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Lamc3
Gene Detail
Symbol

Name
ID
Lamc3
laminin gamma 3
MGI:1344394
Feature Type
protein coding gene
Genetic Map
Chromosome 2
21.93 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:31887291-31946539 bp, + strand
From VEGA annotation of GRCm38

  59249 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21222  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: LAMC3
Gene Tree: Lamc3

Human
homologs
LAMC3, laminin, gamma 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10319
neXtProt AC: NX_Q9Y6N6

Human Synonyms: OCCM

Human Chr (Location): 9q34.12; chr9:131009117-131093059 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LAMC3

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele exhibit abnormal amacrine cell morphology.
 
Interactions
Lamc3 interacts with 233 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process astrocyte development, cell adhesion, ...
Component basement membrane, extracellular region, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (192)    Tissues (97)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 178
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN lamc3    NEW 
Molecular
reagents
All nucleic(29) cDNA(29)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000012245 (Evidence)
Ensembl Gene Model ENSMUSG00000026840 (Evidence)
Entrez Gene 23928 (Evidence)
UniGene 302362
DFCI TC1582901
DoTS DT.101148435, DT.110672867, DT.94238344
NIA Mouse Gene Index U001606
Consensus CDS Project CCDS15903.1
International Mouse Phenotyping Consortium Status Lamc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012245 VEGA Gene Model | MGI Sequence Detail 59249 C57BL/6J ±  kb
transcript OTTMUST00000029119 VEGA | MGI Sequence Detail 5871 Not Applicable 
polypeptide OTTMUSP00000013169 VEGA | MGI Sequence Detail 1581 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(221 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002049 EGF-like, laminin
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR000034 Laminin B type IV
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009660 laminin subunit gamma-3
References
(Earliest) J:54919 Iivanainen A, et al., Molecular cloning and tissue-specific expression of a novel murine laminin gamma3 chain. J Biol Chem. 1999 May 14;274(20):14107-11
(Latest) J:203643 Radmanesh F, et al., Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities. Am J Hum Genet. 2013 Mar 7;92(3):468-74
All references(52)
Other
accession IDs
MGI:2139003, MGI:2139333

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory