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Dlg2 Gene Detail
Summary
  • Symbol
    Dlg2
  • Name
    discs large MAGUK scaffold protein 2
  • Synonyms
    A330103J02Rik, B230218P12Rik, B330007M19Rik, Chapsyn-110, Dlgh2, Gm21505, LOC382816, PSD93
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344351
    NCBI Gene: 23859
  • Gene Overview
    MyGene.info: DLG2
  • Alliance
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:90476672-92449247 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 51.07 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14441 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344351
protein coding gene Chr7:90476180-92449247 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032510
protein coding gene Chr7:93553822-94996250 (+)
A/J MGP_AJ_G0032484
protein coding gene Chr7:91266035-92623800 (+)
AKR/J MGP_AKRJ_G0032420
protein coding gene Chr7:93409980-94826094 (+)
BALB/cJ MGP_BALBcJ_G0032495
protein coding gene Chr7:90915744-92292131 (+)
C3H/HeJ MGP_C3HHeJ_G0032210
protein coding gene Chr7:93805522-95206226 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032993
protein coding gene Chr7:97193223-98641842 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029988
protein coding gene Chr7:94120769-95431938 (+)
CAST/EiJ MGP_CASTEiJ_G0031537
protein coding gene Chr7:85244489-86683162 (+)
CBA/J MGP_CBAJ_G0032177
protein coding gene Chr7:100445595-101988714 (+)
DBA/2J MGP_DBA2J_G0032329
protein coding gene Chr7:89714390-91065749 (+)
FVB/NJ MGP_FVBNJ_G0032285
protein coding gene Chr7:89571597-90899104 (+)
LP/J MGP_LPJ_G0032418
protein coding gene Chr7:94806373-96245277 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032319
protein coding gene Chr7:101501727-103121707 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033015
protein coding gene Chr7:92717180-94147830 (+)
PWK/PhJ MGP_PWKPhJ_G0031255
protein coding gene Chr7:82751165-84125721 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031098
protein coding gene Chr7:80007621-81452234 (+)
WSB/EiJ MGP_WSBEiJ_G0031654
protein coding gene Chr7:93374015-94806271 (+)



Homology
more
  • Human Ortholog
    DLG2, discs large MAGUK scaffold protein 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DLG2, discs large MAGUK scaffold protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    chapsyn-110, PPP1R58, PSD93, PSD-93
  • Links
    NCBI Gene ID: 1740
    neXtProt AC: NX_Q15700
    UniProt: Q15700

  • Chr Location
    11q14.1; chr11:83455009-85628534 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display lower surface expression of NMDA receptor (NMDAR) subunits NR2A and NR2B in dorsal horn neurons and significantly reduced NMDAR-mediated excitatory synaptic currents and NMDAR-dependent persistent inflammatory or nerve injury-induced neuropathic pain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052572 Ensembl Gene Model | MGI Sequence Detail 1972576 C57BL/6J ±  kb
    transcript ENSMUST00000231777 Ensembl | MGI Sequence Detail 7813 Not Applicable  
    polypeptide ENSMUSP00000155862 Ensembl | MGI Sequence Detail 957 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1926130, MGI:2443779, MGI:2686043, MGI:5434860
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 8
      Gene Ontology 20
      Phenotypes 44
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:262606 Ali S, et al., Identification of a novel Dlg2 isoform differentially expressed in IFNbeta-producing plasmacytoid dendritic cells. BMC Genomics. 2018 Mar 12;19(1):194

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory