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Pde10a Gene Detail
Summary
  • Symbol
    Pde10a
  • Name
    phosphodiesterase 10A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345143
    NCBI Gene: 23984
  • Gene Overview
    MyGene.info: PDE10A
Location & Maps
more
  • Sequence Map
    Chr17:8525372-8986648 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      461277 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 4.96 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PDE10A, phosphodiesterase 10A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDE10A, phosphodiesterase 10A
    Orthology source: HomoloGene
  • Synonyms
    ADSD2, HSPDE10A, IOLOD, LINC00473, PDE10A19
  • Links
    NCBI Gene ID: 10846
    neXtProt AC: NX_Q9Y233

  • Chr Location
    6q26; chr6:165327287-165711153 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human PDE10A associations

Human Disease Mouse Models
       Dyskinesia, Limb and Orofacial, Infantile-Onset; IOLOD   OMIM: 616921
Striatal Degeneration, Autosomal Dominant 2; ADSD2   OMIM: 616922
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 4 alleles in 4 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Gene trapped
    1
  • Not Applicable
    1
  • Radiation induced
    7
  • Targeted
    8
  • Genomic Mutations
    8 involving Pde10a
  • Incidental Mutations
Homozygous mutation of this gene results in decreased exploratory behavior, hypoactivity, and a delay in the acquisition of conditioned avoidance behavior. A hypomorphic allele results in increased social behavior. Mice homozygous for a knock-out allele exhibit resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021581 VEGA Gene Model | MGI Sequence Detail 461277 C57BL/6J ±  kb
transcript OTTMUST00000051222 VEGA | MGI Sequence Detail 7717 Not Applicable  
polypeptide OTTMUSP00000024055 VEGA | MGI Sequence Detail 796 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3057 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 45
    cDNA 45

    Microarray probesets 7
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 20
  • Earliest
    J:55626 Soderling SH, et al., Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):7071-6
  • Latest
    J:222588 Russwurm C, et al., Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum. J Biol Chem. 2015 May 8;290(19):11936-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory