About   Help   FAQ
Hcst
Gene Detail
 Symbol
Name
ID
Hcst
hematopoietic cell signal transducer
MGI:1344360
Synonyms DAP10, KAP10
Feature Type protein coding gene
Genetic Map
Chromosome 7
17.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:30417717-30419854 bp, - strand
From Ensembl annotation of GRCm38

  2138 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8024  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Hcst

Human
homologs
Human Homolog HCST, hematopoietic cell signal transducer
NCBI Gene ID 10870
neXtProt AC  NX_Q9UBK5
Human Synonyms  DAP10, KAP10, PIK3AP
Human Chr (Location)  19q13.1; chr19:35902480-35904271 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
 
Mice homozygous for a null allele exhibit osteopetrosis, decreased CD8+ T cells involved in tumor rejection, decreased uterine NK cells, and abnormal implantation site morphology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process positive regulation of phosphatidylinositol 3-kinase signaling
Component cell surface, integral component of membrane, ...
Function phosphatidylinositol 3-kinase binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(12)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000064109 (Evidence)
Entrez Gene23900 (Evidence)
UniGene379050
DFCITC1587374, TC1594281
DoTSDT.87049221, DT.94293284
NIA Mouse Gene IndexU028381
Consensus CDS ProjectCCDS39882.1
International Mouse Knockout Project StatusHcst
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064109 Ensembl Gene Model | MGI Sequence Detail 2138 C57BL/6J ±  kb
transcript ENSMUST00000075062 Ensembl | MGI Sequence Detail 437 Not Applicable 
polypeptide ENSMUSP00000074573 Ensembl | MGI Sequence Detail 79 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009861 DAP10 membrane
Protein Ontology PR:000008477 hematopoietic cell signal transducer
References (Earliest) J:56494 Wu J, et al., An activating immunoreceptor complex formed by NKG2D and DAP10 [see comments]. Science. 1999 Jul 30;285(5428):730-2
(Latest) J:205724 Wensveen FM, et al., NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via phosphatidylinositol 3-kinase. J Immunol. 2013 Aug 1;191(3):1307-15
All references(50)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory