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Cib1
Gene Detail
Symbol

Name
ID
Cib1
calcium and integrin binding 1 (calmyrin)
MGI:1344418
Synonyms
Kip
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.55 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:80227156-80232813 bp, - strand
From VEGA annotation of GRCm38

  5658 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4654  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Cib1

Human
homologs
Human Homolog CIB1, calcium and integrin binding 1 (calmyrin)
NCBI Gene ID 10519
neXtProt AC  NX_Q99828
Human Synonyms  CIB, CIBP, KIP1, PRKDCIP, SIP2-28
Human Chr (Location)  15q25.3-q26; chr15:90230245-90265759 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(11) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in male infertility due to disruption of the haploid phase of spermatogenesis and is associated with small testis size and loss of elongated spermatids and sperm.
 
Interactions
Cib1 interacts with 32 markers (Mir30a, Mir30b, Mir30c-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (82 annotations)
Process angiogenesis, apoptotic process, ...
Component cell periphery, cell projection, ...
Function calcium ion binding, ion channel binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (28)    Tissues (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 28
cDNA source data(136)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(138) Genomic(1) cDNA(136) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022916 (Evidence)
Ensembl Gene ModelENSMUSG00000030538 (Evidence)
Entrez Gene23991 (Evidence)
UniGene30217
DFCITC1592971, TC1575733
DoTSDT.101399678, DT.495905
NIA Mouse Gene IndexU028757
Consensus CDS ProjectCCDS21392.1
International Mouse Knockout Project StatusCib1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022916 VEGA Gene Model | MGI Sequence Detail 5658 C57BL/6J ±  kb
transcript OTTMUST00000055107 VEGA | MGI Sequence Detail 1038 Not Applicable 
polypeptide OTTMUSP00000026344 VEGA | MGI Sequence Detail 191 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000005490 calcium and integrin-binding protein 1
References
(Earliest) J:53819 Saito T, et al., Structure, expression profile, and chromosomal location of a mouse gene homologous to human DNA-PKcs interacting protein (KIP) gene. Mamm Genome. 1999 Mar;10(3):315-7
(Latest) J:181770 Kostyak JC, et al., Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration. Blood. 2012 Jan 19;119(3):838-46
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory