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Dido1 Gene Detail
Summary
  • Symbol
    Dido1
  • Name
    death inducer-obliterator 1
  • Synonyms
    6720461J16Rik, D130048F08Rik, Datf1, dido, DIO-1, mKIAA0333
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344352
    NCBI Gene: 23856
  • Gene Overview
    MyGene.info: DIDO1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180657964-180709999 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 103.20 cM, cytoband H4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344352
protein coding gene Chr2:180657963-180710028 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027000
protein coding gene Chr2:187194304-187248962 (-)
A/J MGP_AJ_G0026966
protein coding gene Chr2:179502985-179555470 (-)
AKR/J MGP_AKRJ_G0026936
protein coding gene Chr2:184886143-184938567 (-)
BALB/cJ MGP_BALBcJ_G0026975
protein coding gene Chr2:179965098-180017302 (-)
C3H/HeJ MGP_C3HHeJ_G0026716
protein coding gene Chr2:185235313-185287287 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027421
protein coding gene Chr2:192595259-192650778 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024786
protein coding gene Chr2:170192625-170246185 (-)
CAST/EiJ MGP_CASTEiJ_G0026175
protein coding gene Chr2:183477519-183531763 (-)
CBA/J MGP_CBAJ_G0026693
protein coding gene Chr2:199606565-199658297 (-)
DBA/2J MGP_DBA2J_G0026831
protein coding gene Chr2:178598910-178650904 (-)
FVB/NJ MGP_FVBNJ_G0026797
protein coding gene Chr2:177213892-177266653 (-)
LP/J MGP_LPJ_G0026932
protein coding gene Chr2:187202987-187256980 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026816
protein coding gene Chr2:202197247-202250334 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027480
protein coding gene Chr2:184841545-184896509 (-)
PWK/PhJ MGP_PWKPhJ_G0025911
protein coding gene Chr2:176111926-176164449 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025711
protein coding gene Chr2:181338663-181392853 (-)
WSB/EiJ MGP_WSBEiJ_G0026247
protein coding gene Chr2:185823325-185878253 (-)



Homology
more
  • Human Ortholog
    DIDO1, death inducer-obliterator 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DIDO1, death inducer-obliterator 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BYE1, C20orf158, DATF1, DATF-1, DIDO2, DIDO3, DIO1, DIO-1, dJ885L7.8
  • Links
    NCBI Gene ID: 11083
    neXtProt AC: NX_Q9BTC0
    UniProt: Q9BTC0

  • Chr Location
    20q13.33; chr20:62877738-62937952 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Dido1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 2 alleles in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit severely reduced fertility; about one-half develop a transplantable disease characterized by anomalies in spleen, bone marrow, and peripheral blood and including anemia and various symptoms typical of myeloid dysplasia or myeloid proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038914 Ensembl Gene Model | MGI Sequence Detail 52036 C57BL/6J ±  kb
    transcript ENSMUST00000087517 Ensembl | MGI Sequence Detail 8723 Not Applicable  
    polypeptide ENSMUSP00000084794 Ensembl | MGI Sequence Detail 2256 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 23
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2443624, MGI:2444396
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:56257 Garcia-Domingo D, et al., DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development. Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7992-7
    • Latest
      J:220531 Villares R, et al., Dido mutations trigger perinatal death and generate brain abnormalities and behavioral alterations in surviving adult mice. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4803-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory