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Agr2 Gene Detail
Summary
  • Symbol
    Agr2
  • Name
    anterior gradient 2
  • Synonyms
    Gob-4, HAG-2, mAG-2, XAG-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344405
    NCBI Gene: 23795
  • Gene Overview
    MyGene.info: AGR2
Location & Maps
more
  • Sequence Map
    Chr12:35992907-36004087 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11181 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AGR2, anterior gradient 2, protein disulphide isomerase family member
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AGR2, anterior gradient 2, protein disulphide isomerase family member
    Orthology source: HomoloGene
  • Synonyms
    AG2, GOB-4, HAG-2, HEL-S-116, PDIA17, XAG-2
  • Links
    NCBI Gene ID: 10551
    neXtProt AC: NX_O95994

  • Chr Location
    7p21.3; chr7:16791811-16805114 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4674
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: AGR2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 6 alleles in 6 genetic backgrounds
    2 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Targeted
    10
  • Transgenic
    1
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit colitis and increased susceptibility to induced colitis. Mice homozygous for another knock-out allele exhibit hyperplasia and defective lineage maturation in the stomach that leads to intestinal obstruction and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019765 VEGA Gene Model | MGI Sequence Detail 11181 C57BL/6J ±  kb
transcript OTTMUST00000047269 VEGA | MGI Sequence Detail 784 Not Applicable  
polypeptide OTTMUSP00000021332 VEGA | MGI Sequence Detail 175 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    298 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000003843 anterior gradient protein 2
  • InterPro Domains
    IPR012336 Thioredoxin-like fold
Molecular
Reagents
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  • All nucleic 78
    cDNA 76
    Primer pair 1
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 48
    Developmental Gene Expression 13
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:54318 Thompson DA, et al., hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines. Biochem Biophys Res Commun. 1998 Oct 9;251(1):111-6
  • Latest
    J:220492 Dong A, et al., Epidermal Growth Factor Receptor (EGFR) Signaling Requires a Specific Endoplasmic Reticulum Thioredoxin for the Post-translational Control of Receptor Presentation to the Cell Surface. J Biol Chem. 2015 Mar 27;290(13):8016-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory