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Agr2
Gene Detail
 Symbol
Name
ID
Agr2
anterior gradient 2
MGI:1344405
Synonyms Gob-4, HAG-2, mAG-2, XAG-2
Feature Type protein coding gene
Genetic Map
Chromosome 12
16.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:35992907-36004087 bp, + strand
From VEGA annotation of GRCm38

  11181 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4674  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Agr2

Human
homologs
Human Homolog AGR2, anterior gradient 2
NCBI Gene ID 10551
neXtProt AC  NX_O95994
Human Synonyms  AG2, GOB-4, HAG-2, HEL-S-116, PDIA17, XAG-2
Human Chr (Location)  7p21.3; chr7:16791813-16805114 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit colitis and increased susceptibility to induced colitis. Mice homozygous for another knock-out allele exhibit hyperplasia and defective lineage maturation in the stomach that leads to intestinal obstruction and premature death.
 
Phenotype Images(2)
Interactions
Agr2 interacts with 55 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process lung goblet cell differentiation, mucus secretion
Component endoplasmic reticulum, extracellular region, ...
Function dystroglycan binding
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (40)    Tissues (19)    Images (15)
Theiler Stages: 10, 18, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 19
Northern blot 16
RT-PCR 5
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) cDNA(76) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000019765 (Evidence)
Ensembl Gene ModelENSMUSG00000020581 (Evidence)
Entrez Gene23795 (Evidence)
UniGene7244
DFCITC1574442, TC1725811
DoTSDT.94294338, DT.94294344, DT.94294348
NIA Mouse Gene IndexU013867
Consensus CDS ProjectCCDS25881.1
International Mouse Knockout Project StatusAgr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019765 VEGA Gene Model | MGI Sequence Detail 11181 C57BL/6J ±  kb
transcript OTTMUST00000047269 VEGA | MGI Sequence Detail 784 Not Applicable 
polypeptide OTTMUSP00000021332 VEGA | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(299 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000003843 anterior gradient protein 2
References (Earliest) J:54318 Thompson DA, et al., hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines. Biochem Biophys Res Commun. 1998 Oct 9;251(1):111-6
(Latest) J:199980 Norris AM, et al., AGR2 is a SMAD4-suppressible gene that modulates MUC1 levels and promotes the initiation and progression of pancreatic intraepithelial neoplasia. Oncogene. 2013 Aug 15;32(33):3867-76
All references(49)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory