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Aloxe3
Gene Detail
 Symbol
Name
ID
Aloxe3
arachidonate lipoxygenase 3
MGI:1345140
Synonyms e-LOX-3
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:69125896-69149115 bp, + strand
From VEGA annotation of GRCm38

  23220 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8013  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 5 western clawed frog; 2 zebrafish

Protein SuperFamily: arachidonate 5-lipoxygenase
Gene Tree: Aloxe3

Human
homologs
Human Homolog ALOXE3, arachidonate lipoxygenase 3
NCBI Gene ID 59344
neXtProt AC  NX_Q9BYJ1
Human Synonyms  ARCI3, E-LOX, eLOX3, eLOX-3
Human Chr (Location)  17p13.1; chr17:8095900-8118916 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ALOXE3
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit complete neonatal lethality, imapired skin barrier function, dehydration, tightly packed stratum corneum, impaired stratum corneum desquamation and reduced levels of ester-bound ceramide in the epidermis.
 
Interactions
Aloxe3 interacts with 82 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (78 annotations)
Process arachidonic acid metabolic process, ceramide biosynthetic process, ...
Component cytoplasm
Function 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity, 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005966 (Evidence)
Ensembl Gene ModelENSMUSG00000020892 (Evidence)
Entrez Gene23801 (Evidence)
UniGene41989
DFCITC1586687
DoTSDT.40154281, DT.40177175
NIA Mouse Gene IndexU012812
EC1.13.11.-, 5.4.4.-
Consensus CDS ProjectCCDS24884.1
International Mouse Knockout Project StatusAloxe3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005966 VEGA Gene Model | MGI Sequence Detail 23220 C57BL/6J ±  kb
transcript OTTMUST00000013322 VEGA | MGI Sequence Detail 3019 Not Applicable 
polypeptide OTTMUSP00000006170 VEGA | MGI Sequence Detail 711 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(221 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008976 Lipase/lipooxygenase, PLAT/LH2
InterPro IPR000907 Lipoxygenase
InterPro IPR020834 Lipoxygenase, conserved site
InterPro IPR013819 Lipoxygenase, C-terminal
InterPro IPR020833 Lipoxygenase, iron binding site
InterPro IPR001024 Lipoxygenase, LH2
InterPro IPR001885 Lipoxygenase, mammalian
Protein Ontology PR:000003963 epidermis-type lipoxygenase 3
References (Earliest) J:51789 Kinzig A, et al., cDNA cloning, genomic structure, and chromosomal localization of a novel murine epidermis-type lipoxygenase. Genomics. 1999 Jun 1;58(2):158-64
(Latest) J:196489 Krieg P, et al., Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation. J Invest Dermatol. 2013 Jan;133(1):172-80
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory