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Faim Gene Detail
Summary
  • Symbol
    Faim
  • Name
    Fas apoptotic inhibitory molecule
  • Synonyms
    Faim-L, Faim-S
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344387
    NCBI Gene: 23873
Location & Maps
more
  • Sequence Map
    Chr9:98986373-99002021 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15649 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 51.41 cM, cytoband F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FAIM, Fas apoptotic inhibitory molecule
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FAIM, Fas apoptotic inhibitory molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FAIM1
  • Links
    NCBI Gene ID: 55179
    neXtProt AC: NX_Q9NVQ4

  • Chr Location
    3q22.3; chr3:138608594-138633376 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8018
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FAIM
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Faim
  • Incidental Mutations
Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048179 VEGA Gene Model | MGI Sequence Detail 15649 C57BL/6J ±  kb
transcript OTTMUST00000123710 VEGA | MGI Sequence Detail 803 Not Applicable  
polypeptide OTTMUSP00000067479 VEGA | MGI Sequence Detail 201 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    94 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007327 Fas apoptotic inhibitory molecule 1
  • PDB
  • InterPro Domains
    IPR010695 Fas apoptotic inhibitory molecule 1
Molecular
Reagents
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  • All nucleic 37
    cDNA 34
    Primer pair 1
    Other 2

    Microarray probesets 4
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:53509 Schneider TJ, et al., A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes. J Exp Med. 1999 Mar 15;189(6):949-56
  • Latest
    J:210665 Shi F, et al., A piggyBac insertion disrupts Foxl2 expression that mimics BPES syndrome in mice. Hum Mol Genet. 2014 Jul 15;23(14):3792-800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory