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Dlg2
Gene Detail
Symbol

Name
ID
Dlg2
discs, large homolog 2 (Drosophila)
MGI:1344351
Synonyms
A330103J02Rik, B230218P12Rik, B330007M19Rik, Chapsyn-110, Dlgh2, LOC382816, PSD93
Feature Type
protein coding gene
Genetic Map
Chromosome 7
51.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:91090706-92447003 bp, + strand
From VEGA annotation of GRCm38

  1356298 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1046  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DLG2
Protein SuperFamily: membrane-associated guanylate kinase (MAGUK) scaffold protein
Gene Tree: Dlg2

Human
homologs
DLG2, discs, large homolog 2 (Drosophila)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1740
neXtProt AC: NX_Q15700

Human Synonyms: chapsyn-110, PPP1R58, PSD93, PSD-93

Human Chr (Location): 11q14.1; chr11:83455012-85628534 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele display lower surface expression of NMDA receptor (NMDAR) subunits NR2A and NR2B in dorsal horn neurons and significantly reduced NMDAR-mediated excitatory synaptic currents and NMDAR-dependent persistent inflammatory or nerve injury-induced neuropathic pain.
 
Interactions
Dlg2 interacts with 455 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (112)    Tissues (42)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 112
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA DLG2 ; Xenbase dlg2 ; ZFIN dlg2    NEW 
Molecular
reagents
All nucleic(17) cDNA(15) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000016974 (Evidence)
Ensembl Gene Model ENSMUSG00000052572 (Evidence)
Entrez Gene 23859 (Evidence)
DFCI TC1601638, TC1590671, TC1600846, TC1613214, TC1611552, TC1609538, TC1610439, TC1623215, TC1687355, TC1653897, TC1659867
DoTS DT.94184666, DT.94192384, DT.91379046, DT.101260688, DT.55120131, DT.91389656, DT.55137821, DT.101738184, DT.40162619
NIA Mouse Gene Index U167098, U008365, U008372
PDB 2WL7
Consensus CDS Project CCDS40021.1, CCDS57562.1
International Mouse Phenotyping Consortium Status Dlg2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016974 VEGA Gene Model | MGI Sequence Detail 1356298 C57BL/6J ±  kb
transcript OTTMUST00000041151 VEGA | MGI Sequence Detail 5278 Not Applicable 
polypeptide OTTMUSP00000018436 VEGA | MGI Sequence Detail 870 Not Applicable 

For the selected sequences
All sequences(137) RefSeq(56) UniProt(5)
Polymorphisms
SNPs within 2kb(10778 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008144 Guanylate kinase
InterPro IPR020590 Guanylate kinase, conserved site
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR019590 Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
InterPro IPR016313 Membrane-associated guanylate kinase (MAGUK) scaffold protein
InterPro IPR019583 PDZ-associated domain of NMDA receptors
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000006512 disks large homolog 2
References
(Earliest) J:17805 Jesaitis LA, et al., Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J Cell Biol. 1994 Mar;124(6):949-61
(Latest) J:214005 Zhang M, et al., PSD-93 deletion inhibits Fyn-mediated phosphorylation of NR2B and protects against focal cerebral ischemia. Neurobiol Dis. 2014 Aug;68:104-11
All references(60)
Other
accession IDs
MGI:1926130, MGI:2443779, MGI:2686043

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory