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Dido1 Gene Detail
Summary
  • Symbol
    Dido1
  • Name
    death inducer-obliterator 1
  • Synonyms
    6720461J16Rik, D130048F08Rik, Datf1, dido, DIO-1, mKIAA0333
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344352
    NCBI Gene: 23856
  • Gene Overview
    MyGene.info: DIDO1
Location & Maps
more
  • Sequence Map
    Chr2:180657964-180709999 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52036 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 103.20 cM, cytoband H4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DIDO1, death inducer-obliterator 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DIDO1, death inducer-obliterator 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BYE1, C20orf158, DATF1, DATF-1, DIDO2, DIDO3, DIO1, DIO-1, dJ885L7.8
  • Links
    NCBI Gene ID: 11083
    neXtProt AC: NX_Q9BTC0

  • Chr Location
    20q13.33; chr20:62877734-62937952 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 2 alleles in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit severely reduced fertility; about one-half develop a transplantable disease characterized by anomalies in spleen, bone marrow, and peripheral blood and including anemia and various symptoms typical of myeloid dysplasia or myeloid proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016359 VEGA Gene Model | MGI Sequence Detail 52036 C57BL/6J ±  kb
transcript OTTMUST00000039344 VEGA | MGI Sequence Detail 8723 Not Applicable  
polypeptide OTTMUSP00000017583 VEGA | MGI Sequence Detail 2256 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    137 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006479 death-inducer obliterator 1
  • PDB
  • InterPro Domains
    IPR033082 Death-inducer obliterator 1
    IPR012921 Spen paralogue and orthologue SPOC, C-terminal
    IPR003618 Transcription elongation factor S-II, central domain
    IPR011011 Zinc finger, FYVE/PHD-type
    IPR019787 Zinc finger, PHD-finger
    IPR001965 Zinc finger, PHD-type
    IPR019786 Zinc finger, PHD-type, conserved site
    IPR013083 Zinc finger, RING/FYVE/PHD-type
Molecular
Reagents
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  • All nucleic 24
    Genomic 1
    cDNA 21
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
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MGI:2443624, MGI:2444396
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:56257 Garcia-Domingo D, et al., DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development. Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7992-7
  • Latest
    J:220531 Villares R, et al., Dido mutations trigger perinatal death and generate brain abnormalities and behavioral alterations in surviving adult mice. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4803-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory