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Dlg2 Gene Detail
Summary
  • Symbol
    Dlg2
  • Name
    discs large MAGUK scaffold protein 2
  • Synonyms
    A330103J02Rik, B230218P12Rik, B330007M19Rik, Chapsyn-110, Dlgh2, Gm21505, LOC382816, PSD93
Location & Maps
more
  • Sequence Map
    Chr7:91090706-92449247 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1358542 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 51.07 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    DLG2, discs large MAGUK scaffold protein 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DLG2, discs large MAGUK scaffold protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    chapsyn-110, PPP1R58, PSD93, PSD-93
  • Links
    NCBI Gene ID: 1740
    neXtProt AC: NX_Q15700
    UniProt: Q15700

  • Chr Location
    11q14.1; chr11:83455009-85628534 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display lower surface expression of NMDA receptor (NMDAR) subunits NR2A and NR2B in dorsal horn neurons and significantly reduced NMDAR-mediated excitatory synaptic currents and NMDAR-dependent persistent inflammatory or nerve injury-induced neuropathic pain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052572 Ensembl Gene Model | MGI Sequence Detail 1358542 C57BL/6J ±  kb
    transcript ENSMUST00000074273 Ensembl | MGI Sequence Detail 5278 Not Applicable  
    polypeptide ENSMUSP00000073885 Ensembl | MGI Sequence Detail 870 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      14441 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1926130, MGI:2443779, MGI:2686043, MGI:5434860
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 8
      Gene Ontology 17
      Phenotypes 43
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:258339 Janova H, et al., Microglia ablation alleviates myelin-associated catatonic signs in mice. J Clin Invest. 2018 Feb 1;128(2):734-745

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/03/2018
    MGI 6.12
    The Jackson Laboratory