About   Help   FAQ
Dnajb6 Gene Detail
Summary
  • Symbol
    Dnajb6
  • Name
    DnaJ heat shock protein family (Hsp40) member B6
  • Synonyms
    mDj4, Mrj
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344381
    NCBI Gene: 23950
  • Gene Overview
    MyGene.info: DNAJB6
Location & Maps
more
  • Sequence Map
    Chr5:29735688-29818134 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      82447 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 15.27 cM, cytoband B1
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DNAJB6, DnaJ heat shock protein family (Hsp40) member B6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DNAJB6, DnaJ heat shock protein family (Hsp40) member B6
    Orthology source: HomoloGene
  • Synonyms
    DJ4, DnaJ, HHDJ1, HSJ2, HSJ-2, LGMD1D, LGMD1E, MRJ, MSJ-1
  • Links
    NCBI Gene ID: 10049
    neXtProt AC: NX_O75190

  • Chr Location
    7q36.3; chr7:157337016-157417439 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DNAJB6 associations

Human Disease Mouse Models
       Muscular Dystrophy, Limb-Girdle, Type 1E; LGMD1E   OMIM: 603511
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    141
  • Chemically induced (other)
    2
  • Gene trapped
    131
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    7 involving Dnajb6
  • Incidental Mutations
Homozygous mutants died at mid-gestation due to a failure of chorioallantoic fusion at embryonic day 8.5, and thus preventing the formation of a mature placenta.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024721 VEGA Gene Model | MGI Sequence Detail 82447 C57BL/6J ±  kb
transcript OTTMUST00000060845 VEGA | MGI Sequence Detail 2918 Not Applicable  
polypeptide OTTMUSP00000029740 VEGA | MGI Sequence Detail 365 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    390 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000006576 DnaJ homolog subfamily B member 6
  • InterPro Domains
    IPR001623 DnaJ domain
    IPR018253 DnaJ domain, conserved site
Molecular
Reagents
less
  • All nucleic 219
    Genomic 1
    cDNA 218

    Microarray probesets 12
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 8
    Phenotypes 36
  • Earliest
    J:40477 Baker RK, et al., In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
  • Latest
    J:177142 Ferdous A, et al., Forkhead factor FoxO1 is essential for placental morphogenesis in the developing embryo. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16307-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory