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Cib1 Gene Detail
Summary
  • Symbol
    Cib1
  • Name
    calcium and integrin binding 1 (calmyrin)
  • Synonyms
    Kip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344418
    NCBI Gene: 23991
  • Gene Overview
    MyGene.info: CIB1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:80227156-80232805 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.55 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344418
protein coding gene Chr7:80227147-80232813 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032404
protein coding gene Chr7:82190166-82195806 (-)
A/J MGP_AJ_G0032383
protein coding gene Chr7:80268896-80274548 (-)
AKR/J MGP_AKRJ_G0032319
protein coding gene Chr7:82005768-82011420 (-)
BALB/cJ MGP_BALBcJ_G0032395
protein coding gene Chr7:79945428-79951080 (-)
C3H/HeJ MGP_C3HHeJ_G0032108
protein coding gene Chr7:82654110-82659750 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032887
protein coding gene Chr7:85413711-85419365 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029895
protein coding gene Chr7:82786498-82792079 (-)
CAST/EiJ MGP_CASTEiJ_G0031436
protein coding gene Chr7:73535803-73541450 (-)
CBA/J MGP_CBAJ_G0032074
protein coding gene Chr7:88263283-88268923 (-)
DBA/2J MGP_DBA2J_G0032229
protein coding gene Chr7:78828612-78834252 (-)
FVB/NJ MGP_FVBNJ_G0032184
protein coding gene Chr7:78741538-78747190 (-)
LP/J MGP_LPJ_G0032310
protein coding gene Chr7:83428064-83433704 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032221
protein coding gene Chr7:88419213-88424853 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032905
protein coding gene Chr7:81439542-81445194 (-)
PWK/PhJ MGP_PWKPhJ_G0031156
protein coding gene Chr7:72011278-72017021 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030997
protein coding gene Chr7:68445796-68451450 (-)
WSB/EiJ MGP_WSBEiJ_G0031554
protein coding gene Chr7:81791481-81797133 (-)



Homology
more
  • Human Ortholog
    CIB1, calcium and integrin binding 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CIB1, calcium and integrin binding 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CIB, CIBP, KIP1, PRKDCIP, SIP2-28
  • Links
    NCBI Gene ID: 10519
    neXtProt AC: NX_Q99828
    UniProt: Q99828

  • Chr Location
    15q26.1; chr15:90230245-90265759 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4654
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CIB1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in male infertility due to disruption of the haploid phase of spermatogenesis and is associated with small testis size and loss of elongated spermatids and sperm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23991 NCBI Gene Model | MGI Sequence Detail 5650 C57BL/6J ±  kb
    transcript NM_011870 RefSeq | MGI Sequence Detail 1055 Not Specified  
    polypeptide Q9Z0F4 UniProt | EBI | MGI Sequence Detail 191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 139
      Genomic 1
      cDNA 137
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 24
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:246833 Naik MU, et al., Binding of CIB1 to the alphaIIb tail of alphaIIbbeta3 is required for FAK recruitment and activation in platelets. PLoS One. 2017;12(5):e0176602

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory