About   Help   FAQ
Nek4 Gene Detail
Summary
  • Symbol
    Nek4
  • Name
    NIMA (never in mitosis gene a)-related expressed kinase 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344404
    NCBI Gene: 23955
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:30673334-30710778 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.09 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    907 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344404
 protein coding gene Chr14:30673334-30710778 (+)
129S1/SvImJ ENSMUSG00200036643
 protein coding gene Chr14:22495035-22532479 (+)
A/J ENSMUSG00195013249
 protein coding gene Chr14:23570536-23607982 (+)
AKR/J ENSMUSG00220029923
 protein coding gene Chr14:22682902-22720350 (+)
BALB/cJ ENSMUSG00180022607
 protein coding gene Chr14:22659127-22696568 (+)
C3H/HeJ ENSMUSG00175038716
 protein coding gene Chr14:22726439-22763879 (+)
C57BL/6NJ ENSMUSG00215023998
 protein coding gene Chr14:22964818-23002264 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019060
 protein coding gene Chr14:23264995-23301534 (+)
CAST/EiJ ENSTCUG00005022341
 protein coding gene Chr14:22804619-22851807 (+)
CBA/J ENSMUSG00210038737
 protein coding gene Chr14:22969348-23006791 (+)
DBA/2J ENSMUSG00185035622
 protein coding gene Chr14:27238812-27276252 (+)
FVB/NJ ENSMUSG00205017922
 protein coding gene Chr14:22828414-22865850 (+)
JF1/MsJ ENSUMUG00000035389
 protein coding gene Chr14:34497355-34534717 (+)
LP/J ENSMUSG00230037460
 protein coding gene Chr14:34519058-34556499 (+)
NOD/ShiLtJ ENSMUSG00190015919
 protein coding gene Chr14:22982963-23020396 (+)
NZO/HlLtJ ENSMUSG00225035855
 protein coding gene Chr14:28857646-28895087 (+)
PWK/PhJ ENSLUMG00010020205
 protein coding gene Chr14:11093041-11130121 (+)
SPRET/EiJ ENSMSPG00010038211
 protein coding gene Chr14:24630128-24680852 (+)
WSB/EiJ ENSIUOG00005011769
 protein coding gene Chr14:22787582-22825000 (+)



Homology
more
  • Human Ortholog
    NEK4, NIMA related kinase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEK4, NIMA related kinase 4
  • Synonyms
    NRK2, pp12301, STK2
  • Links
    NCBI Gene ID: 6787
    UniProt: P51957

  • Chr Location
    3p21.1; chr3:52708444-52770973 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    612
  • Tissues
    13
  • cDNA Data
    35
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 23955 NCBI Gene Model | MGI Sequence Detail 37445 C57BL/6J ±  kb
transcript NM_011849 RefSeq | MGI Sequence Detail 4267 C57BL/6  
polypeptide Q9Z1J2 UniProt | EBI | MGI Sequence Detail 792 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000011130 serine/threonine-protein kinase Nek4
    (term hierarchy)
  • EC
    2.7.11.1
  • InterPro Domains
    IPR051131 NEK Ser/Thr protein kinase family, NIMA subfamily
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
  • GlyGen
    Q9Z1J2 7 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (5 sites)
Molecular
Reagents
less
  • All nucleic 36
    cDNA 36

    Microarray probesets 7
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 11
  • Earliest
    J:56269 Chen A, et al., NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3. Gene. 1999 Jun 24;234(1):127-37
  • Latest
    J:357971 Yang ZH, et al., NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice. Nat Commun. 2024 Oct 24;15(1):9180
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory