About   Help   FAQ
Spry1
Gene Detail
 Symbol
Name
ID
Spry1
sprouty homolog 1 (Drosophila)
MGI:1345139
Synonyms sprouty1, sprouty 1
Feature Type protein coding gene
Genetic Map
Chromosome 3
18.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:37639947-37644598 bp, + strand
From VEGA annotation of GRCm38

  4652 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4266  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sprouty homolog protein
Gene Tree: Spry1

Human
homologs
Human Homolog SPRY1, sprouty homolog 1, antagonist of FGF signaling (Drosophila)
NCBI Gene ID 10252
neXtProt AC  NX_O43609
Human Synonyms  hSPRY1
Human Chr (Location)  4q28.1; chr4:123396791-123403760 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Homozygous null mice display postnatal lethality, premature death, abnormal kidney morphology and development with multiple ectopic ureteric buds, multiple ureters, and hydroureter.
 
Human Diseases Modeled Using Mouse Spry1 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process bud elongation involved in lung branching, establishment of mitotic spindle orientation, ...
Component cell, cytoplasm, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (92 records)
Data Summary: Results (83)    Tissues (70)    Images (32)
Theiler Stages: 11, 12, 15, 17, 19, 20, 21, 22, 24, 26, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 75
Northern blot 5
RT-PCR 2
cDNA source data(36)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(41) cDNA(37) Primer pair(1) Other(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000007497 (Evidence)
Ensembl Gene ModelENSMUSG00000037211 (Evidence)
Entrez Gene24063 (Evidence)
UniGene330986
DFCITC1578218, TC1590782, TC1632130
DoTSDT.101283565, DT.101379407, DT.101379415, DT.50315837
NIA Mouse Gene IndexU042423
Consensus CDS ProjectCCDS17322.1
International Mouse Knockout Project StatusSpry1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007497 VEGA Gene Model | MGI Sequence Detail 4652 C57BL/6J ±  kb
transcript OTTMUST00000017294 VEGA | MGI Sequence Detail 2773 Not Applicable 
polypeptide OTTMUSP00000007986 VEGA | MGI Sequence Detail 313 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007875 Sprouty
Protein Ontology PR:000015582 protein sprouty homolog 1
References (Earliest) J:55241 Minowada G, et al., Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development. 1999 Oct;126(20):4465-75
(Latest) J:206853 Cebrian C, et al., The Number of Fetal Nephron Progenitor Cells Limits Ureteric Branching and Adult Nephron Endowment. Cell Rep. 2014 Mar 19;
All references(141)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory