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Lamc3 Gene Detail
Summary
  • Symbol
    Lamc3
  • Name
    laminin gamma 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344394
    NCBI Gene: 23928
  • Gene Overview
    MyGene.info: LAMC3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:31887291-31946539 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 21.93 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    221 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344394
protein coding gene Chr2:31887281-31946539 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025592
protein coding gene Chr2:30276345-30340966 (+)
A/J MGP_AJ_G0025570
protein coding gene Chr2:29019493-29082775 (+)
AKR/J MGP_AKRJ_G0025539
protein coding gene Chr2:30015798-30080084 (+)
BALB/cJ MGP_BALBcJ_G0025566
protein coding gene Chr2:29143808-29206243 (+)
C3H/HeJ MGP_C3HHeJ_G0025327
protein coding gene Chr2:29930689-30001478 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026011
protein coding gene Chr2:31225682-31291124 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023419
protein coding gene Chr2:27760115-27820815 (+)
CAST/EiJ MGP_CASTEiJ_G0024789
protein coding gene Chr2:29877043-29943051 (+)
CBA/J MGP_CBAJ_G0025304
protein coding gene Chr2:32355238-32442910 (+)
DBA/2J MGP_DBA2J_G0025437
protein coding gene Chr2:28794139-28852407 (+)
FVB/NJ MGP_FVBNJ_G0025400
protein coding gene Chr2:28644219-28704886 (+)
LP/J MGP_LPJ_G0025523
protein coding gene Chr2:30150888-30218277 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025430
protein coding gene Chr2:32084147-32149471 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026069
protein coding gene Chr2:29932214-29997119 (+)
PWK/PhJ MGP_PWKPhJ_G0024536
protein coding gene Chr2:28682671-28744134 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024336
protein coding gene Chr2:30071493-30138009 (+)
WSB/EiJ MGP_WSBEiJ_G0024857
protein coding gene Chr2:30106852-30172427 (+)



Homology
more
  • Human Ortholog
    LAMC3, laminin subunit gamma 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LAMC3, laminin subunit gamma 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OCCM
  • Links
    NCBI Gene ID: 10319
    neXtProt AC: NX_Q9Y6N6
    UniProt: Q9Y6N6

  • Chr Location
    9q34.12; chr9:131009117-131093059 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele exhibit abnormal amacrine cell morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026840 Ensembl Gene Model | MGI Sequence Detail 59249 C57BL/6J ±  kb
    transcript ENSMUST00000028187 Ensembl | MGI Sequence Detail 5871 Not Applicable  
    polypeptide ENSMUSP00000028187 Ensembl | MGI Sequence Detail 1581 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 31
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139003, MGI:2139333
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 18
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:54919 Iivanainen A, et al., Molecular cloning and tissue-specific expression of a novel murine laminin gamma3 chain. J Biol Chem. 1999 May 14;274(20):14107-11
    • Latest
      J:251718 Pietila I, et al., Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning. PLoS One. 2016;11(1):e0147171

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory