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Arih2 Gene Detail
Summary
  • Symbol
    Arih2
  • Name
    ariadne RBR E3 ubiquitin protein ligase 2
  • Synonyms
    TRIAD1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344361
    NCBI Gene: 23807
  • Gene Overview
    MyGene.info: ARIH2
Location & Maps
more
  • Sequence Map
    Chr9:108602942-108649386 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46445 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.54 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ARIH2, ariadne RBR E3 ubiquitin protein ligase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARIH2, ariadne RBR E3 ubiquitin protein ligase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARI2, TRIAD1
  • Links
    NCBI Gene ID: 10425
    neXtProt AC: NX_O95376

  • Chr Location
    3p21.31; chr3:48918821-48985541 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes altered dendritic cell physiology, enhanced liver apoptosis, and complete fetal lethality that is partially modified by genetic background. On a mixed genetic background, mice that survive past weaning succumb to a severe multiorgan inflammatory response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050668 VEGA Gene Model | MGI Sequence Detail 46445 C57BL/6J ±  kb
transcript OTTMUST00000128436 VEGA | MGI Sequence Detail 3924 Not Applicable  
polypeptide OTTMUSP00000069093 VEGA | MGI Sequence Detail 492 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    72 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 7
Other
Accession IDs
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MGI:2143135
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:56275 Martinez-Noel G, et al., A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. FEBS Lett. 1999 Jul 9;454(3):257-61
  • Latest
    J:207412 Raz V, et al., A Novel Feed-Forward Loop between ARIH2 E3-Ligase and PABPN1 Regulates Aging-Associated Muscle Degeneration. Am J Pathol. 2014 Apr;184(4):1119-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory