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Ptpn21 Gene Detail
Summary
  • Symbol
    Ptpn21
  • Name
    protein tyrosine phosphatase, non-receptor type 21
  • Synonyms
    PTPD1, PTPRL10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344406
    NCBI Gene: 24000
  • Gene Overview
    MyGene.info: PTPN21
Location & Maps
more
  • Sequence Map
    Chr12:98676741-98737405 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      60665 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 49.88 cM, cytoband F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PTPN21, protein tyrosine phosphatase, non-receptor type 21
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTPN21, protein tyrosine phosphatase, non-receptor type 21
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PTPD1, PTPRL10
  • Links
    NCBI Gene ID: 11099
    neXtProt AC: NX_Q16825

  • Chr Location
    14q31.3; chr14:88465778-88554779 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    1
  • Gene trapped
    20
  • Targeted
    1
  • Genomic Mutations
    1 involving Ptpn21
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021009 Ensembl Gene Model | MGI Sequence Detail 60665 C57BL/6J ±  kb
transcript ENSMUST00000085116 Ensembl | MGI Sequence Detail 5697 Not Applicable  
polypeptide ENSMUSP00000082197 Ensembl | MGI Sequence Detail 1176 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    321 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 5
References
more
  • Summaries
    All 29
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:22513 Higashitsuji H, et al., Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1. Oncogene. 1995 Jan 19;10(2):407-14
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory