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Gene Detail
discs, large homolog 2 (Drosophila)
Synonyms A330103J02Rik, B230218P12Rik, B330007M19Rik, Chapsyn-110, Dlgh2, LOC382816, PSD93
Feature Type protein coding gene
Genetic Map
Chromosome 7
51.07 cM
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
Chr7:91090706-92447003 bp, + strand
From VEGA annotation of GRCm38

  1356298 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:1046  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: membrane-associated guanylate kinase (MAGUK) scaffold protein
Gene Tree: Dlg2

Human Homolog DLG2, discs, large homolog 2 (Drosophila)
NCBI Gene ID 1740
neXtProt AC  NX_Q15700
Human Synonyms  chapsyn-110, PPP1R58, PSD93, PSD-93
Human Chr (Location)  11q14.1; chr11:83455012-85627270 (-)  GRCh38
alleles, and
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a knock-out allele display lower surface expression of NMDA receptor (NMDAR) subunits NR2A and NR2B in dorsal horn neurons and significantly reduced NMDAR-mediated excitatory synaptic currents and NMDAR-dependent persistent inflammatory or nerve injury-induced neuropathic pain.
Dlg2 interacts with 456 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (25 annotations)
Process negative regulation of phosphatase activity, neuronal ion channel clustering, ...
Component cell junction, cytoplasm, ...
Function PDZ domain binding, protein binding, ...
External Resources: FuncBase
Literature Summary: (4 records)
Data Summary: Results (112)    Tissues (42)    Images (25)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 112
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(17) cDNA(15) Other(2)
Microarray probesets(7)
Other database
VEGA Gene ModelOTTMUSG00000016974 (Evidence)
Ensembl Gene ModelENSMUSG00000052572 (Evidence)
Entrez Gene23859 (Evidence)
DFCITC1590671, TC1600846, TC1601638, TC1609538, TC1610439, TC1611552, TC1613214, TC1623215, TC1653897, TC1659867, TC1687355
DoTSDT.101260688, DT.101738184, DT.40162619, DT.55120131, DT.55137821, DT.91379046, DT.91389656, DT.94184666, DT.94192384
NIA Mouse Gene IndexU008365, U008372, U167098
Consensus CDS ProjectCCDS40021.1, CCDS57562.1
International Mouse Knockout Project StatusDlg2
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016974 VEGA Gene Model | MGI Sequence Detail 1356298 C57BL/6J ±  kb
transcript OTTMUST00000041151 VEGA | MGI Sequence Detail 5278 Not Applicable 
polypeptide OTTMUSP00000018436 VEGA | MGI Sequence Detail 870 Not Applicable 

For the selected sequences
All sequences(137) RefSeq(56) UniProt(5)
Polymorphisms SNPs within 2kb(10778 from dbSNP Build 137)
InterPro IPR008144 Guanylate kinase
InterPro IPR020590 Guanylate kinase, conserved site
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR019590 Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
InterPro IPR016313 Membrane-associated guanylate kinase (MAGUK) scaffold protein
InterPro IPR019583 PDZ-associated domain of NMDA receptors
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000006512 disks large homolog 2
References (Earliest) J:17805 Jesaitis LA, et al., Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J Cell Biol. 1994 Mar;124(6):949-61
(Latest) J:207532 Breiderhoff T, et al., Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. PLoS One. 2013;8(9):e75006
All references(57)
accession IDs
MGI:1926130, MGI:2443779, MGI:2686043

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory