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Smc1a
Gene Detail
Symbol

Name
ID
Smc1a
structural maintenance of chromosomes 1A
MGI:1344345
Synonyms
5830426I24Rik, SB1.8, Smc1, Smc1alpha, Smc1l1, SMCB
Feature Type
protein coding gene
Genetic Map
Chromosome X
68.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:152016428-152062694 bp, + strand
From VEGA annotation of GRCm38

  46267 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4597  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: SMC
Gene Tree: Smc1a

Human
homologs
Human Homolog SMC1A, structural maintenance of chromosomes 1A
NCBI Gene ID 8243
neXtProt AC  NX_Q14683
Human Synonyms  CDLS2, DXS423E, SB1.8, SMC1, SMC1alpha, SMC1L1, SMCB
Human Chr (Location)  Xp11.22-p11.21; chrX:53374149-53422728 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SMC1A
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a disruption in this gene display increased chromosomal instability, decreased cell survival, and defective S-phase checkpoint after ionizing radiation exposure.
 
Interactions
Smc1a interacts with 165 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cell cycle, cell division, ...
Component chromosome, chromosome, centromeric region, ...
Function ATP binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (94)    Tissues (94)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000019685 (Evidence)
Ensembl Gene ModelENSMUSG00000041133 (Evidence)
Entrez Gene24061 (Evidence)
DFCITC1575253, TC1739783
DoTSDT.101708460, DT.489886, DT.94198928
NIA Mouse Gene IndexU020321
PDB2WD5
Consensus CDS ProjectCCDS30473.1
International Mouse Knockout Project StatusSmc1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019685 VEGA Gene Model | MGI Sequence Detail 46267 C57BL/6J ±  kb
transcript OTTMUST00000047121 VEGA | MGI Sequence Detail 4691 Not Applicable 
polypeptide OTTMUSP00000021286 VEGA | MGI Sequence Detail 1233 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR003395 RecF/RecN/SMC
InterPro IPR010935 SMCs flexible hinge
InterPro IPR024704 Structural maintenance of chromosomes protein
Protein Ontology PR:000015269 structural maintenance of chromosomes protein 1A
References
(Earliest) J:22947 Sultana R, et al., The mouse Sb1.8 gene located at the distal end of the X chromosome is subject to X inactivation. Hum Mol Genet. 1995 Feb;4(2):257-63
(Latest) J:204095 Remeseiro S, et al., Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Biochim Biophys Acta. 2013 Dec;1832(12):2097-102
All references(50)
Other
accession IDs
MGI:1915016

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory