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Esyt1 Gene Detail
Summary
  • Symbol
    Esyt1
  • Name
    extended synaptotagmin-like protein 1
  • Synonyms
    Fam62a, Mbc2, vp115
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344426
    NCBI Gene: 23943
  • Gene Overview
    MyGene.info: ESYT1
Location & Maps
more
  • Sequence Map
    Chr10:128510248-128525859 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15612 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 76.85 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ESYT1, extended synaptotagmin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ESYT1, extended synaptotagmin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FAM62A, MBC2
  • Links
    NCBI Gene ID: 23344
    neXtProt AC: NX_Q9BSJ8

  • Chr Location
    12q13.2; chr12:56128202-56144676 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 23943 NCBI Gene Model | MGI Sequence Detail 15612 C57BL/6J ±  kb
transcript NM_011843 RefSeq | MGI Sequence Detail 3687 C57BL/6  
polypeptide Q3U7R1 UniProt | EBI | MGI Sequence Detail 1092 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    135 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000030860 extended synaptotagmin-1
  • InterPro Domains
    IPR000008 C2 domain
    IPR031468 Synaptotagmin-like mitochondrial-lipid-binding domain
Molecular
Reagents
less
  • All nucleic 102
    cDNA 102

    Microarray probesets 5
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:55426 Morris NJ, et al., Cloning and preliminary characterization of a 121 kDa protein with multiple predicted C2 domains. Biochim Biophys Acta. 1999 May 18;1431(2):525-30
  • Latest
    J:232605 Herdman C, et al., Loss of Extended Synaptotagmins ESyt2 and ESyt3 does not affect mouse development or viability, but in vitro cell migration and survival under stress are affected. Cell Cycle. 2014;13(16):2616-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory