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Aloxe3 Gene Detail
Summary
  • Symbol
    Aloxe3
  • Name
    arachidonate lipoxygenase 3
  • Synonyms
    e-LOX-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345140
    NCBI Gene: 23801
  • Gene Overview
    MyGene.info: ALOXE3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69125896-69149115 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.38 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    220 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345140
protein coding gene Chr11:69125525-69149115 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018521
protein coding gene Chr11:69531184-69554480 (+)
A/J MGP_AJ_G0018490
protein coding gene Chr11:66917304-66941122 (+)
AKR/J MGP_AKRJ_G0018459
protein coding gene Chr11:68920807-68944024 (+)
BALB/cJ MGP_BALBcJ_G0018461
protein coding gene Chr11:67238877-67262256 (+)
C3H/HeJ MGP_C3HHeJ_G0018274
protein coding gene Chr11:68937452-68962266 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018913
protein coding gene Chr11:71644982-71669261 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016557
protein coding gene Chr11:63856780-63880787 (+)
CAST/EiJ MGP_CASTEiJ_G0017830
protein coding gene Chr11:69174734-69199322 (+)
CBA/J MGP_CBAJ_G0018248
protein coding gene Chr11:74855733-74882386 (+)
DBA/2J MGP_DBA2J_G0018357
protein coding gene Chr11:66516035-66540252 (+)
FVB/NJ MGP_FVBNJ_G0018347
protein coding gene Chr11:66138065-66161968 (+)
LP/J MGP_LPJ_G0018428
protein coding gene Chr11:70118171-70141471 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018370
protein coding gene Chr11:75480156-75505682 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018954
protein coding gene Chr11:69166120-69191295 (+)
PWK/PhJ MGP_PWKPhJ_G0017605
protein coding gene Chr11:67153280-67177331 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017393
protein coding gene Chr11:68998933-69025078 (+)
WSB/EiJ MGP_WSBEiJ_G0017883
protein coding gene Chr11:68806895-68831349 (+)



Homology
more
  • Human Ortholog
    ALOXE3, arachidonate lipoxygenase 3
  • Vertebrate Orthologs
    14
  • Human Ortholog
    ALOXE3, arachidonate lipoxygenase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARCI3, E-LOX, eLOX3, eLOX-3
  • Links
    NCBI Gene ID: 59344
    neXtProt AC: NX_Q9BYJ1
    UniProt: Q9BYJ1

  • Chr Location
    17p13.1; chr17:8095900-8118916 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human ALOXE3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Aloxe3
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele exhibit complete neonatal lethality, imapired skin barrier function, dehydration, tightly packed stratum corneum, impaired stratum corneum desquamation and reduced levels of ester-bound ceramide in the epidermis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020892 Ensembl Gene Model | MGI Sequence Detail 23220 C57BL/6J ±  kb
transcript ENSMUST00000021268 Ensembl | MGI Sequence Detail 3019 Not Applicable  
polypeptide ENSMUSP00000021268 Ensembl | MGI Sequence Detail 711 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:242353 Pichery M, et al., PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier. Hum Mol Genet. 2017 May 15;26(10):1787-1800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory