Smc1a
Gene Detail

Symbol Name ID

Smc1a structural maintenance of chromosomes 1A MGI:1344345

Synonyms

5830426I24Rik, SB1.8, Smc1, Smc1alpha, Smc1l1, SMCB

Feature Type

protein coding gene

Genetic Map

Chromosome X

68.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

ChrX:152016428-152062694 bp, + strand From VEGA annotation of GRCm38   46267 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4597  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: SMC
Gene Tree: Smc1a

Human homologs

Human Homolog		SMC1A, structural maintenance of chromosomes 1A
NCBI Gene ID		8243
neXtProt AC		NX_Q14683
Human Synonyms		CDLS2, DXS423E, SB1.8, SMC1, SMC1alpha, SMC1L1, SMCB
Human Chr (Location)		Xp11.22-p11.21; chrX:53401070-53449618 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SMC1A

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a disruption in this gene display increased chromosomal instability, decreased cell survival, and defective S-phase checkpoint after ionizing radiation exposure.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	cell cycle, cell cycle checkpoint, ...
Component	chromosome, chromosome, centromeric region, ...
Function	ATP binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (94)    Tissues (94)    Images (7)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(17)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000019685 (Evidence)
Ensembl Gene Model	ENSMUSG00000041133 (Evidence)
Entrez Gene	24061 (Evidence)
DFCI	TC1575253, TC1739783
DoTS	DT.101708460, DT.489886, DT.94198928
NIA Mouse Gene Index	U020321
PDB	2WD5
Consensus CDS Project	CCDS30473.1
International Mouse Knockout Project Status	Smc1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019685	VEGA Gene Model | MGI Sequence Detail	46267	C57BL/6J
transcript	OTTMUST00000047121	VEGA | MGI Sequence Detail	4691	Not Applicable
polypeptide	OTTMUSP00000021286	VEGA | MGI Sequence Detail	1233	Not Applicable

All sequences(53) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(129 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003395	RecF/RecN/SMC
InterPro	IPR010935	SMCs flexible hinge
InterPro	IPR024704	Structural maintenance of chromosomes protein
Protein Ontology	PR:000015269	structural maintenance of chromosomes protein 1A

References

(Earliest) J:22947 Sultana R, et al., The mouse Sb1.8 gene located at the distal end of the X chromosome is subject to X inactivation. Hum Mol Genet. 1995 Feb;4(2):257-63
(Latest) J:185743 Cotney J, et al., Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb. Genome Res. 2012 Jun;22(6):1069-80
All references(49)

Other accession IDs

MGI:1915016