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Ptpn21 Gene Detail
Summary
  • Symbol
    Ptpn21
  • Name
    protein tyrosine phosphatase, non-receptor type 21
  • Synonyms
    PTPD1, PTPRL10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344406
    NCBI Gene: 24000
  • Gene Overview
    MyGene.info: PTPN21
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:98676741-98737405 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 49.88 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    321 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344406
protein coding gene Chr12:98676741-98737614 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020007
protein coding gene Chr12:100075475-100140286 (-)
A/J MGP_AJ_G0019962
protein coding gene Chr12:96310461-96373324 (-)
AKR/J MGP_AKRJ_G0019938
protein coding gene Chr12:98917774-98979783 (-)
BALB/cJ MGP_BALBcJ_G0019948
protein coding gene Chr12:96644185-96706217 (-)
C3H/HeJ MGP_C3HHeJ_G0019750
protein coding gene Chr12:99467418-99531337 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020397
protein coding gene Chr12:103125528-103187026 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018011
protein coding gene Chr12:93284152-93343294 (-)
CAST/EiJ MGP_CASTEiJ_G0019296
protein coding gene Chr12:94516110-94579179 (-)
CBA/J MGP_CBAJ_G0019722
protein coding gene Chr12:106947431-107022858 (-)
DBA/2J MGP_DBA2J_G0019833
protein coding gene Chr12:95735131-95797877 (-)
FVB/NJ MGP_FVBNJ_G0019822
protein coding gene Chr12:94456338-94517619 (-)
LP/J MGP_LPJ_G0019909
protein coding gene Chr12:99903313-99968482 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019864
protein coding gene Chr12:110637403-110700801 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020426
protein coding gene Chr12:98481170-98544470 (-)
PWK/PhJ MGP_PWKPhJ_G0019060
protein coding gene Chr12:90352672-90413756 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018856
protein coding gene Chr12:92642019-92705114 (-)
WSB/EiJ MGP_WSBEiJ_G0019350
protein coding gene Chr12:99310647-99376475 (-)



Homology
more
  • Human Ortholog
    PTPN21, protein tyrosine phosphatase, non-receptor type 21
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTPN21, protein tyrosine phosphatase, non-receptor type 21
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PTPD1, PTPRL10
  • Links
    NCBI Gene ID: 11099
    neXtProt AC: NX_Q16825
    UniProt: Q16825

  • Chr Location
    14q31.3; chr14:88465778-88554779 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021009 Ensembl Gene Model | MGI Sequence Detail 60665 C57BL/6J ±  kb
transcript ENSMUST00000170188 Ensembl | MGI Sequence Detail 5562 Not Applicable  
polypeptide ENSMUSP00000126975 Ensembl | MGI Sequence Detail 1176 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 5
References
more
  • Summaries
    All 31
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:22513 Higashitsuji H, et al., Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1. Oncogene. 1995 Jan 19;10(2):407-14
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory