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Osr1
Gene Detail
 Symbol
Name
ID
Osr1
odd-skipped related 1 (Drosophila)
MGI:1344424
Synonyms Odd1
Feature Type protein coding gene
Genetic Map
Chromosome 12
4.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:9574442-9581499 bp, + strand
From Ensembl annotation of GRCm38

  7058 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8035  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Osr1

Human
homologs
Human Homolog OSR1, odd-skipped related transciption factor 1
NCBI Gene ID 130497
neXtProt AC  NX_Q8TAX0
Human Synonyms  ODD
Human Chr (Location)  2p24.1; chr2:19351485-19358611 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation fail to form atrial septum and exhibit dilated atria with hypoplastic venous valves and blood backflow from the heart into systemic veins. Complete agenesis of adrenal glands, metanephric kidneys, gonads, and defects in pericardium formation are also observed.
 
Interactions
Osr1 interacts with 158 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (54 annotations)
Process cell differentiation, cell proliferation involved in kidney development, ...
Component nucleus
Function metal ion binding, nucleic acid binding
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (401)    Tissues (140)    Images (54)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 19, 20, 21, 23, 28
Assay TypeResults
RNA in situ 385
Northern blot 1
RT-PCR 15
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(26) Primer pair(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000048387 (Evidence)
Entrez Gene23967 (Evidence)
UniGene45055
DFCITC1583262, TC1619957
DoTSDT.529641
NIA Mouse Gene IndexU013750
Consensus CDS ProjectCCDS25809.1
International Mouse Knockout Project StatusOsr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048387 Ensembl Gene Model | MGI Sequence Detail 7058 C57BL/6J ±  kb
transcript ENSMUST00000057021 Ensembl | MGI Sequence Detail 2010 Not Applicable 
polypeptide ENSMUSP00000055486 Ensembl | MGI Sequence Detail 266 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000012061 protein odd-skipped-related 1
References (Earliest) J:56366 So PL, et al., Cloning and expression analysis of a mouse gene related to Drosophila odd-skipped. Mech Dev. 1999 Jun;84(1-2):157-60
(Latest) J:208647 Xu J, et al., Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development. 2014 Apr;141(7):1442-52
All references(66)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory