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Pglyrp1 Gene Detail
Summary
  • Symbol
    Pglyrp1
  • Name
    peptidoglycan recognition protein 1
  • Synonyms
    peptidoglycan recognition protein, PGRP-S, Tag7, Tasg7, Tnfsf3l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345092
    NCBI Gene: 21946
  • Gene Overview
    MyGene.info: PGLYRP1
Location & Maps
more
  • Sequence Map
    Chr7:18871331-18890459 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19129 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.38 cM, cytoband A3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PGLYRP1, peptidoglycan recognition protein 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PGLYRP1, peptidoglycan recognition protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PGLYRP, PGRP, PGRPS, PGRP-S, TAG7, TNFSF3L
  • Links
    NCBI Gene ID: 8993
    neXtProt AC: NX_O75594

  • Chr Location
    19q13.32; chr19:46019153-46023298 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice show a defect in neutrophil killing and increased susceptibility to infection with non-pathogenic gram-positive bacteria or DSS-induced colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058432 VEGA Gene Model | MGI Sequence Detail 19129 C57BL/6J ±  kb
transcript OTTMUST00000143497 VEGA | MGI Sequence Detail 694 Not Applicable  
polypeptide OTTMUSP00000074799 VEGA | MGI Sequence Detail 182 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    202 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012610 peptidoglycan recognition protein 1
  • InterPro Domains
    IPR002502 N-acetylmuramoyl-L-alanine amidase domain
    IPR015510 Peptidoglycan recognition protein
    IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
    IPR017331 Peptidoglycan recognition protein, PGRP-S
Molecular
Reagents
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  • All nucleic 55
    Genomic 1
    cDNA 53
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-35884, MGI:107415, MGI:1306810
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:33630 Kustikova OS, et al., [Cloning of the tag7 gene expressed in metastatic mouse tumors]. Genetika. 1996 May;32(5):621-8
  • Latest
    J:231567 Yao X, et al., Peptidoglycan recognition protein 1 promotes house dust mite-induced airway inflammation in mice. Am J Respir Cell Mol Biol. 2013 Dec;49(6):902-11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory