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Usp18
Gene Detail
 Symbol
Name
ID
Usp18
ubiquitin specific peptidase 18
MGI:1344364
Synonyms 1110058H21Rik, UBP43
Feature Type protein coding gene
Genetic Map
Chromosome 6
57.17 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:121245906-121270916 bp, + strand
From Ensembl annotation of GRCm38

  25011 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8047  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Usp18

Human
homologs
Human Homolog USP18, ubiquitin specific peptidase 18
NCBI Gene ID 11274
neXtProt AC  NX_Q9UMW8
Human Synonyms  ISG43, UBP43
Human Chr (Location)  22q11.21; chr22:18149954-18177397 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die prematurely with cellular necrosis in the ependyma, breakdown of blood-brain barrier, hydrocephaly with enlarged ventricles, and severe neurological abnormalities. Mice homozygous for an ENU-induced allele exhibit increased susceptibility to Salmonella infection and LPS.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process ISG15-protein conjugation, proteolysis, ...
Component nucleus
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (36)    Tissues (3)    Images (19)
Theiler Stages: 23
Assay TypeResults
RNA in situ 36
cDNA source data(48)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(49) cDNA(48) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030107 (Evidence)
Entrez Gene24110 (Evidence)
UniGene326911
DFCITC1579171
DoTSDT.490235
NIA Mouse Gene IndexU007356
EC3.4.19.-, 3.4.19.12
Consensus CDS ProjectCCDS20489.1
International Mouse Knockout Project StatusUsp18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030107 Ensembl Gene Model | MGI Sequence Detail 25011 C57BL/6J ±  kb
transcript ENSMUST00000032198 Ensembl | MGI Sequence Detail 1770 Not Applicable 
polypeptide ENSMUSP00000032198 Ensembl | MGI Sequence Detail 368 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
Protein Ontology PR:000017156 Ubl carboxyl-terminal hydrolase 18
References (Earliest) J:53884 Liu LQ, et al., A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation. Mol Cell Biol. 1999 Apr;19(4):3029-38
(Latest) J:207464 Basters A, et al., Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15. FEBS J. 2014 Apr;281(7):1918-28
All references(51)
Other
accession IDs
MGI:1916032, MGI:2141633

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory