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Cdc6
Gene Detail
Symbol

Name
ID
Cdc6
cell division cycle 6
MGI:1345150
Synonyms
CDC18L, CDC18(S.pombe), cell division cycle 18 homolog (S.pombe)-like
Feature Type
protein coding gene
Genetic Map
Chromosome 11
62.74 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:98907801-98923940 bp, + strand
From VEGA annotation of GRCm38

  16140 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68172  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cell division control protein Cdc6
Gene Tree: Cdc6

Human
homologs
Human Homolog CDC6, cell division cycle 6
NCBI Gene ID 990
neXtProt AC  NX_Q99741
Human Synonyms  CDC18L, HsCDC18, HsCDC6
Human Chr (Location)  17q21.3; chr17:40287894-40303161 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CDC6
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(21) Targeted(2)
Incidental mutations (data from APF )
Interactions
Cdc6 interacts with 357 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, Golgi apparatus, ...
Function ATP binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (40)    Tissues (27)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 40
cDNA source data(88)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(89) Genomic(1) cDNA(88)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006454 (Evidence)
Ensembl Gene ModelENSMUSG00000017499 (Evidence)
Entrez Gene23834 (Evidence)
UniGene20912
DFCITC1657584, TC1576295
DoTSDT.110521302, DT.530267, DT.484931, DT.110521295, DT.101387434
NIA Mouse Gene IndexU013318
Consensus CDS ProjectCCDS25367.1, CCDS25368.1
International Mouse Knockout Project StatusCdc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006454 VEGA Gene Model | MGI Sequence Detail 16140 C57BL/6J ±  kb
transcript OTTMUST00000014747 VEGA | MGI Sequence Detail 2559 Not Applicable 
polypeptide OTTMUSP00000006853 VEGA | MGI Sequence Detail 589 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(7) UniProt(3)
Polymorphisms
SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR015163 CDC6, C-terminal domain
InterPro IPR016314 Cell division protein Cdc6/18
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000005217 cell division control protein 6
References
(Earliest) J:54767 Hateboer G, et al., Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. Mol Cell Biol. 1998 Nov;18(11):6679-97
(Latest) J:197897 Mi D, et al., Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb. Neuron. 2013 Apr 24;78(2):269-84
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory