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Neu2
Gene Detail
 Symbol
Name
ID
Neu2
neuraminidase 2
MGI:1344417
Synonyms brain sialidase, cystolic sialidase, MBS, MSS, MTS
Feature Type protein coding gene
Genetic Map
Chromosome 1
44.44 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:87509889-87597845 bp, + strand
From VEGA annotation of GRCm38

  87957 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3927  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Neu2

Human
homologs
Human Homolog NEU2, sialidase 2 (cytosolic sialidase)
NCBI Gene ID 4759
neXtProt AC  NX_Q9Y3R4
Human Synonyms  SIAL2
Human Chr (Location)  2q37; chr2:233032672-233035057 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Neu2 interacts with 50 markers (Mir194-2, Mir200b, Mir200c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process carbohydrate metabolic process, ganglioside catabolic process, ...
Component cytoplasm, cytosol
Function exo-alpha-(2->3)-sialidase activity, exo-alpha-(2->6)-sialidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (101)    Tissues (100)   
Theiler Stages: 20, 22, 24, 26, 27, 28
Assay TypeResults
RNA in situ 94
RT-PCR 7
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036754 (Evidence)
Ensembl Gene ModelENSMUSG00000079434 (Evidence)
Entrez Gene23956 (Evidence)
UniGene143717
DFCITC1586035, TC1636794
DoTSDT.60102592, DT.91338099, DT.94232394, DT.99855182
NIA Mouse Gene IndexU000561
EC3.2.1.18
Consensus CDS ProjectCCDS15135.1, CCDS48308.1, CCDS48309.1
International Mouse Knockout Project StatusNeu2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036754 VEGA Gene Model | MGI Sequence Detail 87957 C57BL/6J ±  kb
transcript OTTMUST00000094288 VEGA | MGI Sequence Detail 1733 Not Applicable 
polypeptide OTTMUSP00000052401 VEGA | MGI Sequence Detail 385 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(12) UniProt(8)
Polymorphisms SNPs within 2kb(430 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026945 Sialidase-2
InterPro IPR026856 Sialidase family
InterPro IPR011040 Sialidases
Protein Ontology PR:000011146 sialidase-2
References (Earliest) J:55763 Fronda CL, et al., Molecular cloning and expression of mouse brain sialidase. Biochem Biophys Res Commun. 1999 May 19;258(3):727-31
(Latest) J:181998 Kakani S, et al., The Gne M712T Mouse as a Model for Human Glomerulopathy. Am J Pathol. 2012 Apr;180(4):1431-40
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory