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Spry1 Gene Detail
Summary
  • Symbol
    Spry1
  • Name
    sprouty homolog 1 (Drosophila)
  • Synonyms
    sprouty1, sprouty 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345139
    NCBI Gene: 24063
  • Gene Overview
    MyGene.info: SPRY1
Location & Maps
more
  • Sequence Map
    Chr3:37639947-37644598 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4652 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 18.46 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SPRY1, sprouty RTK signaling antagonist 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SPRY1, sprouty RTK signaling antagonist 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hSPRY1
  • Links
    NCBI Gene ID: 10252
    neXtProt AC: NX_O43609

  • Chr Location
    4q28.1; chr4:123396791-123403760 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    2 involving Spry1
  • Incidental Mutations
    APF
Homozygous null mice display postnatal lethality, premature death, abnormal kidney morphology and development with multiple ectopic ureteric buds, multiple ureters, and hydroureter.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007497 VEGA Gene Model | MGI Sequence Detail 4652 C57BL/6J ±  kb
transcript OTTMUST00000017293 VEGA | MGI Sequence Detail 2451 Not Applicable  
polypeptide OTTMUSP00000007985 VEGA | MGI Sequence Detail 313 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    82 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 37
    Primer pair 1
    Other 3

    Microarray probesets 2
References
more
  • Summaries
    All 156
    Developmental Gene Expression 107
    Diseases 1
    Gene Ontology 9
    Phenotypes 43
  • Earliest
    J:55241 Minowada G, et al., Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development. 1999 Oct;126(20):4465-75
  • Latest
    J:226692 Wright KD, et al., Cooperative and independent functions of FGF and Wnt signaling during early inner ear development. BMC Dev Biol. 2015;15:33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory