Aloxe3
Gene Detail

Symbol Name ID

Aloxe3 arachidonate lipoxygenase 3 MGI:1345140

Synonyms

e-LOX-3

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:69125896-69149115 bp, + strand From VEGA annotation of GRCm38   23220 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8013  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: arachidonate 5-lipoxygenase
Gene Tree: Aloxe3

Human homologs

Human Homolog		ALOXE3, arachidonate lipoxygenase 3
NCBI Gene ID		59344
neXtProt AC		NX_Q9BYJ1
Human Synonyms		ARCI3, E-LOX, eLOX3
Human Chr (Location)		17p13.1; chr17:7999218-8022234 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ALOXE3

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	leukotriene biosynthetic process, leukotriene metabolic process, ...
Function	catalytic activity, iron ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(9)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005966 (Evidence)
Ensembl Gene Model	ENSMUSG00000020892 (Evidence)
Entrez Gene	23801 (Evidence)
UniGene	41989
DFCI	TC1586687
DoTS	DT.40154281, DT.40177175
NIA Mouse Gene Index	U012812
EC	1.13.11.-
Consensus CDS Project	CCDS24884.1
International Mouse Knockout Project Status	Aloxe3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005966	VEGA Gene Model | MGI Sequence Detail	23220	C57BL/6J
transcript	OTTMUST00000013322	VEGA | MGI Sequence Detail	3019	Not Applicable
polypeptide	OTTMUSP00000006170	VEGA | MGI Sequence Detail	711	Not Applicable

All sequences(33) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(93 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008976	Lipase/lipooxygenase, PLAT/LH2
InterPro	IPR000907	Lipoxygenase
InterPro	IPR020834	Lipoxygenase, conserved site
InterPro	IPR013819	Lipoxygenase, C-terminal
InterPro	IPR020833	Lipoxygenase, iron binding site
InterPro	IPR001024	Lipoxygenase, LH2
InterPro	IPR001885	Lipoxygenase, mammalian
Protein Ontology	PR:000003963	epidermis-type lipoxygenase 3

References

(Earliest) J:51789 Kinzig A, et al., cDNA cloning, genomic structure, and chromosomal localization of a novel murine epidermis-type lipoxygenase. Genomics. 1999 Jun 1;58(2):158-64
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)