Dand5
Gene Detail

Symbol Name ID

Dand5 DAN domain family, member 5 MGI:1344365

Synonyms

Cerl-2, Cerr2, coco, Dte

Feature Type

protein coding gene

Genetic Map

Chromosome 8

41.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:84815405-84822823 bp, - strand From Ensembl annotation of GRCm38   7419 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:51883  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: cerberus
Gene Tree: Dand5

Human homologs

Human Homolog		DAND5, DAN domain family member 5, BMP antagonist
NCBI Gene ID		199699
neXtProt AC		NX_Q8N907
Human Synonyms		CER2, CERL2, CKTSF1B3, COCO, CRL2, DANTE, GREM3, SP1
Human Chr (Location)		19p13.2; chr19:13080432-13085567 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(38) : Targeted(3) Gene trapped(35)
 

Homozygous null mice display partial neonatal lethality with left pulmonary isomerism, abnormal heart looping, atrial and ventricular septal defects and thoracic situs inversus and surviving pups display partial premature death with abdominal organ position abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	atrial septum development, determination of heart left/right asymmetry, ...
Component	extracellular region
Function	morphogen activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (9)    Tissues (4)    Images (8)
Theiler Stages: 10, 12, 13

Assay Type	Results
RNA in situ	9

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(9) Other(2)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000053226 (Evidence)
Entrez Gene	23863 (Evidence)
UniGene	304252
DFCI	TC1588100, TC1636753
DoTS	DT.101714877, DT.481270
NIA Mouse Gene Index	U115319
Consensus CDS Project	CCDS22477.1
International Mouse Knockout Project Status	Dand5

Sequences

Length	Strain/Species
genomic	ENSMUSG00000053226	Ensembl Gene Model | MGI Sequence Detail	7419	C57BL/6J
transcript	ENSMUST00000065539	Ensembl | MGI Sequence Detail	1584	Not Applicable
polypeptide	ENSMUSP00000070057	Ensembl | MGI Sequence Detail	185	Not Applicable

All sequences(21) RefSeq(3) UniProt(2)

Polymorphisms

SNPs(34 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016860	Cerberus
InterPro	IPR006207	Cystine knot, C-terminal
InterPro	IPR004133	DAN
Protein Ontology	PR:000006271	DAN domain family member 5

References

(Earliest) J:54640 Pearce JJ, et al., A mouse cerberus/Dan-related gene family. Dev Biol. 1999 May 1;209(1):98-110
(Latest) J:193411 Nakamura T, et al., Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA. Nat Commun. 2012;3:1322
All references(45)