Arih2 MGI Mouse Gene Detail - MGI:1344361 - ariadne RBR E3 ubiquitin protein ligase 2

Symbol

Arih2
Name

ariadne RBR E3 ubiquitin protein ligase 2
Synonyms

TRIAD1

Feature Type

protein coding gene
IDs

MGI:1344361
NCBI Gene: 23807
Gene Overview

MyGene.info: ARIH2
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:108602942-108649386 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 59.54 cM
Mapping Data

2 experiments

SNPs within 2kb

72 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344361	protein coding gene	Chr9:108602942-108653681 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035309	protein coding gene	Chr9:110572504-110628523 (-)
A/J	MGP_AJ_G0035288	protein coding gene	Chr9:106518027-106569031 (-)
AKR/J	MGP_AKRJ_G0035220	protein coding gene	Chr9:109194993-109244260 (-)
BALB/cJ	MGP_BALBcJ_G0035282	protein coding gene	Chr9:106215515-106267601 (-)
C3H/HeJ	MGP_C3HHeJ_G0034992	protein coding gene	Chr9:109591793-109643938 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035802	protein coding gene	Chr9:113586342-113644718 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032700	protein coding gene	Chr9:103945971-103997193 (-)
CAST/EiJ	MGP_CASTEiJ_G0034303	protein coding gene	Chr9:109553253-109602452 (-)
CBA/J	MGP_CBAJ_G0034960	protein coding gene	Chr9:117595080-117654779 (-)
DBA/2J	MGP_DBA2J_G0035121	protein coding gene	Chr9:105976899-106025553 (-)
FVB/NJ	MGP_FVBNJ_G0035069	protein coding gene	Chr9:104743059-104792310 (-)
LP/J	MGP_LPJ_G0035197	protein coding gene	Chr9:110765716-110821004 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035108	protein coding gene	Chr9:119166636-119219638 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035823	protein coding gene	Chr9:109469350-109517785 (-)
PWK/PhJ	MGP_PWKPhJ_G0034010	protein coding gene	Chr9:106307272-106356220 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033845	protein coding gene	Chr9:109531783-109582132 (-)
WSB/EiJ	MGP_WSBEiJ_G0034424	protein coding gene	Chr9:109350101-109402749 (-)

Human Ortholog

ARIH2, ariadne RBR E3 ubiquitin protein ligase 2

Vertebrate Orthologs

10

Human Ortholog

ARIH2, ariadne RBR E3 ubiquitin protein ligase 2
Orthology source: HomoloGene, HGNC
Synonyms

ARI2, TRIAD1
Links

HGNC:690

NCBI Gene ID: 10425

neXtProt AC: NX_O95376

UniProt: O95376
Chr Location

3p21.31; chr3:48918820-48985541 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 48424
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ARIH2
Protein SuperFamily

Protein ariadne-2
Gene Tree

Arih2

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Phenotype Summary

33 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

44
Gene trapped

38
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene causes altered dendritic cell physiology, enhanced liver apoptosis, and complete fetal lethality that is partially modified by genetic background. On a mixed genetic background, mice that survive past weaning succumb to a severe multiorgan inflammatory response.

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All GO Annotations

24
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

12
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arih2

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Arih2 interacts with 292 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

82
RefSeq

17
UniProt

7
CCDS

CCDS23534.1

Ensembl

ENSMUSG00000064145 (Evidence)
NCBI Gene

23807

			Length	Strain/Species	Flank
genomic	ENSMUSG00000064145	Ensembl Gene Model \| MGI Sequence Detail	46445	C57BL/6J	± kb
transcript	ENSMUST00000013338	Ensembl \| MGI Sequence Detail	3924	Not Applicable
polypeptide	ENSMUSP00000013338	Ensembl \| MGI Sequence Detail	492	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000004272 E3 ubiquitin-protein ligase ARIH2

(term hierarchy)
EC

2.3.2.31
InterPro Domains

IPR031127 E3 ubiquitin ligase RBR family

IPR031126 E3 ubiquitin-protein ligase ARIH2

IPR002867 IBR domain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

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All nucleic 13

cDNA 13

Microarray probesets 7

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MGI:2143135

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 11
Earliest

J:56275 Martinez-Noel G, et al., A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. FEBS Lett. 1999 Jul 9;454(3):257-61
Latest

J:207412 Raz V, et al., A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration. Am J Pathol. 2014 Apr;184(4):1119-1131

TSS for Arih2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr91554	Chr9:108649660-108649671 (-)	-280 bp
Tssr91553	Chr9:108649600-108649609 (-)	-219 bp
Tssr91552	Chr9:108649564-108649569 (-)	-181 bp
Tssr91551	Chr9:108649349-108649407 (-)	8 bp
Tssr91550	Chr9:108649309-108649323 (-)	70 bp
Tssr91549	Chr9:108649291-108649306 (-)	87 bp
Tssr91548	Chr9:108649061-108649073 (-)	319 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/19/2020 MGI 6.15