Dlg2
Gene Detail

Symbol Name ID

Dlg2 discs, large homolog 2 (Drosophila) MGI:1344351

Synonyms

A330103J02Rik, B230218P12Rik, B330007M19Rik, Chapsyn-110, Dlgh2, LOC382816, PSD93

Feature Type

protein coding gene

Genetic Map

Chromosome 7

51.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:91090706-92447003 bp, + strand From VEGA annotation of GRCm38   1356298 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1046  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: membrane-associated guanylate kinase (MAGUK) scaffold protein
Gene Tree: Dlg2

Human homologs

Human Homolog		DLG2, discs, large homolog 2 (Drosophila)
NCBI Gene ID		1740
neXtProt AC		NX_Q15700
Human Synonyms		chapsyn-110, PPP1R58, PSD93, PSD-93
Human Chr (Location)		11q14.1; chr11:83166055-85338314 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele display lower surface expression of NMDA receptor (NMDAR) subunits NR2A and NR2B in dorsal horn neurons and significantly reduced NMDAR-mediated excitatory synaptic currents and NMDAR-dependent persistent inflammatory or nerve injury-induced neuropathic pain.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	negative regulation of phosphatase activity, neuronal ion channel clustering, ...
Component	cell junction, cytoplasm, ...
Function	PDZ domain binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (112)    Tissues (42)    Images (25)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	112

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(15) Other(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000016974 (Evidence)
Ensembl Gene Model	ENSMUSG00000052572 (Evidence)
Entrez Gene	23859 (Evidence)
DFCI	TC1590671, TC1600846, TC1601638, TC1609538, TC1610439, TC1611552, TC1613214, TC1623215, TC1653897, TC1659867, TC1687355
DoTS	DT.101260688, DT.101738184, DT.40162619, DT.55120131, DT.55137821, DT.91379046, DT.91389656, DT.94184666, DT.94192384
NIA Mouse Gene Index	U008365, U008372, U167098
PDB	2WL7
Consensus CDS Project	CCDS40021.1, CCDS57562.1
International Mouse Knockout Project Status	Dlg2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016974	VEGA Gene Model | MGI Sequence Detail	1356298	C57BL/6J
transcript	OTTMUST00000041151	VEGA | MGI Sequence Detail	5278	Not Applicable
polypeptide	OTTMUSP00000018436	VEGA | MGI Sequence Detail	870	Not Applicable

All sequences(87) RefSeq(6) UniProt(5)

Polymorphisms

SNPs(6753 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008144	Guanylate kinase
InterPro	IPR020590	Guanylate kinase, conserved site
InterPro	IPR008145	Guanylate kinase/L-type calcium channel
InterPro	IPR019590	Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
InterPro	IPR016313	Membrane-associated guanylate kinase (MAGUK) scaffold protein
InterPro	IPR019583	PDZ-associated domain of NMDA receptors
InterPro	IPR001478	PDZ domain
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR011511	Variant SH3
Protein Ontology	PR:000006512	disks large 2

References

(Earliest) J:17805 Jesaitis LA, et al., Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J Cell Biol. 1994 Mar;124(6):949-61
(Latest) J:178643 Van Campenhout CA, et al., Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases. Dev Cell. 2011 Sep 13;21(3):479-91
All references(51)

Other accession IDs

MGI:1926130, MGI:2443779, MGI:2686043