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Car14
Gene Detail
Symbol

Name
ID
Car14
carbonic anhydrase 14
MGI:1344341
Synonyms
CA XIV
Feature Type
protein coding gene
Genetic Map
Chromosome 3
41.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:95897768-95904691 bp, - strand
From VEGA annotation of GRCm38

  6924 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69105  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CA14
Protein SuperFamily: carbonate dehydratase
Gene Tree: Car14

Human
homologs
CA14, carbonic anhydrase XIV
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23632
neXtProt AC: NX_Q9ULX7

Human Synonyms: CAXiV

Human Chr (Location): 1q21; chr1:150257159-150265078 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele are viable and display normal growth, health and fertility.
 
Interactions
Car14 interacts with 49 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process carbon dioxide transport, regulation of pH
Component integral component of membrane, membrane
Function carbonate dehydratase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (98)    Tissues (94)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ca14    NEW 
Molecular
reagents
All nucleic(41) cDNA(40) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022182 (Evidence)
Ensembl Gene Model ENSMUSG00000038526 (Evidence)
Entrez Gene 23831 (Evidence)
UniGene 489647
DFCI TC1582491, TC1591904, TC1620778, TC1688182
NIA Mouse Gene Index U024375
EC 4.2.1.1
PDB 1RJ5, 1RJ6
Consensus CDS Project CCDS17625.1
International Mouse Phenotyping Consortium Status Car14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022182 VEGA Gene Model | MGI Sequence Detail 6924 C57BL/6J ±  kb
transcript OTTMUST00000052679 VEGA | MGI Sequence Detail 1709 Not Applicable 
polypeptide OTTMUSP00000025013 VEGA | MGI Sequence Detail 337 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(6 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR023561 Carbonic anhydrase, alpha-class
InterPro IPR018431 Carbonic anhydrase, CA-XIV
Protein Ontology PR:000004917 carbonic anhydrase 14
References
(Earliest) J:55432 Mori K, et al., Isolation and characterization of CA XIV, a novel membrane-bound carbonic anhydrase from mouse kidney. J Biol Chem. 1999 May 28;274(22):15701-5
(Latest) J:216097 Reibring CG, et al., Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation. PLoS One. 2014;9(5):e96007
All references(42)
Other
accession IDs
MGI:2139990

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory