Arih2 Gene Detail

Summary

• Symbol
  Arih2
• Name
  ariadne RBR E3 ubiquitin protein ligase 2
• Synonyms
  TRIAD1

• Feature Type
  protein coding gene
• IDs
  MGI:1344361
  NCBI Gene: 23807
• Gene Overview
  MyGene.info: ARIH2
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr9:108602942-108649386 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    46445 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 59.54 cM
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  ARIH2, ariadne RBR E3 ubiquitin protein ligase 2

• Vertebrate Orthologs
  10

• Human Ortholog
  ARIH2, ariadne RBR E3 ubiquitin protein ligase 2
  Orthology source: HomoloGene, HGNC
• Synonyms
  ARI2, TRIAD1
• Links
  HGNC:690

  NCBI Gene ID: 10425

  neXtProt AC: NX_O95376

  UniProt: O95376

  
  
• Chr Location
  3p21.31; chr3:48918820-48985541 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 48424
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: ARIH2
• Protein SuperFamily
  Protein ariadne-2
• Gene Tree
  Arih2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  21 phenotypes from 2 alleles in 3 genetic backgrounds
  1 phenotype from multigenic genotypes
  11 phenotype references
  

• All Mutations and Alleles
  44
• Gene trapped
  38
• Targeted
  6
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  45 strains or lines available

Homozygous inactivation of this gene causes altered dendritic cell physiology, enhanced liver apoptosis, and complete fetal lethality that is partially modified by genetic background. On a mixed genetic background, mice that survive past weaning succumb to a severe multiorgan inflammatory response.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  25
• GO References
  5

• External Resources
  FuncBase

Expression

• cDNA Data
  11
• Literature Summary
  1

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Arih2 interacts with 292 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

Sequences &
Gene Models

• All Sequences
  75
• RefSeq
  9
• UniProt
  7
• CCDS
  CCDS23534.1

• VEGA
  OTTMUSG00000050668 (Evidence)
• Ensembl
  ENSMUSG00000064145 (Evidence)
• NCBI Gene
  23807

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000050668	VEGA Gene Model | MGI Sequence Detail	46445	C57BL/6J
transcript	OTTMUST00000128436	VEGA | MGI Sequence Detail	3924	Not Applicable
polypeptide	OTTMUSP00000069093	VEGA | MGI Sequence Detail	492	Not Applicable

Polymorphisms

• SNPs within 2kb
  72 from dbSNP Build 142

Protein
Information

• UniProt
  7 Sequences
• Protein Ontology
  PR:000004272 E3 ubiquitin-protein ligase ARIH2
  (term hierarchy)
• EC
  2.3.2.-
• InterPro Domains
  IPR031127 E3 ubiquitin ligase RBR family
  IPR002867 IBR domain
  IPR013083 Zinc finger, RING/FYVE/PHD-type
  IPR001841 Zinc finger, RING-type
  IPR017907 Zinc finger, RING-type, conserved site

Molecular
Reagents

• All nucleic 12

  cDNA 12

  
  

  Microarray probesets 7

Other
Accession IDs

MGI:2143135

References

• Summaries
  All 36

  Developmental Gene Expression 1

  Gene Ontology 5

  Phenotypes 11
• Earliest
  J:56275 Martinez-Noel G, et al., A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. FEBS Lett. 1999 Jul 9;454(3):257-61
• Latest
  J:207412 Raz V, et al., A Novel Feed-Forward Loop between ARIH2 E3-Ligase and PABPN1 Regulates Aging-Associated Muscle Degeneration. Am J Pathol. 2014 Apr;184(4):1119-31