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Arih1 Gene Detail
Summary
  • Symbol
    Arih1
  • Name
    ariadne RBR E3 ubiquitin protein ligase 1
  • Synonyms
    UIP77
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344363
    NCBI Gene: 23806
  • Gene Overview
    MyGene.info: ARIH1
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:59388258-59486618 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 32.01 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    329 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344363
 protein coding gene Chr9:59388258-59488186 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034899
 protein coding gene Chr9:58733271-58833318 (-)
A/J MGP_AJ_G0034880
 protein coding gene Chr9:56847975-56947476 (-)
AKR/J MGP_AKRJ_G0034809
 protein coding gene Chr9:58163789-58264465 (-)
BALB/cJ MGP_BALBcJ_G0034872
 protein coding gene Chr9:56586003-56687824 (-)
C3H/HeJ MGP_C3HHeJ_G0034582
 protein coding gene Chr9:58662298-58761067 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035391
 protein coding gene Chr9:60361630-60462253 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032302
 protein coding gene Chr9:56582406-56681265 (-)
CAST/EiJ MGP_CASTEiJ_G0033903
 protein coding gene Chr9:58741321-58844252 (-)
CBA/J MGP_CBAJ_G0034553
 protein coding gene Chr9:62489939-62595465 (-)
DBA/2J MGP_DBA2J_G0034712
 protein coding gene Chr9:56668531-56768331 (-)
FVB/NJ MGP_FVBNJ_G0034654
 protein coding gene Chr9:55923566-56026900 (-)
LP/J MGP_LPJ_G0034795
 protein coding gene Chr9:59038405-59141750 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034697
 protein coding gene Chr9:63916080-64027499 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035413
 protein coding gene Chr9:58166555-58273904 (-)
PWK/PhJ MGP_PWKPhJ_G0033607
 protein coding gene Chr9:56722439-56823036 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033442
 protein coding gene Chr9:58445968-58554120 (-)
WSB/EiJ MGP_WSBEiJ_G0034016
 protein coding gene Chr9:58102820-58210280 (-)



Homology
more
  • Human Ortholog
    ARIH1, ariadne RBR E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ARIH1, ariadne RBR E3 ubiquitin protein ligase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARI, HARI, HHARI, UBCH7BP
  • Links
    NCBI Gene ID: 25820
    neXtProt AC: NX_Q9Y4X5
    UniProt: Q9Y4X5

  • Chr Location
    15q24.1; chr15:72474282-72586563 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    633
  • Tissues
    1
  • cDNA Data
    211
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025234 Ensembl Gene Model | MGI Sequence Detail 98361 C57BL/6J ±  kb
    transcript ENSMUST00000171975 Ensembl | MGI Sequence Detail 6971 Not Applicable  
    polypeptide ENSMUSP00000126531 Ensembl | MGI Sequence Detail 555 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 212
      cDNA 211
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2143211
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:56275 Martinez-Noel G, et al., A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. FEBS Lett. 1999 Jul 9;454(3):257-61
    • Latest
      J:244873 Kathania M, et al., Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7. J Immunol. 2015 Mar 01;194(5):2160-7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/19/2021
    MGI 6.16     		The Jackson Laboratory