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Ash2l
Gene Detail
 Symbol
Name
ID
Ash2l
ash2 (absent, small, or homeotic)-like (Drosophila)
MGI:1344416
Feature Type protein coding gene
Genetic Map
Chromosome 8
14.17 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:25816191-25847694 bp, - strand
From VEGA annotation of GRCm38

  31504 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ash2l

Human
homologs
Human Homolog ASH2L, ash2 (absent, small, or homeotic)-like (Drosophila)
NCBI Gene ID 9070
neXtProt AC  NX_Q9UBL3
Human Synonyms  ASH2, ASH2L1, ASH2L2, Bre2
Human Chr (Location)  8p11.2; chr8:38104965-38140080 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(51) : Gene trapped(50) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele die before E8.5-E11.5.
 
Interactions
Ash2l interacts with 283 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular response to DNA damage stimulus, chromatin modification, ...
Component histone methyltransferase complex, MLL1 complex, ...
Function DNA binding, histone methyltransferase activity (H3-K4 specific), ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (57)    Tissues (39)    Images (22)
Theiler Stages: 5, 15, 17, 18, 19, 21, 23
Assay TypeResults
RNA in situ 57
cDNA source data(185)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(185) cDNA(185)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022959 (Evidence)
Ensembl Gene ModelENSMUSG00000031575 (Evidence)
Entrez Gene23808 (Evidence)
UniGene27706
DFCITC1572482, TC1623898
DoTSDT.532660, DT.94273060, DT.94406832, DT.97406356
NIA Mouse Gene IndexU029672
Consensus CDS ProjectCCDS40307.1, CCDS40308.1
International Mouse Knockout Project StatusAsh2l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022959 VEGA Gene Model | MGI Sequence Detail 31504 C57BL/6J ±  kb
transcript OTTMUST00000055228 VEGA | MGI Sequence Detail 3104 Not Applicable 
polypeptide OTTMUSP00000026421 VEGA | MGI Sequence Detail 623 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(6) UniProt(8)
Polymorphisms SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001870 B30.2/SPRY domain
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR003877 SPla/RYanodine receptor SPRY
InterPro IPR018355 SPla/RYanodine receptor subgroup
Protein Ontology PR:000004371 set1/Ash2 histone methyltransferase complex subunit ASH2
References (Earliest) J:56105 Ikegawa S, et al., Cloning and characterization of ASH2L and Ash2l, human and mouse homologs of the Drosophila ash2 gene. Cytogenet Cell Genet. 1999;84(3-4):167-72
(Latest) J:197108 Wan M, et al., The trithorax group protein Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells. J Biol Chem. 2013 Feb 15;288(7):5039-48
All references(53)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory