Neu2
Gene Detail

Symbol Name ID

Neu2 neuraminidase 2 MGI:1344417

Synonyms

brain sialidase, cystolic sialidase, MBS, MSS, MTS

Feature Type

protein coding gene

Genetic Map

Chromosome 1

44.44 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:87509889-87597845 bp, + strand From VEGA annotation of GRCm38   87957 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3927  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Neu2

Human homologs

Human Homolog		NEU2, sialidase 2 (cytosolic sialidase)
NCBI Gene ID		4759
neXtProt AC		NX_Q9Y3R4
Human Synonyms		SIAL2
Human Chr (Location)		2q37; chr2:233897382-233899767 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	metabolic process, positive regulation of myoblast differentiation, ...
Component	cytoplasm, cytosol
Function	exo-alpha-(2->3)-sialidase activity, exo-alpha-(2->6)-sialidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (101)    Tissues (99)   
Theiler Stages: 20, 22, 24, 26, 28

Assay Type	Results
RNA in situ	94
RT-PCR	7

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000036754 (Evidence)
Ensembl Gene Model	ENSMUSG00000079434 (Evidence)
Entrez Gene	23956 (Evidence)
UniGene	143717
DFCI	TC1586035, TC1636794
DoTS	DT.60102592, DT.91338099, DT.94232394, DT.99855182
NIA Mouse Gene Index	U000561
EC	3.2.1.18
Consensus CDS Project	CCDS15135.1, CCDS48308.1, CCDS48309.1
International Mouse Knockout Project Status	Neu2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036754	VEGA Gene Model | MGI Sequence Detail	87957	C57BL/6J
transcript	OTTMUST00000094288	VEGA | MGI Sequence Detail	1733	Not Applicable
polypeptide	OTTMUSP00000052401	VEGA | MGI Sequence Detail	385	Not Applicable

All sequences(66) RefSeq(8) UniProt(8)

Polymorphisms

SNPs(27 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011040	Neuraminidase
InterPro	IPR026945	Sialidase-2
InterPro	IPR026856	Sialidase family
Protein Ontology	PR:000011146	sialidase-2

References

(Earliest) J:55763 Fronda CL, et al., Molecular cloning and expression of mouse brain sialidase. Biochem Biophys Res Commun. 1999 May 19;258(3):727-31
(Latest) J:181998 Kakani S, et al., The Gne M712T Mouse as a Model for Human Glomerulopathy. Am J Pathol. 2012 Apr;180(4):1431-40
All references(39)