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Arih1 Gene Detail
Summary
  • Symbol
    Arih1
  • Name
    ariadne RBR E3 ubiquitin protein ligase 1
  • Synonyms
    UIP77
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344363
    NCBI Gene: 23806
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:59295541-59393901 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 32.01 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1676 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344363
 protein coding gene Chr9:59295541-59395469 (-)
129S1/SvImJ ENSMUSG00200032030
 protein coding gene Chr9:56414308-56512735 (-)
A/J ENSMUSG00195034526
 protein coding gene Chr9:56121482-56219892 (-)
AKR/J ENSMUSG00220029560
 protein coding gene Chr9:56271280-56369677 (-)
BALB/cJ ENSMUSG00180017113
 protein coding gene Chr9:56236271-56334665 (-)
C3H/HeJ ENSMUSG00175019016
 protein coding gene Chr9:56248144-56346546 (-)
C57BL/6NJ ENSMUSG00215016955
 protein coding gene Chr9:56229549-56327930 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032302
 protein coding gene Chr9:56582406-56681265 (-)
CAST/EiJ ENSTCUG00005021008
 protein coding gene Chr9:56156601-56255431 (-)
CBA/J ENSMUSG00210039827
 protein coding gene Chr9:56352964-56451333 (-)
DBA/2J ENSMUSG00185038598
 protein coding gene Chr9:56374921-56473330 (-)
FVB/NJ ENSMUSG00205024544
 protein coding gene Chr9:56690782-56789172 (-)
JF1/MsJ ENSUMUG00000037686
 protein coding gene Chr9:56392303-56491053 (-)
LP/J ENSMUSG00230037322
 protein coding gene Chr9:56613919-56712316 (-)
NOD/ShiLtJ ENSMUSG00190036086
 protein coding gene Chr9:56445070-56543470 (-)
NZO/HlLtJ ENSMUSG00225027976
 protein coding gene Chr9:56662664-56761077 (-)
PWK/PhJ ENSLUMG00010030117
 protein coding gene Chr9:56347377-56446037 (-)
SPRET/EiJ ENSMSPG00010026442
 protein coding gene Chr9:57389893-57491191 (-)
WSB/EiJ ENSIUOG00005039517
 protein coding gene Chr9:55852350-55950811 (-)



Homology
more
  • Human Ortholog
    ARIH1, ariadne RBR E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARIH1, ariadne RBR E3 ubiquitin protein ligase 1
  • Synonyms
    ARI, HARI, HHARI, UBCH7BP
  • Links
    NCBI Gene ID: 25820
    UniProt: Q9Y4X5

  • Chr Location
    15q24.1; chr15:72474308-72602987 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in myeloid cells exhibit increased susceptibility to Herpesvirales infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    1
  • cDNA Data
    211
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025234 Ensembl Gene Model | MGI Sequence Detail 98361 C57BL/6J ±  kb
    transcript ENSMUST00000171975 Ensembl | MGI Sequence Detail 6971 Not Applicable  
    polypeptide ENSMUSP00000126531 Ensembl | MGI Sequence Detail 555 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 212
      cDNA 211
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2143211
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:56275 Martinez-Noel G, et al., A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. FEBS Lett. 1999 Jul 9;454(3):257-61
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory