Cdc6
Gene Detail

Symbol Name ID

Cdc6 cell division cycle 6 MGI:1345150

Synonyms

CDC18L, CDC18(S.pombe), cell division cycle 18 homolog (S.pombe)-like

Feature Type

protein coding gene

Genetic Map

Chromosome 11

62.74 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:98907801-98923940 bp, + strand From VEGA annotation of GRCm38   16140 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68172  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: cell division control protein Cdc6
Gene Tree: Cdc6

Human homologs

Human Homolog		CDC6, cell division cycle 6
NCBI Gene ID		990
neXtProt AC		NX_Q99741
Human Synonyms		CDC18L, HsCDC18, HsCDC6
Human Chr (Location)		17q21.3; chr17:38444146-38459413 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CDC6

Alleles and phenotypes

All alleles(23) : Targeted(2) Gene trapped(21)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	cell cycle, cell division, ...
Component	cytoplasm, nucleus, ...
Function	ATP binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (40)    Tissues (27)    Images (13)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	40

cDNA source data(88)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(89) Genomic(1) cDNA(88)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006454 (Evidence)
Ensembl Gene Model	ENSMUSG00000017499 (Evidence)
Entrez Gene	23834 (Evidence)
UniGene	20912
DFCI	TC1576295, TC1657584
DoTS	DT.101387434, DT.110521295, DT.110521302, DT.484931, DT.530267
NIA Mouse Gene Index	U013318
Consensus CDS Project	CCDS25367.1, CCDS25368.1
International Mouse Knockout Project Status	Cdc6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006454	VEGA Gene Model | MGI Sequence Detail	16140	C57BL/6J
transcript	OTTMUST00000014747	VEGA | MGI Sequence Detail	2559	Not Applicable
polypeptide	OTTMUSP00000006853	VEGA | MGI Sequence Detail	589	Not Applicable

All sequences(43) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(94 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR015163	CDC6, C-terminal domain
InterPro	IPR016314	Cell division protein Cdc6/18
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000005217	cell division control protein 6

References

(Earliest) J:54767 Hateboer G, et al., Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. Mol Cell Biol. 1998 Nov;18(11):6679-97
(Latest) J:187480 Westendorp B, et al., The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy. FASEB J. 2012 Jun;26(6):2569-79
All references(43)