About   Help   FAQ
Hcst
Gene Detail
Symbol

Name
ID
Hcst
hematopoietic cell signal transducer
MGI:1344360
Synonyms
DAP10, KAP10
Feature Type
protein coding gene
Genetic Map
Chromosome 7
17.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:30417717-30419854 bp, - strand
From Ensembl annotation of GRCm38

  2138 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8024  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: HCST
Gene Tree: Hcst

Human
homologs
HCST, hematopoietic cell signal transducer
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10870
neXtProt AC: NX_Q9UBK5

Human Synonyms: DAP10, KAP10, PIK3AP

Human Chr (Location): 19q13.1; chr19:35902480-35904271 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
 
Mice homozygous for a null allele exhibit osteopetrosis, decreased CD8+ T cells involved in tumor rejection, decreased uterine NK cells, and abnormal implantation site morphology.
 
Interactions
Hcst interacts with 8 markers (Mir302c, Mir325, Mir467c, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
cDNA source data(12)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: ZFIN hcst    NEW 
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000064109 (Evidence)
Entrez Gene 23900 (Evidence)
UniGene 379050
DFCI TC1587374, TC1594281
DoTS DT.87049221, DT.94293284
NIA Mouse Gene Index U028381
Consensus CDS Project CCDS39882.1
International Mouse Phenotyping Consortium Status Hcst
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064109 Ensembl Gene Model | MGI Sequence Detail 2138 C57BL/6J ±  kb
transcript ENSMUST00000075062 Ensembl | MGI Sequence Detail 437 Not Applicable 
polypeptide ENSMUSP00000074573 Ensembl | MGI Sequence Detail 79 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009861 DAP10 membrane
Protein Ontology PR:000008477 hematopoietic cell signal transducer
References
(Earliest) J:56494 Wu J, et al., An activating immunoreceptor complex formed by NKG2D and DAP10 [see comments]. Science. 1999 Jul 30;285(5428):730-2
(Latest) J:219657 Nabekura T, et al., Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation. J Exp Med. 2014 Nov 17;211(12):2455-65
All references(53)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory