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Dand5
Gene Detail
Symbol

Name
ID
Dand5
DAN domain family, member 5
MGI:1344365
Synonyms
Cerl-2, Cerr2, coco, Dte
Feature Type
protein coding gene
Genetic Map
Chromosome 8
41.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:84815405-84822823 bp, - strand
From Ensembl annotation of GRCm38

  7419 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:51883  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

HCOP human homology predictions: DAND5
Protein SuperFamily: cerberus
Gene Tree: Dand5

Human
homologs
DAND5, DAN domain family member 5, BMP antagonist
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 199699
neXtProt AC: NX_Q8N907

Human Synonyms: CER2, CERL2, CKTSF1B3, COCO, CRL2, DANTE, GREM3, SP1

Human Chr (Location): 19p13.2; chr19:12969618-12974753 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(35) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display partial neonatal lethality with left pulmonary isomerism, abnormal heart looping, atrial and ventricular septal defects and thoracic situs inversus and surviving pups display partial premature death with abdominal organ position abnormalities.
 
Interactions
Dand5 interacts with 118 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process atrial septum development, determination of heart left/right asymmetry, ...
Component extracellular region
Function morphogen activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (11)    Tissues (5)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 11
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dand5 ; ZFIN dand5    NEW 
Molecular
reagents
All nucleic(12) cDNA(9) Other(3)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000053226 (Evidence)
Entrez Gene 23863 (Evidence)
UniGene 304252
DFCI TC1588100, TC1636753
DoTS DT.481270, DT.101714877
NIA Mouse Gene Index U115319
Consensus CDS Project CCDS22477.1
International Mouse Phenotyping Consortium Status Dand5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053226 Ensembl Gene Model | MGI Sequence Detail 7419 C57BL/6J ±  kb
transcript ENSMUST00000065539 Ensembl | MGI Sequence Detail 1584 Not Applicable 
polypeptide ENSMUSP00000070057 Ensembl | MGI Sequence Detail 185 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(3) UniProt(2)
Polymorphisms
SNPs within 2kb(152 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016860 Cerberus
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR004133 DAN
Protein Ontology PR:000006271 DAN domain family member 5
References
(Earliest) J:54640 Pearce JJ, et al., A mouse cerberus/Dan-related gene family. Dev Biol. 1999 May 1;209(1):98-110
(Latest) J:214665 Fuller K, et al., Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway. Dev Biol. 2014 Jul 15;391(2):182-95
All references(50)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory