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Dnajb6
Gene Detail
 Symbol
Name
ID
Dnajb6
DnaJ (Hsp40) homolog, subfamily B, member 6
MGI:1344381
Synonyms mDj4, Mrj
Feature Type protein coding gene
Genetic Map
Chromosome 5
15.27 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:29735688-29786478 bp, + strand
From VEGA annotation of GRCm38

  50791 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38058  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Dnajb6

Human
homologs
Human Homolog DNAJB6, DnaJ (Hsp40) homolog, subfamily B, member 6
NCBI Gene ID 10049
neXtProt AC  NX_O75190
Human Synonyms  DJ4, DnaJ, HHDJ1, HSJ2, HSJ-2, LGMD1D, LGMD1E, MRJ, MSJ-1
Human Chr (Location)  7q36.3; chr7:157337016-157417439 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DNAJB6
Mutations,
alleles, and
phenotypes
All mutations/alleles(134) : Gene trapped(128) Radiation induced(3) Targeted(3)
Genomic Mutations involving Dnajb6 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants died at mid-gestation due to a failure of chorioallantoic fusion at embryonic day 8.5, and thus preventing the formation of a mature placenta.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Dnajb6 interacts with 235 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process actin cytoskeleton organization, chaperone-mediated protein folding, ...
Component cytoplasm, cytosol, ...
Function ATPase activator activity, chaperone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (134)    Tissues (47)    Images (43)
Theiler Stages: 11, 13, 15, 17, 19, 20, 23, 25, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 76
In situ reporter (knock in) 30
Northern blot 27
cDNA source data(218)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(219) Genomic(1) cDNA(218)
Microarray probesets(12)
Other database
links
VEGA Gene ModelOTTMUSG00000024721 (Evidence)
Ensembl Gene ModelENSMUSG00000029131 (Evidence)
Entrez Gene23950 (Evidence)
UniGene290110
DFCITC1573523, TC1577555, TC1588252, TC1754745
Consensus CDS ProjectCCDS19151.1, CCDS19152.1, CCDS39043.1
International Mouse Knockout Project StatusDnajb6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024721 VEGA Gene Model | MGI Sequence Detail 50791 C57BL/6J ±  kb
transcript OTTMUST00000060845 VEGA | MGI Sequence Detail 2918 Not Applicable 
polypeptide OTTMUSP00000029740 VEGA | MGI Sequence Detail 365 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(12) UniProt(4)
Polymorphisms SNPs within 2kb(260 from dbSNP Build 137)    SNPs within 2kb including multiple locations(262)
Protein-related
information
ResourceIDDescription
InterPro IPR001623 DnaJ domain
InterPro IPR018253 DnaJ domain, conserved site
Protein Ontology PR:000006576 DnaJ homolog subfamily B member 6
References (Earliest) J:40477 Baker RK, et al., In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
(Latest) J:177142 Ferdous A, et al., Forkhead factor FoxO1 is essential for placental morphogenesis in the developing embryo. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16307-12
All references(47)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory