About   Help   FAQ
Dlg2 Gene Detail
Summary
  • Symbol
    Dlg2
  • Name
    discs, large homolog 2 (Drosophila)
  • Synonyms
    A330103J02Rik, B230218P12Rik, B330007M19Rik, Chapsyn-110, Dlgh2, LOC382816, PSD93
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344351
    NCBI Gene: 23859
  • Gene Overview
    MyGene.info: DLG2
Location & Maps
more
  • Sequence Map
    Chr7:91090706-92449247 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1358542 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DLG2, discs large homolog 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DLG2, discs large homolog 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    chapsyn-110, PPP1R58, PSD93, PSD-93
  • Links
    NCBI Gene ID: 1740
    neXtProt AC: NX_Q15700

  • Chr Location
    11q14.1; chr11:83455012-85628534 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 3 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Dlg2
  • Incidental Mutations
Mice homozygous for a knock-out allele display lower surface expression of NMDA receptor (NMDAR) subunits NR2A and NR2B in dorsal horn neurons and significantly reduced NMDAR-mediated excitatory synaptic currents and NMDAR-dependent persistent inflammatory or nerve injury-induced neuropathic pain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016974 VEGA Gene Model | MGI Sequence Detail 1358542 C57BL/6J ±  kb
transcript OTTMUST00000041151 VEGA | MGI Sequence Detail 5278 Not Applicable  
polypeptide OTTMUSP00000018436 VEGA | MGI Sequence Detail 870 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    14441 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 15
    Other 2

    Microarray probesets 7
Other
Accession IDs
less
MGI:1926130, MGI:2443779, MGI:2686043
References
more
  • Summaries
    All 60
    Developmental Gene Expression 5
    Gene Ontology 15
    Phenotypes 40
  • Earliest
    J:17805 Jesaitis LA, et al., Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J Cell Biol. 1994 Mar;124(6):949-61
  • Latest
    J:223607 Sarnyai Z, et al., Modeling combined schizophrenia-related behavioral and metabolic phenotypes in rodents. Behav Brain Res. 2015 Jan 1;276:130-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/26/2016
MGI 6.03
The Jackson Laboratory