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Arih2 Gene Detail
Summary
  • Symbol
    Arih2
  • Name
    ariadne RBR E3 ubiquitin protein ligase 2
  • Synonyms
    TRIAD1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344361
    NCBI Gene: 23807
  • Gene Overview
    MyGene.info: ARIH2
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108602942-108649386 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344361
 protein coding gene Chr9:108602942-108653681 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035309
 protein coding gene Chr9:110572504-110628523 (-)
A/J MGP_AJ_G0035288
 protein coding gene Chr9:106518027-106569031 (-)
AKR/J MGP_AKRJ_G0035220
 protein coding gene Chr9:109194993-109244260 (-)
BALB/cJ MGP_BALBcJ_G0035282
 protein coding gene Chr9:106215515-106267601 (-)
C3H/HeJ MGP_C3HHeJ_G0034992
 protein coding gene Chr9:109591793-109643938 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035802
 protein coding gene Chr9:113586342-113644718 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032700
 protein coding gene Chr9:103945971-103997193 (-)
CAST/EiJ MGP_CASTEiJ_G0034303
 protein coding gene Chr9:109553253-109602452 (-)
CBA/J MGP_CBAJ_G0034960
 protein coding gene Chr9:117595080-117654779 (-)
DBA/2J MGP_DBA2J_G0035121
 protein coding gene Chr9:105976899-106025553 (-)
FVB/NJ MGP_FVBNJ_G0035069
 protein coding gene Chr9:104743059-104792310 (-)
LP/J MGP_LPJ_G0035197
 protein coding gene Chr9:110765716-110821004 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035108
 protein coding gene Chr9:119166636-119219638 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035823
 protein coding gene Chr9:109469350-109517785 (-)
PWK/PhJ MGP_PWKPhJ_G0034010
 protein coding gene Chr9:106307272-106356220 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033845
 protein coding gene Chr9:109531783-109582132 (-)
WSB/EiJ MGP_WSBEiJ_G0034424
 protein coding gene Chr9:109350101-109402749 (-)



Homology
more
  • Human Ortholog
    ARIH2, ariadne RBR E3 ubiquitin protein ligase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARIH2, ariadne RBR E3 ubiquitin protein ligase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARI2, TRIAD1
  • Links
    NCBI Gene ID: 10425
    neXtProt AC: NX_O95376
    UniProt: O95376

  • Chr Location
    3p21.31; chr3:48918820-48985541 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes altered dendritic cell physiology, enhanced liver apoptosis, and complete fetal lethality that is partially modified by genetic background. On a mixed genetic background, mice that survive past weaning succumb to a severe multiorgan inflammatory response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • cDNA Data
    13
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064145 Ensembl Gene Model | MGI Sequence Detail 46445 C57BL/6J ±  kb
    transcript ENSMUST00000013338 Ensembl | MGI Sequence Detail 3924 Not Applicable  
    polypeptide ENSMUSP00000013338 Ensembl | MGI Sequence Detail 492 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2143135
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:56275 Martinez-Noel G, et al., A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. FEBS Lett. 1999 Jul 9;454(3):257-61
    • Latest
      J:207412 Raz V, et al., A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration. Am J Pathol. 2014 Apr;184(4):1119-1131
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/05/2021
    MGI 6.16     		The Jackson Laboratory