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Cib1 Gene Detail
Summary
  • Symbol
    Cib1
  • Name
    calcium and integrin binding 1
  • Synonyms
    Kip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344418
    NCBI Gene: 23991
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:79876904-79882553 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.55 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344418
 protein coding gene Chr7:79876895-79882561 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032404
 protein coding gene Chr7:82190166-82195806 (-)
A/J MGP_AJ_G0032383
 protein coding gene Chr7:80268896-80274548 (-)
AKR/J MGP_AKRJ_G0032319
 protein coding gene Chr7:82005768-82011420 (-)
BALB/cJ MGP_BALBcJ_G0032395
 protein coding gene Chr7:79945428-79951080 (-)
C3H/HeJ MGP_C3HHeJ_G0032108
 protein coding gene Chr7:82654110-82659750 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032887
 protein coding gene Chr7:85413711-85419365 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029895
 protein coding gene Chr7:82786498-82792079 (-)
CAST/EiJ MGP_CASTEiJ_G0031436
 protein coding gene Chr7:73535803-73541450 (-)
CBA/J MGP_CBAJ_G0032074
 protein coding gene Chr7:88263283-88268923 (-)
DBA/2J MGP_DBA2J_G0032229
 protein coding gene Chr7:78828612-78834252 (-)
FVB/NJ MGP_FVBNJ_G0032184
 protein coding gene Chr7:78741538-78747190 (-)
LP/J MGP_LPJ_G0032310
 protein coding gene Chr7:83428064-83433704 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032221
 protein coding gene Chr7:88419213-88424853 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032905
 protein coding gene Chr7:81439542-81445194 (-)
PWK/PhJ MGP_PWKPhJ_G0031156
 protein coding gene Chr7:72011278-72017021 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030997
 protein coding gene Chr7:68445796-68451450 (-)
WSB/EiJ MGP_WSBEiJ_G0031554
 protein coding gene Chr7:81791481-81797133 (-)



Homology
more
  • Human Ortholog
    CIB1, calcium and integrin binding 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIB1, calcium and integrin binding 1
  • Synonyms
    CIB, CIBP, EV3, KIP1, PRKDCIP, SIP2-28
  • Links
    NCBI Gene ID: 10519
    neXtProt AC: NX_Q99828
    UniProt: Q99828

  • Chr Location
    15q26.1; chr15:90229975-90265759 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CIB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in male infertility due to disruption of the haploid phase of spermatogenesis and is associated with small testis size and loss of elongated spermatids and sperm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    120
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    50
  • cDNA Data
    137
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23991 NCBI Gene Model | MGI Sequence Detail 5650 C57BL/6J ±  kb
    transcript NM_001421986 RefSeq | MGI Sequence Detail 1462 C57BL/6  
    polypeptide Q9Z0F4 UniProt | EBI | MGI Sequence Detail 191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      Genomic 1
      cDNA 137
      Primer pair 1
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 5
      Gene Ontology 14
      Phenotypes 30
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:307668 Liang X, et al., CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells. Neuron. 2021 Jul 7;109(13):2131-2149.e15
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory