Ash2l
Gene Detail

Symbol Name ID

Ash2l ash2 (absent, small, or homeotic)-like (Drosophila) MGI:1344416

Feature Type

protein coding gene

Genetic Map

Chromosome 8

14.17 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:25816191-25847694 bp, - strand From VEGA annotation of GRCm38   31504 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ash2l

Human homologs

Human Homolog		ASH2L, ash2 (absent, small, or homeotic)-like (Drosophila)
NCBI Gene ID		9070
neXtProt AC		NX_Q9UBL3
Human Synonyms		ASH2, ASH2L1, ASH2L2, Bre2
Human Chr (Location)		8p11.2; chr8:37963011-37997598 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(51) : Targeted(1) Gene trapped(50)
 

Mice homozygous for a gene trapped allele die before E8.5-E11.5.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	chromatin modification, histone H3-K4 methylation, ...
Component	histone methyltransferase complex, MLL1 complex, ...
Function	DNA binding, histone methyltransferase activity (H3-K4 specific), ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (57)    Tissues (39)    Images (22)
Theiler Stages: 5, 15, 17, 18, 19, 21, 23

Assay Type	Results
RNA in situ	57

cDNA source data(190)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(190) cDNA(190)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022959 (Evidence)
Ensembl Gene Model	ENSMUSG00000031575 (Evidence)
Entrez Gene	23808 (Evidence)
UniGene	27706
DFCI	TC1572482
DoTS	DT.532660, DT.94273060, DT.94406832, DT.97406356
NIA Mouse Gene Index	U029672
Consensus CDS Project	CCDS40307.1, CCDS40308.1
International Mouse Knockout Project Status	Ash2l

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022959	VEGA Gene Model | MGI Sequence Detail	31504	C57BL/6J
transcript	OTTMUST00000055228	VEGA | MGI Sequence Detail	3104	Not Applicable
polypeptide	OTTMUSP00000026421	VEGA | MGI Sequence Detail	623	Not Applicable

All sequences(77) RefSeq(4) UniProt(8)

Polymorphisms

SNPs(76 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001870	B30.2/SPRY domain
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR003877	SPla/RYanodine receptor SPRY
InterPro	IPR018355	SPla/RYanodine receptor subgroup
Protein Ontology	PR:000004371	set1/Ash2 histone methyltransferase complex subunit ASH2

References

(Earliest) J:56105 Ikegawa S, et al., Cloning and characterization of ASH2L and Ash2l, human and mouse homologs of the Drosophila ash2 gene. Cytogenet Cell Genet. 1999;84(3-4):167-72
(Latest) J:186535 Herriges JC, et al., Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
All references(51)