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Agr2
Gene Detail
Symbol

Name
ID
Agr2
anterior gradient 2
MGI:1344405
Synonyms
Gob-4, HAG-2, mAG-2, XAG-2
Feature Type
protein coding gene
Genetic Map
Chromosome 12
16.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:35992907-36004087 bp, + strand
From VEGA annotation of GRCm38

  11181 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4674  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AGR2
Gene Tree: Agr2

Human
homologs
AGR2, anterior gradient 2, protein disulphide isomerase family member
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10551
neXtProt AC: NX_O95994

Human Synonyms: AG2, GOB-4, HAG-2, HEL-S-116, PDIA17, XAG-2

Human Chr (Location): 7p21.3; chr7:16791811-16805114 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit colitis and increased susceptibility to induced colitis. Mice homozygous for another knock-out allele exhibit hyperplasia and defective lineage maturation in the stomach that leads to intestinal obstruction and premature death.
 
Phenotype Images(2)
Interactions
Agr2 interacts with 54 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (12 records)
Data Summary: Results (40)    Tissues (19)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 19
Northern blot 16
RT-PCR 5
cDNA source data(75)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase agr2 ; ZFIN agr2    NEW 
Molecular
reagents
All nucleic(78) cDNA(76) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000019765 (Evidence)
Ensembl Gene Model ENSMUSG00000020581 (Evidence)
Entrez Gene 23795 (Evidence)
UniGene 7244
DFCI TC1574442, TC1725811
DoTS DT.94294348, DT.94294338, DT.94294344
NIA Mouse Gene Index U013867
Consensus CDS Project CCDS25881.1
International Mouse Phenotyping Consortium Status Agr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019765 VEGA Gene Model | MGI Sequence Detail 11181 C57BL/6J ±  kb
transcript OTTMUST00000047269 VEGA | MGI Sequence Detail 784 Not Applicable 
polypeptide OTTMUSP00000021332 VEGA | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(299 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000003843 anterior gradient protein 2
References
(Earliest) J:54318 Thompson DA, et al., hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines. Biochem Biophys Res Commun. 1998 Oct 9;251(1):111-6
(Latest) J:220492 Dong A, et al., Epidermal Growth Factor Receptor (EGFR) Signaling Requires a Specific Endoplasmic Reticulum Thioredoxin for the Post-translational Control of Receptor Presentation to the Cell Surface. J Biol Chem. 2015 Mar 27;290(13):8016-27
All references(50)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory