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Dlg2
Gene Detail
Symbol

Name
ID
Dlg2
discs, large homolog 2 (Drosophila)
MGI:1344351
Synonyms
A330103J02Rik, B230218P12Rik, B330007M19Rik, Chapsyn-110, Dlgh2, LOC382816, PSD93
Feature Type
protein coding gene
Genetic Map
Chromosome 7
51.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:91090706-92447003 bp, + strand
From VEGA annotation of GRCm38

  1356298 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1046  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: membrane-associated guanylate kinase (MAGUK) scaffold protein
Gene Tree: Dlg2

Human
homologs
Human Homolog DLG2, discs, large homolog 2 (Drosophila)
NCBI Gene ID 1740
neXtProt AC  NX_Q15700
Human Synonyms  chapsyn-110, PPP1R58, PSD93, PSD-93
Human Chr (Location)  11q14.1; chr11:83455012-85627270 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display lower surface expression of NMDA receptor (NMDAR) subunits NR2A and NR2B in dorsal horn neurons and significantly reduced NMDAR-mediated excitatory synaptic currents and NMDAR-dependent persistent inflammatory or nerve injury-induced neuropathic pain.
 
Interactions
Dlg2 interacts with 456 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process negative regulation of phosphatase activity, neuronal ion channel clustering, ...
Component cell junction, cytoplasm, ...
Function PDZ domain binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (112)    Tissues (42)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 112
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(15) Other(2)
Microarray probesets(7)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016974 VEGA Gene Model | MGI Sequence Detail 1356298 C57BL/6J ±  kb
transcript OTTMUST00000041151 VEGA | MGI Sequence Detail 5278 Not Applicable 
polypeptide OTTMUSP00000018436 VEGA | MGI Sequence Detail 870 Not Applicable 

For the selected sequences
All sequences(137) RefSeq(56) UniProt(5)
Polymorphisms
SNPs within 2kb(10778 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008144 Guanylate kinase
InterPro IPR020590 Guanylate kinase, conserved site
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR019590 Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
InterPro IPR016313 Membrane-associated guanylate kinase (MAGUK) scaffold protein
InterPro IPR019583 PDZ-associated domain of NMDA receptors
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000006512 disks large homolog 2
References
(Earliest) J:17805 Jesaitis LA, et al., Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J Cell Biol. 1994 Mar;124(6):949-61
(Latest) J:207532 Breiderhoff T, et al., Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. PLoS One. 2013;8(9):e75006
All references(58)
Other
accession IDs
MGI:1926130, MGI:2443779, MGI:2686043

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory