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Neu2 Gene Detail
Summary
  • Symbol
    Neu2
  • Name
    neuraminidase 2
  • Synonyms
    brain sialidase, cystolic sialidase, MBS, MSS, MTS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344417
    NCBI Gene: 23956
  • Gene Overview
    MyGene.info: NEU2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87574027-87597845 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.44 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344417
protein coding gene Chr1:87509889-87597845 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016267
protein coding gene Chr1:88872027-88969293 (+)
A/J MGP_AJ_G0016248
protein coding gene Chr1:85541269-85630015 (+)
AKR/J MGP_AKRJ_G0016209
protein coding gene Chr1:88065547-88155887 (+)
BALB/cJ MGP_BALBcJ_G0016205
protein coding gene Chr1:85663610-85752066 (+)
C3H/HeJ MGP_C3HHeJ_G0016033
protein coding gene Chr1:88326049-88419505 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016661
protein coding gene Chr1:92183040-92266966 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014383
protein coding gene Chr1:79992528-80078886 (+)
CAST/EiJ MGP_CASTEiJ_G0015618
protein coding gene Chr1:87540681-87635038 (+)
CBA/J MGP_CBAJ_G0016009
protein coding gene Chr1:95108114-95208900 (+)
DBA/2J MGP_DBA2J_G0016112
protein coding gene Chr1:84841343-84928871 (+)
FVB/NJ MGP_FVBNJ_G0016111
protein coding gene Chr1:83903149-83989759 (+)
LP/J MGP_LPJ_G0016183
protein coding gene Chr1:89930981-90014007 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016137
protein coding gene Chr1:98386367-98489057 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016704
protein coding gene Chr1:88177279-88271800 (+)
PWK/PhJ MGP_PWKPhJ_G0015405
protein coding gene Chr1:84142518-84223388 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015185
protein coding gene Chr1:87092283-87175339 (+)
WSB/EiJ MGP_WSBEiJ_G0015682
protein coding gene Chr1:87850057-87941182 (+)



Homology
more
  • Human Ortholog
    NEU2, neuraminidase 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NEU2, neuraminidase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SIAL2
  • Links
    NCBI Gene ID: 4759
    neXtProt AC: NX_Q9Y3R4
    UniProt: Q9Y3R4

  • Chr Location
    2q37.1; chr2:233032672-233035057 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 23956 NCBI Gene Model | MGI Sequence Detail 23819 C57BL/6J ±  kb
transcript NM_001160165 RefSeq | MGI Sequence Detail 1748 C57BL/6  
polypeptide Q9JMH3 UniProt | EBI | MGI Sequence Detail 379 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:181998 Kakani S, et al., The Gne M712T Mouse as a Model for Human Glomerulopathy. Am J Pathol. 2012 Apr;180(4):1431-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory