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Usp18
Gene Detail
 Symbol
Name
ID
Usp18
ubiquitin specific peptidase 18
MGI:1344364
Synonyms 1110058H21Rik, UBP43
Feature Type protein coding gene
Genetic Map
Chromosome 6
57.17 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:121245906-121270916 bp, + strand
From Ensembl annotation of GRCm38

  25011 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8047  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Usp18

Human
homologs
Human Homolog USP18, ubiquitin specific peptidase 18
NCBI Gene ID 11274
neXtProt AC  NX_Q9UMW8
Human Synonyms  ISG43, UBP43
Human Chr (Location)  22q11.21; chr22:18149954-18177397 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die prematurely with cellular necrosis in the ependyma, breakdown of blood-brain barrier, hydrocephaly with enlarged ventricles, and severe neurological abnormalities. Mice homozygous for an ENU-induced allele exhibit increased susceptibility to Salmonella infection and LPS.
 
Interactions
Usp18 interacts with 73 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process ISG15-protein conjugation, proteolysis, ...
Component nucleus
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (36)    Tissues (3)    Images (19)
Theiler Stages: 23
Assay TypeResults
RNA in situ 36
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(49) cDNA(48) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030107 (Evidence)
Entrez Gene24110 (Evidence)
UniGene326911
DFCITC1579171
DoTSDT.490235
NIA Mouse Gene IndexU007356
EC3.4.19.-, 3.4.19.12
Consensus CDS ProjectCCDS20489.1
International Mouse Knockout Project StatusUsp18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030107 Ensembl Gene Model | MGI Sequence Detail 25011 C57BL/6J ±  kb
transcript ENSMUST00000032198 Ensembl | MGI Sequence Detail 1770 Not Applicable 
polypeptide ENSMUSP00000032198 Ensembl | MGI Sequence Detail 368 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
Protein Ontology PR:000017156 Ubl carboxyl-terminal hydrolase 18
References (Earliest) J:53884 Liu LQ, et al., A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation. Mol Cell Biol. 1999 Apr;19(4):3029-38
(Latest) J:207464 Basters A, et al., Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15. FEBS J. 2014 Apr;281(7):1918-28
All references(51)
Other
accession IDs
MGI:1916032, MGI:2141633

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory