Scn11a
Gene Detail

Symbol Name ID

Scn11a sodium channel, voltage-gated, type XI, alpha MGI:1345149

Synonyms

NaN, NaT, NSS2, SNS2

Feature Type

protein coding gene

Genetic Map

Chromosome 9

71.33 cM, cytoband F3-F4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:119753763-119825456 bp, - strand From NCBI annotation of GRCm38   71694 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8041  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: voltage-gated sodium channel
Gene Tree: Scn11a

Human homologs

Human Homolog		SCN11A, sodium channel, voltage-gated, type XI, alpha subunit
NCBI Gene ID		11280
neXtProt AC		NX_Q9UI33
Human Synonyms		NaN, NAV1.9, SCN12A, SNS-2
Human Chr (Location)		3p22.2; chr3:38887260-38992052 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous and heterozygous for one null allele display decreased duration of inflammation induced thermal hyperalgesia and decreased late phase pain responses to inflammatory stimuli. Mice homozygous for a second allele appear normal.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	ion transmembrane transport, ion transport, ...
Component	axon, C-fiber, ...
Function	ion channel activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (153)    Tissues (65)    Images (17)
Theiler Stages: 10, 17, 18, 23, 25, 28

Assay Type	Results
RNA in situ	28
In situ reporter (knock in)	51
Northern blot	16
RT-PCR	58

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(9) Primer pair(4)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000034115 (Evidence)
Entrez Gene	24046 (Evidence)
UniGene	89981
DFCI	TC1591703
DoTS	DT.101244965, DT.91443985
NIA Mouse Gene Index	U031432
Consensus CDS Project	CCDS40804.1
International Mouse Knockout Project Status	Scn11a

Sequences

Length	Strain/Species
genomic	24046	NCBI Gene Model | MGI Sequence Detail	71694	C57BL/6J
transcript	NM_011887	RefSeq | MGI Sequence Detail	5837	Not Specified
polypeptide	Q9R053	UniProt | EBI | MGI Sequence Detail	1765	Not Applicable

All sequences(22) RefSeq(2) UniProt(1)

Polymorphisms

PCR(1) : SNPs(323 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005821	Ion transport domain
InterPro	IPR010526	Sodium ion transport-associated
InterPro	IPR027359	Voltage-dependent potassium channel, four helix bundle domain
InterPro	IPR001696	Voltage gated sodium channel, alpha subunit
Protein Ontology	PR:000002097	sodium channel type 11 subunit alpha

Graphical View of Protein Domain Structure

References

(Earliest) J:57019 Dib-Hajj SD, et al., Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN. Genomics. 1999 Aug 1;59(3):309-18
(Latest) J:186617 Hao MM, et al., Early development of electrical excitability in the mouse enteric nervous system. J Neurosci. 2012 Aug 8;32(32):10949-60
All references(44)