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Lamc3
Gene Detail
 Symbol
Name
ID
Lamc3
laminin gamma 3
MGI:1344394
Feature Type protein coding gene
Genetic Map
Chromosome 2
21.93 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:31887291-31946539 bp, + strand
From VEGA annotation of GRCm38

  59249 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21222  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lamc3

Human
homologs
Human Homolog LAMC3, laminin, gamma 3
NCBI Gene ID 10319
neXtProt AC  NX_Q9Y6N6
Human Synonyms  OCCM
Human Chr (Location)  9q31-q34; chr9:131009117-131093059 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LAMC3
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele exhibit abnormal amacrine cell morphology.
 
Interactions
Lamc3 interacts with 234 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process astrocyte development, cell adhesion, ...
Component basement membrane, extracellular region, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (186)    Tissues (91)    Images (37)
Theiler Stages: 11, 19, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 178
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) cDNA(29)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000012245 (Evidence)
Ensembl Gene ModelENSMUSG00000026840 (Evidence)
Entrez Gene23928 (Evidence)
UniGene302362
DFCITC1582901
DoTSDT.101148435, DT.110672867, DT.94238344
NIA Mouse Gene IndexU001606
Consensus CDS ProjectCCDS15903.1
International Mouse Knockout Project StatusLamc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012245 VEGA Gene Model | MGI Sequence Detail 59249 C57BL/6J ±  kb
transcript OTTMUST00000029119 VEGA | MGI Sequence Detail 5871 Not Applicable 
polypeptide OTTMUSP00000013169 VEGA | MGI Sequence Detail 1581 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(221 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002049 EGF-like, laminin
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR000034 Laminin B type IV
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009660 laminin subunit gamma-3
References (Earliest) J:54919 Iivanainen A, et al., Molecular cloning and tissue-specific expression of a novel murine laminin gamma3 chain. J Biol Chem. 1999 May 14;274(20):14107-11
(Latest) J:195488 Gnanaguru G, et al., Laminins containing the beta2 and gamma3 chains regulate astrocyte migration and angiogenesis in the retina. Development. 2013 May;140(9):2050-60
All references(52)
Other
accession IDs
MGI:2139003, MGI:2139333

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory