • Latest
    J:378546 Cui J, et al., Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance. Mol Cancer. 2024 Apr 29;23(1):86
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory