Arih2 Gene Detail

Summary

• Symbol
  Arih2
• Name
  ariadne RBR E3 ubiquitin protein ligase 2
• Synonyms
  TRIAD1

• Feature Type
  protein coding gene
• IDs
  MGI:1344361
  NCBI Gene: 23807
• Gene Overview
  MyGene.info: ARIH2

Location & Maps

• Sequence Map
  Chr9:108602942-108649386 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    46445 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 59.54 cM
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  ARIH2, ariadne RBR E3 ubiquitin protein ligase 2

• Vertebrate Orthologs
  10

• Human Ortholog
  ARIH2, ariadne RBR E3 ubiquitin protein ligase 2
  Orthology source: HomoloGene, HGNC
• Synonyms
  ARI2, TRIAD1
• Links
  HGNC:690

  NCBI Gene ID: 10425

  neXtProt AC: NX_O95376

  
  
• Chr Location
  3p21; chr3:48918821-48985541 (+)  GRCh38.p2

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• HomoloGene
  Vertebrate Homology Class 48424
  1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  
• HCOP
  human homology predictions: ARIH2
• Protein SuperFamily
  Protein ariadne-2
• Gene Tree
  Arih2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  14 phenotypes from 2 alleles in 3 genetic backgrounds
  1 phenotype from multigenic genotypes
  11 phenotype references
  

• All Mutations and Alleles
  44
• Gene trapped
  38
• Targeted
  6
• Incidental Mutations
  Mutagenetix , APF , CvDC

Homozygous inactivation of this gene causes altered dendritic cell physiology, enhanced liver apoptosis, and complete fetal lethality that is partially modified by genetic background. On a mixed genetic background, mice that survive past weaning succumb to a severe multiorgan inflammatory response.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  34
• GO References
  7

• External Resources
  FuncBase

Expression

• cDNA Data
  11
• Literature Summary
  1

• Other Mouse Links
  Allen Institute
  GEO
• Other Vertebrate Links
  Xenbase arih2

Interactions

• Arih2 interacts with 292 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

Sequences &
Gene Models

• All Sequences
  75
• RefSeq
  9
• UniProt
  7
• CCDS
  CCDS23534.1

• VEGA
  OTTMUSG00000050668 (Evidence)
• Ensembl
  ENSMUSG00000064145 (Evidence)
• NCBI Gene
  23807

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000050668	VEGA Gene Model | MGI Sequence Detail	46445	C57BL/6J
transcript	OTTMUST00000128436	VEGA | MGI Sequence Detail	3924	Not Applicable
polypeptide	OTTMUSP00000069093	VEGA | MGI Sequence Detail	492	Not Applicable

Polymorphisms

• SNPs within 2kb
  72 from dbSNP Build 142

Protein
Information

• UniProt
  7 Sequences
• Protein Ontology
  PR:000004272 E3 ubiquitin-protein ligase ARIH2
• EC
  6.3.2.-
• InterPro Domains
  IPR031127 E3 ubiquitin ligase RBR family
  IPR002867 IBR domain
  IPR013083 Zinc finger, RING/FYVE/PHD-type
  IPR001841 Zinc finger, RING-type
  IPR017907 Zinc finger, RING-type, conserved site

Molecular
Reagents

• All nucleic 12

  cDNA 12

  
  

  Microarray probesets 7

Other
Accession IDs

MGI:2143135

References

• Summaries
  All 38

  Developmental Gene Expression 1

  Gene Ontology 7

  Phenotypes 11
• Earliest
  J:56275 Martinez-Noel G, et al., A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. FEBS Lett. 1999 Jul 9;454(3):257-61
• Latest
  J:207412 Raz V, et al., A Novel Feed-Forward Loop between ARIH2 E3-Ligase and PABPN1 Regulates Aging-Associated Muscle Degeneration. Am J Pathol. 2014 Apr;184(4):1119-31