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Dand5 Gene Detail
Summary
  • Symbol
    Dand5
  • Name
    DAN domain family member 5, BMP antagonist
  • Synonyms
    Cerl-2, Cerr2, coco, Dte, GREM3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344365
    NCBI Gene: 23863
Location & Maps
more
  • Sequence Map
    Chr8:84815405-84822823 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7419 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.17 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DAND5, DAN domain BMP antagonist family member 5
  • Vertebrate Orthologs
    6
  • Human Ortholog
    DAND5, DAN domain BMP antagonist family member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CER2, CERL2, CKTSF1B3, COCO, CRL2, DANTE, GREM3, SP1
  • Links
    NCBI Gene ID: 199699
    neXtProt AC: NX_Q8N907

  • Chr Location
    19p13.2; chr19:12969618-12974753 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    40
  • Chemically induced (other)
    1
  • Gene trapped
    35
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Dand5
  • Incidental Mutations
Homozygous null mice display partial neonatal lethality with left pulmonary isomerism, abnormal heart looping, atrial and ventricular septal defects and thoracic situs inversus and surviving pups display partial premature death with abdominal organ position abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053226 Ensembl Gene Model | MGI Sequence Detail 7419 C57BL/6J ±  kb
transcript ENSMUST00000065539 Ensembl | MGI Sequence Detail 1584 Not Applicable  
polypeptide ENSMUSP00000070057 Ensembl | MGI Sequence Detail 185 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    150 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 12
    cDNA 9
    Other 3

    Microarray probesets 1
References
more
  • Summaries
    All 52
    Developmental Gene Expression 27
    Gene Ontology 5
    Phenotypes 37
  • Earliest
    J:54640 Pearce JJ, et al., A mouse cerberus/Dan-related gene family. Dev Biol. 1999 May 1;209(1):98-110
  • Latest
    J:233311 Grimes DT, et al., Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination. PLoS Genet. 2016 Jun;12(6):e1006070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory