Rai2 MGI Mouse Gene Detail - MGI:1344378

Symbol

Rai2
Name

retinoic acid induced 2
Synonyms

3f8

Feature Type

protein coding gene
IDs

MGI:1344378
NCBI Gene: 24004
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:160500065-160562492 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 74.07 cM, cytoband F4
Mapping Data

1 experiment

SNPs within 2kb

1178 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344378	protein coding gene	ChrX:160500032-160562492 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036237	protein coding gene	ChrX:159677240-159742749 (+)
A/J	MGP_AJ_G0036207	protein coding gene	ChrX:158928157-158991174 (+)
AKR/J	MGP_AKRJ_G0036135	protein coding gene	ChrX:163996747-164059006 (+)
BALB/cJ	MGP_BALBcJ_G0036200	protein coding gene	ChrX:156954043-157015418 (+)
C3H/HeJ	MGP_C3HHeJ_G0035906	protein coding gene	ChrX:160068163-160133930 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036722	protein coding gene	ChrX:164426723-164493051 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033544	protein coding gene	ChrX:150079874-150143838 (+)
CAST/EiJ	MGP_CASTEiJ_G0035195	protein coding gene	ChrX:139074308-139138302 (+)
CBA/J	MGP_CBAJ_G0035881	protein coding gene	ChrX:169115917-169190296 (+)
DBA/2J	MGP_DBA2J_G0036047	protein coding gene	ChrX:157863702-157925460 (+)
FVB/NJ	MGP_FVBNJ_G0035978	protein coding gene	ChrX:156990093-157051089 (+)
LP/J	MGP_LPJ_G0036132	protein coding gene	ChrX:160881591-160943810 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0036010	protein coding gene	ChrX:177824107-177892249 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036763	protein coding gene	ChrX:159202372-159265575 (+)
PWK/PhJ	MGP_PWKPhJ_G0034893	protein coding gene	ChrX:135910255-135973462 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034714	protein coding gene	ChrX:139507225-139570287 (+)
WSB/EiJ	MGP_WSBEiJ_G0035330	protein coding gene	ChrX:157193939-157257683 (+)

Human Ortholog

RAI2, retinoic acid induced 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAI2, retinoic acid induced 2
Links

HGNC:9835

NCBI Gene ID: 10742

UniProt: Q9Y5P3
Chr Location

Xp22.13; chrX:17800049-17861337 (-) GRCh38

MGI Vertebrate Homology

Rai2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAI2
Gene Tree

Rai2

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Endonuclease-mediated

1
Find Mice (IMSR)

2 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

2
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

10
cDNA Data

9
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rai2

less

All Sequences

40
RefSeq

4
UniProt

2
CCDS

CCDS30507.1

Ensembl

ENSMUSG00000043518 (Evidence)
NCBI Gene

24004

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043518	Ensembl Gene Model \| MGI Sequence Detail	62428	C57BL/6J	± kb
transcript	ENSMUST00000112338	Ensembl \| MGI Sequence Detail	2165	Not Applicable
polypeptide	ENSMUSP00000107957	Ensembl \| MGI Sequence Detail	529	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000013694 retinoic acid-induced protein 2

(term hierarchy)
InterPro Domains

IPR026092 Retinoic acid-induced protein 2/sine oculis-binding protein homologue

less

All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 3

Summaries

All 26

Developmental Gene Expression 3

Gene Ontology 1

Phenotypes 3
Earliest

J:16740 Jonk LJ, et al., Isolation and developmental expression of retinoic-acid-induced genes. Dev Biol. 1994 Feb;161(2):604-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rai2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr162574	ChrX:160500021-160500035 (+)	-37 bp
Tssr162575	ChrX:160500051-160500069 (+)	-5 bp
Tssr162576	ChrX:160500457-160500492 (+)	410 bp
Tssr162577	ChrX:160500494-160500515 (+)	440 bp
Tssr5716	ChrX:160500637-160500653 (+)	580 bp
Tssr162578	ChrX:160560937-160560955 (+)	60,881 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24