About   Help   FAQ
Scn11a Gene Detail
Summary
  • Symbol
    Scn11a
  • Name
    sodium channel, voltage-gated, type XI, alpha
  • Synonyms
    NaN, NaT, NSS2, SNS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345149
    NCBI Gene: 24046
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr9:119582829-119654522 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 71.33 cM, cytoband F3-F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    772 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345149
protein coding gene Chr9:119582825-119654522 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035423
protein coding gene Chr9:122552020-122628895 (-)
A/J MGP_AJ_G0035404
protein coding gene Chr9:117980047-118051722 (-)
AKR/J MGP_AKRJ_G0035337
protein coding gene Chr9:121059623-121140104 (-)
BALB/cJ MGP_BALBcJ_G0035400
protein coding gene Chr9:117859191-117940074 (-)
C3H/HeJ MGP_C3HHeJ_G0035108
protein coding gene Chr9:121525581-121603751 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035923
protein coding gene Chr9:125902401-125980869 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032805
protein coding gene Chr9:115180593-115253379 (-)
CAST/EiJ MGP_CASTEiJ_G0034412
protein coding gene Chr9:121534058-121615254 (-)
CBA/J MGP_CBAJ_G0035075
protein coding gene Chr9:130621975-130701117 (-)
DBA/2J MGP_DBA2J_G0035234
protein coding gene Chr9:117421047-117493871 (-)
FVB/NJ MGP_FVBNJ_G0035181
protein coding gene Chr9:116293609-116366710 (-)
LP/J MGP_LPJ_G0035313
protein coding gene Chr9:122893668-122971425 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035222
protein coding gene Chr9:131568532-131650197 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035942
protein coding gene Chr9:121446432-121521447 (-)
PWK/PhJ MGP_PWKPhJ_G0034117
protein coding gene Chr9:117860695-117935380 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033953
protein coding gene Chr9:121545525-121619689 (-)
WSB/EiJ MGP_WSBEiJ_G0034532
protein coding gene Chr9:121336644-121418013 (-)



Homology
more
  • Human Ortholog
    SCN11A, sodium voltage-gated channel alpha subunit 11
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCN11A, sodium voltage-gated channel alpha subunit 11
  • Synonyms
    FEPS3, HSAN7, NaN, NAV1.9, PN5, SCN12A, SNS-2
  • Links
    NCBI Gene ID: 11280
    neXtProt AC: NX_Q9UI33
    UniProt: Q9UI33

  • Chr Location
    3p22.2; chr3:38845764-39052157 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with Scn11a mouse models; 2 with human SCN11A associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 10 alleles in 8 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous and heterozygous for one null allele display decreased duration of inflammation induced thermal hyperalgesia and decreased late phase pain responses to inflammatory stimuli. Mice homozygous for a second allele appear normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24046 NCBI Gene Model | MGI Sequence Detail 71694 C57BL/6J ±  kb
    transcript NM_011887 RefSeq | MGI Sequence Detail 5837 Not Specified  
    polypeptide Q9R053 UniProt | EBI | MGI Sequence Detail 1765 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000002097 sodium channel protein type 11 subunit alpha
    • InterPro Domains
      IPR005821 Ion transport domain
      IPR010526 Sodium ion transport-associated domain
      IPR027359 Voltage-dependent channel domain superfamily
      IPR043203 Voltage-gated cation channel calcium and sodium
      IPR001696 Voltage gated sodium channel, alpha subunit
      IPR044564 Voltage-gated sodium channel alpha subunit, inactivation gate
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 8
      Primer pair 6
      Other 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 15
      Diseases 2
      Gene Ontology 25
      Phenotypes 33
    • Earliest
      J:57019 Dib-Hajj SD, et al., Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN. Genomics. 1999 Aug 1;59(3):309-18
    • Latest
      J:340650 Jami S, et al., Pain-causing stinging nettle toxins target TMEM233 to modulate Na(V)1.7 function. Nat Commun. 2023 Apr 28;14(1):2442

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory