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Scn11a
Gene Detail
Symbol

Name
ID
Scn11a
sodium channel, voltage-gated, type XI, alpha
MGI:1345149
Synonyms
NaN, NaT, NSS2, SNS2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
71.33 cM, cytoband F3-F4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:119753763-119825456 bp, - strand
From Ensembl annotation of GRCm38

  71694 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8041  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SCN11A
Protein SuperFamily: voltage-gated sodium channel
Gene Tree: Scn11a

Human
homologs
SCN11A, sodium channel, voltage gated, type XI alpha subunit
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11280
neXtProt AC: NX_Q9UI33

Human Synonyms: FEPS3, HSAN7, NaN, NAV1.9, PN5, SCN12A, SNS-2

Human Chr (Location): 3p22.2; chr3:38845769-38953651 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SCN11A

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous and heterozygous for one null allele display decreased duration of inflammation induced thermal hyperalgesia and decreased late phase pain responses to inflammatory stimuli. Mice homozygous for a second allele appear normal.
 
Human Diseases Modeled in Mice Using Scn11a (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Scn11a interacts with 149 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process ion transport, membrane depolarization during action potential, ...
Component axon, C-fiber, ...
Function ion channel activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (153)    Tissues (66)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
In situ reporter (knock in) 51
Northern blot 16
RT-PCR 58
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(7) Primer pair(4)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000034115 (Evidence)
Entrez Gene 24046 (Evidence)
DFCI TC1591703
DoTS DT.91443985, DT.101244965
NIA Mouse Gene Index U031432, U378650
Consensus CDS Project CCDS40804.1
International Mouse Phenotyping Consortium Status Scn11a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034115 Ensembl Gene Model | MGI Sequence Detail 71694 C57BL/6J ±  kb
transcript ENSMUST00000070617 Ensembl | MGI Sequence Detail 5837 Not Applicable 
polypeptide ENSMUSP00000065466 Ensembl | MGI Sequence Detail 1765 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(6) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(779 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR010526 Sodium ion transport-associated
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
InterPro IPR001696 Voltage gated sodium channel, alpha subunit
Protein Ontology PR:000002097 sodium channel protein type 11 subunit alpha
References
(Earliest) J:57019 Dib-Hajj SD, et al., Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN. Genomics. 1999 Aug 1;59(3):309-18
(Latest) J:208794 Minett MS, et al., Pain without nociceptors? Nav1.7-independent pain mechanisms. Cell Rep. 2014 Jan 30;6(2):301-12
All references(50)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory