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Dand5
Gene Detail
 Symbol
Name
ID
Dand5
DAN domain family, member 5
MGI:1344365
Synonyms Cerl-2, Cerr2, coco, Dte
Feature Type protein coding gene
Genetic Map
Chromosome 8
41.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:84815405-84822823 bp, - strand
From Ensembl annotation of GRCm38

  7419 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:51883  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: cerberus
Gene Tree: Dand5

Human
homologs
Human Homolog DAND5, DAN domain family member 5, BMP antagonist
NCBI Gene ID 199699
neXtProt AC  NX_Q8N907
Human Synonyms  CER2, CERL2, CKTSF1B3, COCO, CRL2, DANTE, GREM3, SP1
Human Chr (Location)  19p13.2; chr19:12969618-12974753 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(35) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display partial neonatal lethality with left pulmonary isomerism, abnormal heart looping, atrial and ventricular septal defects and thoracic situs inversus and surviving pups display partial premature death with abdominal organ position abnormalities.
 
Interactions
Dand5 interacts with 118 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process atrial septum development, determination of heart left/right asymmetry, ...
Component extracellular region
Function morphogen activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (9)    Tissues (4)    Images (8)
Theiler Stages: 10, 12, 13
Assay TypeResults
RNA in situ 9
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(9) Other(2)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000053226 (Evidence)
Entrez Gene23863 (Evidence)
UniGene304252
DFCITC1588100, TC1636753
DoTSDT.101714877, DT.481270
NIA Mouse Gene IndexU115319
Consensus CDS ProjectCCDS22477.1
International Mouse Knockout Project StatusDand5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053226 Ensembl Gene Model | MGI Sequence Detail 7419 C57BL/6J ±  kb
transcript ENSMUST00000065539 Ensembl | MGI Sequence Detail 1584 Not Applicable 
polypeptide ENSMUSP00000070057 Ensembl | MGI Sequence Detail 185 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(3) UniProt(2)
Polymorphisms SNPs within 2kb(152 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016860 Cerberus
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR004133 DAN
Protein Ontology PR:000006271 DAN domain family member 5
References (Earliest) J:54640 Pearce JJ, et al., A mouse cerberus/Dan-related gene family. Dev Biol. 1999 May 1;209(1):98-110
(Latest) J:200709 Botilde Y, et al., Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo. Dev Biol. 2013 Sep 1;381(1):203-12
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory