Wif1
Gene Detail

Symbol

Name
ID

Wif1
Wnt inhibitory factor 1
MGI:1344332

Synonyms

WIF-1

Feature Type

protein coding gene

Genetic Map

Chromosome 10
68.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:121033960-121100650 bp, + strand From VEGA annotation of GRCm38   66691 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:31430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Wif1

Human
homologs

Human Homolog		WIF1, WNT inhibitory factor 1
NCBI Gene ID		11197
neXtProt AC		NX_Q9Y5W5
Human Synonyms		WIF-1
Human Chr (Location)		12q14.3; chr12:65050624-65121566 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mice are viable and fertile but display increased susceptibility to spontaneous and induced osteosarcomas.

 
Phenotype Images(1)

Interactions

Wif1 interacts with 178 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (6 annotations)

Process	multicellular organismal development, negative regulation of Wnt signaling pathway, ...
Component	extracellular region
Function	Wnt-protein binding

External Resources: FuncBase

Expression

Literature Summary: (37 records)

Data Summary: Results (673)    Tissues (581)    Images (116)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	666
RT-PCR	7

cDNA source data(31)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(37) cDNA(31) Primer pair(5) Other(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000027724 (Evidence)
Ensembl Gene Model	ENSMUSG00000020218 (Evidence)
Entrez Gene	24117 (Evidence)
UniGene	32831
DFCI	TC1578998, TC1595629
DoTS	DT.97367650, DT.60103296
NIA Mouse Gene Index	U012100
Consensus CDS Project	CCDS24209.1
International Mouse Knockout Project Status	Wif1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027724	VEGA Gene Model | MGI Sequence Detail	66691	C57BL/6J
transcript	OTTMUST00000068607	VEGA | MGI Sequence Detail	2294	Not Applicable
polypeptide	OTTMUSP00000034727	VEGA | MGI Sequence Detail	379	Not Applicable

All sequences(39) RefSeq(4) UniProt(7)

Polymorphisms

SNPs within 2kb(322 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR003306	WIF domain
InterPro	IPR013309	Wnt inhibitory factor (WIF)-1
Protein Ontology	PR:000017421	Wnt inhibitory factor 1

References

(Earliest) J:54017 Hsieh JC, et al., A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature. 1999 Apr 1;398(6726):431-6
(Latest) J:216214 Raspopovic J, et al., Modeling digits. Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients. Science. 2014 Aug 1;345(6196):566-70
All references(68)

Other
accession IDs

MGI:2143806