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Cdc6
Gene Detail
Symbol

Name
ID
Cdc6
cell division cycle 6
MGI:1345150
Synonyms
CDC18L, CDC18(S.pombe), cell division cycle 18 homolog (S.pombe)-like
Feature Type
protein coding gene
Genetic Map
Chromosome 11
62.74 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:98907801-98923942 bp, + strand
From VEGA annotation of GRCm38

  16142 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68172  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDC6
Protein SuperFamily: cell division control protein Cdc6
Gene Tree: Cdc6

Human
homologs
CDC6, cell division cycle 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 990
neXtProt AC: NX_Q99741

Human Synonyms: CDC18L, HsCDC18, HsCDC6

Human Chr (Location): 17q21.3; chr17:40287689-40303161 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CDC6

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(21) Targeted(3)
Genomic Mutations involving Cdc6 (1)
Incidental mutations (data from APF )
Interactions
Cdc6 interacts with 356 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, Golgi apparatus, ...
Function ATP binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (40)    Tissues (27)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 40
cDNA source data(88)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cdc6 ; ZFIN cdc6    NEW 
Molecular
reagents
All nucleic(89) Genomic(1) cDNA(88)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006454 (Evidence)
Ensembl Gene Model ENSMUSG00000017499 (Evidence)
Entrez Gene 23834 (Evidence)
UniGene 20912
DFCI TC1576295, TC1657584
DoTS DT.110521295, DT.101387434, DT.110521302, DT.484931, DT.530267
NIA Mouse Gene Index U013318
Consensus CDS Project CCDS25367.1, CCDS25368.1
International Mouse Phenotyping Consortium Status Cdc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006454 VEGA Gene Model | MGI Sequence Detail 16142 C57BL/6J ±  kb
transcript OTTMUST00000014747 VEGA | MGI Sequence Detail 2559 Not Applicable 
polypeptide OTTMUSP00000006853 VEGA | MGI Sequence Detail 589 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(7) UniProt(2)
Polymorphisms
SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR015163 CDC6, C-terminal domain
InterPro IPR016314 Cell division protein Cdc6/18
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000005217 cell division control protein 6
References
(Earliest) J:54767 Hateboer G, et al., Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. Mol Cell Biol. 1998 Nov;18(11):6679-97
(Latest) J:197897 Mi D, et al., Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb. Neuron. 2013 Apr 24;78(2):269-84
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory