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Agr2 Gene Detail
Summary
  • Symbol
    Agr2
  • Name
    anterior gradient 2
  • Synonyms
    Gob-4, HAG-2, mAG-2, XAG-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344405
    NCBI Gene: 23795
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:36042924-36054080 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 16.18 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344405
 protein coding gene Chr12:36042906-36054086 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019686
 protein coding gene Chr12:34205577-34217887 (+)
A/J MGP_AJ_G0019652
 protein coding gene Chr12:33141081-33152196 (+)
AKR/J MGP_AKRJ_G0019623
 protein coding gene Chr12:34171041-34182322 (+)
BALB/cJ MGP_BALBcJ_G0019630
 protein coding gene Chr12:33336477-33347560 (+)
C3H/HeJ MGP_C3HHeJ_G0019434
 protein coding gene Chr12:34095414-34106625 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020077
 protein coding gene Chr12:35164698-35176730 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017702
 protein coding gene Chr12:32252182-32263494 (+)
CAST/EiJ MGP_CASTEiJ_G0018988
 protein coding gene Chr12:29155276-29167452 (+)
CBA/J MGP_CBAJ_G0019406
 protein coding gene Chr12:36343106-36354293 (+)
DBA/2J MGP_DBA2J_G0019519
 protein coding gene Chr12:32987574-32998671 (+)
FVB/NJ MGP_FVBNJ_G0019508
 protein coding gene Chr12:32704236-32715572 (+)
LP/J MGP_LPJ_G0019589
 protein coding gene Chr12:34286404-34298586 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019544
 protein coding gene Chr12:36007168-36019302 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020117
 protein coding gene Chr12:33685283-33696345 (+)
PWK/PhJ MGP_PWKPhJ_G0018755
 protein coding gene Chr12:27679015-27690428 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018544
 protein coding gene Chr12:28321967-28333132 (+)
WSB/EiJ MGP_WSBEiJ_G0019038
 protein coding gene Chr12:33929543-33941595 (+)



Homology
more
  • Human Ortholog
    AGR2, anterior gradient 2, protein disulphide isomerase family member
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGR2, anterior gradient 2, protein disulphide isomerase family member
  • Synonyms
    AG2, AG-2, GOB-4, HAG-2, HEL-S-116, HPC8, PDIA17, RIFTD, XAG-2
  • Links
    NCBI Gene ID: 10551
    neXtProt AC: NX_O95994
    UniProt: O95994

  • Chr Location
    7p21.1; chr7:16791811-16833433 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 7 alleles in 7 genetic backgrounds
    5 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one of several knock-out alleles exhibit reduced preweaning survival, abnormal gastrointestial morphology affecting secretory cell lineages, and increased susceptibility to induced colitis to varying degrees.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    24
  • cDNA Data
    76
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23795 NCBI Gene Model | MGI Sequence Detail 11157 C57BL/6J ±  kb
    transcript NM_011783 RefSeq | MGI Sequence Detail 760 C57BL/6  
    polypeptide O88312 UniProt | EBI | MGI Sequence Detail 175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 77
      Primer pair 2
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 17
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:54318 Thompson DA, et al., hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines. Biochem Biophys Res Commun. 1998 Oct 9;251(1):111-6
    • Latest
      J:346074 Cloots E, et al., Activation of goblet-cell stress sensor IRE1beta is controlled by the mucin chaperone AGR2. EMBO J. 2024 Mar;43(5):695-718
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory