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Ik Gene Detail
Summary
  • Symbol
    Ik
  • Name
    IK cytokine
  • Synonyms
    MuRED
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345142
    NCBI Gene: 24010
  • Gene Overview
    MyGene.info: IK
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:36744656-36757639 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.46 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345142
protein coding gene Chr18:36744656-36757639 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024288
protein coding gene Chr18:35157664-35170690 (+)
A/J MGP_AJ_G0024254
protein coding gene Chr18:33918692-33931680 (+)
AKR/J MGP_AKRJ_G0024222
protein coding gene Chr18:34873739-34886729 (+)
BALB/cJ MGP_BALBcJ_G0024254
protein coding gene Chr18:33967826-33980823 (+)
C3H/HeJ MGP_C3HHeJ_G0024021
protein coding gene Chr18:34937672-34950651 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024695
protein coding gene Chr18:36393268-36407338 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022135
protein coding gene Chr18:34011126-34024883 (+)
CAST/EiJ MGP_CASTEiJ_G0023496
protein coding gene Chr18:34952500-34965507 (+)
CBA/J MGP_CBAJ_G0023989
protein coding gene Chr18:37471946-37484939 (+)
DBA/2J MGP_DBA2J_G0024121
protein coding gene Chr18:33535770-33548805 (+)
FVB/NJ MGP_FVBNJ_G0024088
protein coding gene Chr18:33245457-33258455 (+)
LP/J MGP_LPJ_G0024203
protein coding gene Chr18:35191929-35204903 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024116
protein coding gene Chr18:38685036-38699027 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024744
protein coding gene Chr18:34743413-34757123 (+)
PWK/PhJ MGP_PWKPhJ_G0023240
protein coding gene Chr18:33796638-33810013 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023047
protein coding gene Chr18:34996512-35009569 (+)
WSB/EiJ MGP_WSBEiJ_G0023559
protein coding gene Chr18:34663848-34676841 (+)



Homology
more
  • Human Ortholog
    IK, IK cytokine
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IK, IK cytokine
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSA2, RED, RER
  • Links
    NCBI Gene ID: 3550
    neXtProt AC: NX_Q13123
    UniProt: Q13123

  • Chr Location
    5q31.3; chr5:140647799-140662480 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 36193
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
  • HCOP
    human homology predictions: IK
  • Gene Tree
    Ik
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 24010 NCBI Gene Model | MGI Sequence Detail 12984 C57BL/6J ±  kb
transcript NM_011879 RefSeq | MGI Sequence Detail 1996 C57BL/6  
polypeptide Q9Z1M8 UniProt | EBI | MGI Sequence Detail 557 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 194
    cDNA 193
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:54439 Bouzinba-Segard H, et al., Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat. Gene. 1999 Apr 16;230(2):145-54
  • Latest
    J:213637 Lee S, et al., Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases. FEBS Lett. 2014 Aug 25;588(17):2844-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory