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Pglyrp1
Gene Detail
 Symbol
Name
ID
Pglyrp1
peptidoglycan recognition protein 1
MGI:1345092
Synonyms peptidoglycan recognition protein, PGRP-S, Tag7, Tasg7, Tnfsf3l
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.38 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:18884690-18890438 bp, + strand
From NCBI annotation of GRCm38

  5749 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: peptidoglycan recognition protein, PGRP-S type
Gene Tree: Pglyrp1

Human
homologs
Human Homolog PGLYRP1, peptidoglycan recognition protein 1
NCBI Gene ID 8993
neXtProt AC  NX_O75594
Human Synonyms  PGLYRP, PGRP, PGRPS, PGRP-S, TAG7, TNFSF3L
Human Chr (Location)  19q13.2-q13.3; chr19:46019153-46023298 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice show a defect in neutrophil killing and increased susceptibility to infection with non-pathogenic gram-positive bacteria or DSS-induced colitis.
 
Interactions
Pglyrp1 interacts with 7 markers (Mir328, Mir450-2, Mir615, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process apoptotic process, defense response to bacterium, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, N-acetylmuramoyl-L-alanine amidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (145)    Tissues (111)    Images (28)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 145
cDNA source data(53)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(53) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030413 (Evidence)
Entrez Gene21946 (Evidence)
UniGene21855
DFCITC1581549, TC1634378
DoTSDT.491985, DT.91393161
NIA Mouse Gene IndexU007745
Consensus CDS ProjectCCDS20881.1
International Mouse Knockout Project StatusPglyrp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21946 NCBI Gene Model | MGI Sequence Detail 5749 C57BL/6J ±  kb
transcript NM_009402 RefSeq | MGI Sequence Detail 681 C57BL/6 
polypeptide O88593 UniProt | EBI | MGI Sequence Detail 182 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002502 N-acetylmuramoyl-L-alanine amidase domain
InterPro IPR015510 Peptidoglycan recognition protein
InterPro IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
InterPro IPR017331 Peptidoglycan recognition protein, PGRP-S
Protein Ontology PR:000012610 peptidoglycan recognition protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:33630 Kustikova OS, et al., [Cloning of the tag7 gene expressed in metastatic mouse tumors]. Genetika. 1996 May;32(5):621-8
(Latest) J:194465 Park SY, et al., Peptidoglycan recognition protein 1 enhances experimental asthma by promoting th2 and th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses. J Immunol. 2013 Apr 1;190(7):3480-92
All references(42)
Other
accession IDs
MGD-MRK-35884, MGI:107415, MGI:1306810

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory