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Oasl2 Gene Detail
Summary
  • Symbol
    Oasl2
  • Name
    2'-5' oligoadenylate synthetase-like 2
  • Synonyms
    M1204, Mmu-OASL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344390
    NCBI Gene: 23962
  • Alliance
    genome feature page
  • Transcription Start Sites
    46 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:115034997-115050295 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 55.99 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    526 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344390
 protein coding gene Chr5:115034995-115050306 (+)
129S1/SvImJ ENSMUSG00200021425
 protein coding gene Chr5:108771878-108775702 (+)
A/J ENSMUSG00195036291
 protein coding gene Chr5:108290001-108293849 (+)
AKR/J ENSMUSG00220050363
 protein coding gene Chr5:107801224-107805048 (+)
BALB/cJ no annotation
C3H/HeJ ENSMUSGG00175055073
 protein coding gene Chr5:110420695-110429653 (+)
C3H/HeJ ENSMUSG00175042853
 protein coding gene Chr5:110415984-110419837 (+)
C57BL/6NJ ENSMUSG00215012072
 protein coding gene Chr5:108436487-108440318 (+)
C57BL/6NJ ENSMUSGG00215055356
 protein coding gene Chr5:108441176-108450133 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027608
 protein coding gene Chr5:107840502-107856107 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210036659
 protein coding gene Chr5:109168017-109171871 (+)
CBA/J ENSMUSGG00210054670
 protein coding gene Chr5:109172729-109181680 (+)
DBA/2J ENSMUSGG00185057852
 protein coding gene Chr5:112226295-112235253 (+)
DBA/2J ENSMUSG00185044728
 protein coding gene Chr5:112221584-112225437 (+)
FVB/NJ ENSMUSG00205023795
 protein coding gene Chr5:108066303-108070156 (+)
FVB/NJ ENSMUSGG00205054232
 protein coding gene Chr5:108071015-108079977 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230042406
 protein coding gene Chr5:116310046-116313870 (+)
NOD/ShiLtJ ENSMUSG00190024484
 protein coding gene Chr5:108104428-108108284 (+)
NZO/HlLtJ ENSMUSGG00225055578
 protein coding gene Chr5:123975734-123984694 (+)
NZO/HlLtJ ENSMUSG00225013357
 protein coding gene Chr5:123971019-123974876 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    OASL2P, 2'-5' oligoadenylate synthetase like 2, pseudogene
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OASL2P, 2'-5' oligoadenylate synthetase like 2, pseudogene
  • Links
    NCBI Gene ID: 111216278

  • Chr Location
    12q24.31; chr12:121053732-121059670 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    654
  • Tissues
    33
  • cDNA Data
    99
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029561 Ensembl Gene Model | MGI Sequence Detail 15299 C57BL/6J ±  kb
    transcript ENSMUST00000031542 Ensembl | MGI Sequence Detail 3123 Not Applicable  
    polypeptide ENSMUSP00000031542 Ensembl | MGI Sequence Detail 508 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000012103 54 kDa 2'-5'-oligoadenylate synthetase-like protein 2
      (term hierarchy)
    • EC
      2.7.7.84
    • InterPro Domains
      IPR006116 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain
      IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
      IPR006117 2-5-oligoadenylate synthetase, C-terminal conserved site
      IPR043518 2-5-oligoadenylate synthetase, N-terminal conserved site
      IPR043519 Nucleotidyltransferase superfamily
      IPR000626 Ubiquitin-like domain
      IPR029071 Ubiquitin-like domain superfamily
    • GlyGen
      Q9Z2F2 1 site
    Molecular
    Reagents
    less
    • All nucleic 104
      cDNA 101
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:379589 Guo X, et al., Heterozygous ADAR mutant mice exhibit RNA sensing-dependent neuroinflammation and phenotypes associated with Aicardi-Goutieres syndrome. iScience. 2026 Feb 20;29(2):114758
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory