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Spry1 Gene Detail
Summary
  • Symbol
    Spry1
  • Name
    sprouty RTK signaling antagonist 1
  • Synonyms
    sprouty1, sprouty 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345139
    NCBI Gene: 24063
  • Gene Overview
    MyGene.info: SPRY1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:37639947-37644598 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4652 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 18.46 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SPRY1, sprouty RTK signaling antagonist 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SPRY1, sprouty RTK signaling antagonist 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hSPRY1
  • Links
    NCBI Gene ID: 10252
    neXtProt AC: NX_O43609
    UniProt: O43609

  • Chr Location
    4q28.1; chr4:123396791-123403760 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display postnatal lethality, premature death, abnormal kidney morphology and development with multiple ectopic ureteric buds, multiple ureters, and hydroureter.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000007497 VEGA Gene Model | MGI Sequence Detail 4652 C57BL/6J ±  kb
    transcript OTTMUST00000017292 VEGA | MGI Sequence Detail 2481 Not Applicable  
    polypeptide OTTMUSP00000007984 VEGA | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      82 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 37
      Primer pair 1
      Other 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 177
      Developmental Gene Expression 117
      Diseases 2
      Gene Ontology 9
      Phenotypes 49
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:254919 Zhang H, et al., An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis. Elife. 2017 Nov 15;6(None):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory