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Chic1 Gene Detail
Summary
  • Symbol
    Chic1
  • Name
    cysteine-rich hydrophobic domain 1
  • Synonyms
    Brx, Gm10454
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344694
    NCBI Gene: 12212
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:103356476-103396092 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 46.08 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344694
protein coding gene ChrX:103356337-103409092 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035983
protein coding gene ChrX:99997598-100037202 (+)
A/J MGP_AJ_G0035964
protein coding gene ChrX:99935495-99976721 (+)
AKR/J MGP_AKRJ_G0035882
protein coding gene ChrX:102945701-102987029 (+)
BALB/cJ MGP_BALBcJ_G0035954
protein coding gene ChrX:98736214-98775997 (+)
C3H/HeJ MGP_C3HHeJ_G0035660
protein coding gene ChrX:100461734-100502976 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036480
protein coding gene ChrX:102965804-103005631 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033308
protein coding gene ChrX:97580359-97617539 (+)
CAST/EiJ MGP_CASTEiJ_G0034946
protein coding gene ChrX:84730852-84774109 (+)
CBA/J MGP_CBAJ_G0035635
protein coding gene ChrX:106135227-106179251 (+)
DBA/2J MGP_DBA2J_G0035789
protein coding gene ChrX:99181833-99221686 (+)
FVB/NJ MGP_FVBNJ_G0035730
protein coding gene ChrX:98484114-98525048 (+)
LP/J MGP_LPJ_G0035882
protein coding gene ChrX:101017674-101057652 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035762
protein coding gene ChrX:110794256-110836866 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036506
protein coding gene ChrX:99685405-99726688 (+)
PWK/PhJ MGP_PWKPhJ_G0034644
protein coding gene ChrX:82315567-82353591 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034472
protein coding gene ChrX:85431457-85470533 (+)
WSB/EiJ MGP_WSBEiJ_G0035086
protein coding gene ChrX:98411379-98451218 (+)



Homology
more
  • Human Ortholog
    CHIC1, cysteine rich hydrophobic domain 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHIC1, cysteine rich hydrophobic domain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRX
  • Links
    NCBI Gene ID: 53344
    neXtProt AC: NX_Q5VXU3
    UniProt: Q5VXU3

  • Chr Location
    Xq13.2; chrX:73563045-73687109 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 47543
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CHIC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 images
    7 phenotype references
Male chimeras hemizygous for a gene trapped allele appear normal at E9.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031327 Ensembl Gene Model | MGI Sequence Detail 39617 C57BL/6J ±  kb
transcript ENSMUST00000116547 Ensembl | MGI Sequence Detail 7375 Not Applicable  
polypeptide ENSMUSP00000112246 Ensembl | MGI Sequence Detail 227 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000030413 cysteine-rich hydrophobic domain-containing protein 1
  • InterPro Domains
    IPR039735 Cysteine-rich hydrophobic domain-containing protein 1/2
    IPR019383 Golgin subfamily A member 7/ERF4
Molecular
Reagents
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  • All nucleic 39
    Genomic 14
    cDNA 25

    Microarray probesets 6
Other
Accession IDs
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MGI:1099205, MGI:3642521
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 1
    Phenotypes 7
  • Earliest
    J:43485 Simmler MC, et al., Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region. Mamm Genome. 1997 Oct;8(10):760-6
  • Latest
    J:205757 Kobayashi S, et al., Identification of an imprinted gene cluster in the X-inactivation center. PLoS One. 2013;8(8):e71222

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory