About   Help   FAQ
Pde10a
Gene Detail
 Symbol
Name
ID
Pde10a
phosphodiesterase 10A
MGI:1345143
Feature Type protein coding gene
Genetic Map
Chromosome 17
4.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:8525372-8986648 bp, + strand
From VEGA annotation of GRCm38

  461277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4852  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 3',5'-cyclic-GMP phosphodiesterase alpha chain
Gene Tree: Pde10a

Human
homologs
Human Homolog PDE10A, phosphodiesterase 10A
NCBI Gene ID 10846
neXtProt AC  NX_Q9Y233
Human Synonyms  HSPDE10A
Human Chr (Location)  6q26; chr6:165327287-165662100 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in decreased exploratory behavior, hypoactivity, and a delay in the acquisition of conditioned avoidance behavior. A hypomorphic allele results in increased social behavior. Mice homozygous for a knock-out allele exhibit resistance to diet-induced obesity.
 
Interactions
Pde10a interacts with 470 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cAMP catabolic process, cGMP catabolic process, ...
Component cytoplasm, membrane, ...
Function 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (243)    Tissues (121)    Images (35)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 243
cDNA source data(44)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(45)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000021581 (Evidence)
Ensembl Gene ModelENSMUSG00000023868 (Evidence)
Entrez Gene23984 (Evidence)
UniGene87161
DFCITC1582513, TC1601979, TC1602731, TC1636162, TC1640772
DoTSDT.101371251, DT.101371252, DT.101735457, DT.110548287, DT.40143912, DT.40144112, DT.40166198, DT.55273658, DT.91581295, DT.94259699
NIA Mouse Gene IndexU017473
EC3.1.4.17, 3.1.4.35
Consensus CDS ProjectCCDS28384.1
International Mouse Knockout Project StatusPde10a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021581 VEGA Gene Model | MGI Sequence Detail 461277 C57BL/6J ±  kb
transcript OTTMUST00000051222 VEGA | MGI Sequence Detail 7717 Not Applicable 
polypeptide OTTMUSP00000024055 VEGA | MGI Sequence Detail 796 Not Applicable 

For the selected sequences
All sequences(103) RefSeq(22) UniProt(6)
Polymorphisms SNPs within 2kb(3076 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3078)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR003018 GAF domain
InterPro IPR003607 HD/PDEase domain
Protein Ontology PR:000012463 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
References (Earliest) J:55626 Soderling SH, et al., Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):7071-6
(Latest) J:209032 Nawrocki AR, et al., Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistance. Diabetes. 2014 Jan;63(1):300-11
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory