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Med24 Gene Detail
Summary
  • Symbol
    Med24
  • Name
    mediator complex subunit 24
  • Synonyms
    100kDa, D11Ertd307e, DRIP100, Gse2, Pparb2, R75526, Thrap4, Trap100
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344385
    NCBI Gene: 23989
  • Gene Overview
    MyGene.info: MED24
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98704591-98729435 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 62.46 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    146 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344385
protein coding gene Chr11:98704591-98729475 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019070
protein coding gene Chr11:101299431-101326219 (-)
A/J MGP_AJ_G0019038
protein coding gene Chr11:97060187-97086037 (-)
AKR/J MGP_AKRJ_G0019008
protein coding gene Chr11:100070219-100095060 (-)
BALB/cJ MGP_BALBcJ_G0019012
protein coding gene Chr11:97556057-97580883 (-)
C3H/HeJ MGP_C3HHeJ_G0018825
protein coding gene Chr11:100210125-100235491 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019463
protein coding gene Chr11:104393626-104420344 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017095
protein coding gene Chr11:94617693-94644949 (-)
CAST/EiJ MGP_CASTEiJ_G0018379
protein coding gene Chr11:101195256-101219917 (-)
CBA/J MGP_CBAJ_G0018796
protein coding gene Chr11:108750378-108775378 (-)
DBA/2J MGP_DBA2J_G0018904
protein coding gene Chr11:96619445-96644282 (-)
FVB/NJ MGP_FVBNJ_G0018893
protein coding gene Chr11:96129779-96154622 (-)
LP/J MGP_LPJ_G0018974
protein coding gene Chr11:101756988-101782646 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018920
protein coding gene Chr11:108467748-108493287 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019503
protein coding gene Chr11:100414245-100440726 (-)
PWK/PhJ MGP_PWKPhJ_G0018150
protein coding gene Chr11:97651845-97677684 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017939
protein coding gene Chr11:100156313-100183494 (-)
WSB/EiJ MGP_WSBEiJ_G0018428
protein coding gene Chr11:100364871-100391240 (-)



Homology
more
  • Human Ortholog
    MED24, mediator complex subunit 24
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MED24, mediator complex subunit 24
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARC100, CRSP100, CRSP4, DRIP100, MED5, THRAP4, TRAP100
  • Links
    NCBI Gene ID: 9862
    neXtProt AC: NX_O75448
    UniProt: O75448

  • Chr Location
    17q21.1; chr17:40019097-40054636 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 40795
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MED24
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice die prior to birth exhibiting abnormal heart development, neural tube defects, and anemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017210 Ensembl Gene Model | MGI Sequence Detail 24845 C57BL/6J ±  kb
    transcript ENSMUST00000100500 Ensembl | MGI Sequence Detail 3133 Not Applicable  
    polypeptide ENSMUSP00000098069 Ensembl | MGI Sequence Detail 1006 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR021429 Mediator complex, subunit Med24, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 243
      cDNA 242
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1098276, MGI:1098829, MGI:2144420, MGI:2144562, MGI:2144713
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:43245 Gudkov AV, et al., Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3744-8
    • Latest
      J:240217 Xu Y, et al., Long-Range Chromosome Interactions Mediated by Cohesin Shape Circadian Gene Expression. PLoS Genet. 2016 May;12(5):e1005992

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory