About   Help   FAQ
Aloxe3 Gene Detail
Summary
  • Symbol
    Aloxe3
  • Name
    arachidonate lipoxygenase 3
  • Synonyms
    e-LOX-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345140
    NCBI Gene: 23801
  • Gene Overview
    MyGene.info: ALOXE3
Location & Maps
more
  • Sequence Map
    Chr11:69125896-69149115 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23220 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.38 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ALOXE3, arachidonate lipoxygenase 3
  • Vertebrate Orthologs
    14
  • Human Ortholog
    ALOXE3, arachidonate lipoxygenase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARCI3, E-LOX, eLOX3, eLOX-3
  • Links
    NCBI Gene ID: 59344
    neXtProt AC: NX_Q9BYJ1

  • Chr Location
    17p13.1; chr17:8095900-8118916 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human ALOXE3 associations

Human Disease Mouse Models
       Ichthyosis, Congenital, Autosomal Recessive 2; ARCI2   OMIM: 242100
Ichthyosis, Congenital, Autosomal Recessive 3; ARCI3   OMIM: 606545
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Aloxe3
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit complete neonatal lethality, imapired skin barrier function, dehydration, tightly packed stratum corneum, impaired stratum corneum desquamation and reduced levels of ester-bound ceramide in the epidermis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005966 VEGA Gene Model | MGI Sequence Detail 23220 C57BL/6J ±  kb
transcript OTTMUST00000013322 VEGA | MGI Sequence Detail 3019 Not Applicable  
polypeptide OTTMUSP00000006170 VEGA | MGI Sequence Detail 711 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    220 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:51789 Kinzig A, et al., cDNA cloning, genomic structure, and chromosomal localization of a novel murine epidermis-type lipoxygenase. Genomics. 1999 Jun 1;58(2):158-64
  • Latest
    J:196489 Krieg P, et al., Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation. J Invest Dermatol. 2013 Jan;133(1):172-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory