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Med24 Gene Detail
Summary
  • Symbol
    Med24
  • Name
    mediator complex subunit 24
  • Synonyms
    100kDa, D11Ertd307e, DRIP100, Gse2, Pparb2, R75526, Thrap4, Trap100
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344385
    NCBI Gene: 23989
  • Gene Overview
    MyGene.info: MED24
Location & Maps
more
  • Sequence Map
    Chr11:98704591-98729435 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24845 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 62.46 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MED24, mediator complex subunit 24
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MED24, mediator complex subunit 24
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARC100, CRSP100, CRSP4, DRIP100, MED5, THRAP4, TRAP100
  • Links
    NCBI Gene ID: 9862
    neXtProt AC: NX_O75448

  • Chr Location
    17q21.1; chr17:40019097-40054636 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 40795
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MED24
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    6
  • Targeted
    5
  • Genomic Mutations
    1 involving Med24
  • Incidental Mutations
Homozygous mutant mice die prior to birth exhibiting abnormal heart development, neural tube defects, and anemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006403 VEGA Gene Model | MGI Sequence Detail 24845 C57BL/6J ±  kb
transcript OTTMUST00000062370 VEGA | MGI Sequence Detail 3133 Not Applicable  
polypeptide OTTMUSP00000030732 VEGA | MGI Sequence Detail 1006 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    146 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010296 mediator of RNA polymerase II transcription subunit 24
  • InterPro Domains
    IPR021429 Mediator complex, subunit Med24, N-terminal
Molecular
Reagents
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  • All nucleic 243
    cDNA 242
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1098276, MGI:1098829, MGI:2144420, MGI:2144562, MGI:2144713
References
more
  • Summaries
    All 46
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:43245 Gudkov AV, et al., Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3744-8
  • Latest
    J:229253 Spies N, et al., Constraint and divergence of global gene expression in the mammalian embryo. Elife. 2015;4:e05538

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory