Spry1
Gene Detail

Symbol Name ID

Spry1 sprouty homolog 1 (Drosophila) MGI:1345139

Synonyms

sprouty1, sprouty 1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

18.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:37639947-37644598 bp, + strand From VEGA annotation of GRCm38   4652 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4266  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sprouty homolog protein
Gene Tree: Spry1

Human homologs

Human Homolog		SPRY1, sprouty homolog 1, antagonist of FGF signaling (Drosophila)
NCBI Gene ID		10252
neXtProt AC		NX_O43609
Human Synonyms		hSPRY1
Human Chr (Location)		4q28.1; chr4:124317950-124324915 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous null mice display postnatal lethality, premature death, abnormal kidney morphology and development with multiple ectopic ureteric buds, multiple ureters, and hydroureter.

 
Human Diseases Modeled Using Mouse Spry1 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	metanephros development, multicellular organismal development, ...
Component	cytoplasm, membrane
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (85 records)
Data Summary: Results (83)    Tissues (70)    Images (32)
Theiler Stages: 11, 12, 15, 17, 19, 20, 21, 22, 24, 26, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	75
Northern blot	5
RT-PCR	2

cDNA source data(35)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(40) cDNA(36) Primer pair(1) Other(3)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000007497 (Evidence)
Ensembl Gene Model	ENSMUSG00000037211 (Evidence)
Entrez Gene	24063 (Evidence)
UniGene	330986
DFCI	TC1578218, TC1590782, TC1632130
DoTS	DT.101283565, DT.101379407, DT.101379415, DT.50315837
NIA Mouse Gene Index	U042423
Consensus CDS Project	CCDS17322.1
International Mouse Knockout Project Status	Spry1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007497	VEGA Gene Model | MGI Sequence Detail	4652	C57BL/6J
transcript	OTTMUST00000017292	VEGA | MGI Sequence Detail	2481	Not Applicable
polypeptide	OTTMUSP00000007984	VEGA | MGI Sequence Detail	313	Not Applicable

All sequences(37) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(14 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007875	Sprouty
Protein Ontology	PR:000015582	protein sprouty 1

References

(Earliest) J:55241 Minowada G, et al., Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development. 1999 Oct;126(20):4465-75
(Latest) J:193110 Griffin JN, et al., Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 1;374(1):185-97
All references(130)