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Pde10a Gene Detail
Summary
  • Symbol
    Pde10a
  • Name
    phosphodiesterase 10A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345143
    NCBI Gene: 23984
  • Gene Overview
    MyGene.info: PDE10A
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:8525372-8986648 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 4.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3057 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345143
protein coding gene Chr17:8525185-8986648 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023136
protein coding gene Chr17:6004340-6486175 (+)
A/J MGP_AJ_G0023104
protein coding gene Chr17:6023107-6490100 (+)
AKR/J MGP_AKRJ_G0023068
protein coding gene Chr17:5714589-6189492 (+)
BALB/cJ MGP_BALBcJ_G0023104
protein coding gene Chr17:5818988-6272278 (+)
C3H/HeJ MGP_C3HHeJ_G0022867
protein coding gene Chr17:5978681-6454807 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023547
protein coding gene Chr17:6293023-6785151 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021060
protein coding gene Chr17:7899206-8345966 (-)
CAST/EiJ MGP_CASTEiJ_G0022381
protein coding gene Chr17:5958670-6458366 (+)
CBA/J MGP_CBAJ_G0022839
protein coding gene Chr17:6508787-7037603 (+)
DBA/2J MGP_DBA2J_G0022972
protein coding gene Chr17:5687664-6146999 (+)
FVB/NJ MGP_FVBNJ_G0022941
protein coding gene Chr17:5616700-6076418 (+)
LP/J MGP_LPJ_G0023043
protein coding gene Chr17:5830152-6314579 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022961
protein coding gene Chr17:6239274-6735128 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023573
protein coding gene Chr17:5996595-6484357 (+)
PWK/PhJ MGP_PWKPhJ_G0022129
protein coding gene Chr17:5321661-5792823 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021959
protein coding gene Chr17:5263668-5738864 (+)
WSB/EiJ MGP_WSBEiJ_G0022438
protein coding gene Chr17:6297598-6779504 (+)



Homology
more
  • Human Ortholog
    PDE10A, phosphodiesterase 10A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDE10A, phosphodiesterase 10A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADSD2, HSPDE10A, IOLOD, LINC00473, PDE10A19
  • Links
    NCBI Gene ID: 10846
    neXtProt AC: NX_Q9Y233
    UniProt: Q9Y233

  • Chr Location
    6q27; chr6:165327287-165988121 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 5 alleles in 5 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in decreased exploratory behavior, hypoactivity, and a delay in the acquisition of conditioned avoidance behavior. A hypomorphic allele results in increased social behavior. Mice homozygous for a knock-out allele exhibit resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023868 Ensembl Gene Model | MGI Sequence Detail 461277 C57BL/6J ±  kb
    transcript ENSMUST00000115724 Ensembl | MGI Sequence Detail 3611 Not Applicable  
    polypeptide ENSMUSP00000111389 Ensembl | MGI Sequence Detail 850 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 46

      Microarray probesets 7
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 23
    • Earliest
      J:7073 Washburn LL, et al., Sex reversal in XY mice caused by dominant mutation on chromosome 17. Nature. 1983 May 26;303(5915):338-40
    • Latest
      J:261166 Bouchekioua Y, et al., Striatonigral direct pathway activation is sufficient to induce repetitive behaviors. Neurosci Res. 2017 Sep 20;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory