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Sra1 Gene Detail
Summary
  • Symbol
    Sra1
  • Name
    steroid receptor RNA activator 1
  • Synonyms
    Srap
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344414
    NCBI Gene: 24068
  • Gene Overview
    MyGene.info: SRA1
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr18:36667187-36670311 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344414
protein coding gene Chr18:36666681-36679366 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024282
protein coding gene Chr18:35075013-35086268 (-)
A/J MGP_AJ_G0024248
protein coding gene Chr18:33837331-33849787 (-)
AKR/J MGP_AKRJ_G0024216
protein coding gene Chr18:34784954-34796233 (-)
BALB/cJ MGP_BALBcJ_G0024248
protein coding gene Chr18:33889688-33902470 (-)
C3H/HeJ MGP_C3HHeJ_G0024015
protein coding gene Chr18:34850354-34862681 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024689
protein coding gene Chr18:36304820-36317594 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022129
protein coding gene Chr18:33931880-33942512 (-)
CAST/EiJ MGP_CASTEiJ_G0023490
protein coding gene Chr18:34860753-34876575 (-)
CBA/J MGP_CBAJ_G0023983
protein coding gene Chr18:37380140-37392580 (-)
DBA/2J MGP_DBA2J_G0024115
protein coding gene Chr18:33460362-33471687 (-)
FVB/NJ MGP_FVBNJ_G0024082
protein coding gene Chr18:33166956-33178204 (-)
LP/J MGP_LPJ_G0024197
protein coding gene Chr18:35103985-35116957 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024110
protein coding gene Chr18:38595144-38610125 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024738
protein coding gene Chr18:34658652-34669884 (-)
PWK/PhJ MGP_PWKPhJ_G0023234
protein coding gene Chr18:33713304-33725133 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023041
protein coding gene Chr18:34903884-34915257 (-)
WSB/EiJ MGP_WSBEiJ_G0023553
protein coding gene Chr18:34579104-34590341 (-)



Homology
more
  • Human Ortholog
    SRA1, steroid receptor RNA activator 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SRA1, steroid receptor RNA activator 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    pp7684, SRA, SRAP, STRAA1
  • Links
    NCBI Gene ID: 10011
    neXtProt AC: NX_Q9HD15
    UniProt: Q9HD15

  • Chr Location
    5q31.3; chr5:140550067-140558093 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11906
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SRA1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human SRA1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are protected against diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24068 NCBI Gene Model | MGI Sequence Detail 3125 C57BL/6J ±  kb
    transcript NR_028355 RefSeq | MGI Sequence Detail 1097 C57BL/6  
    polypeptide NP_079567 RefSeq | MGI Sequence Detail 232 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 110

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2147187
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:54002 Lanz RB, et al., A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell. 1999 Apr 2;97(1):17-27
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory