Wif1 MGI Mouse Gene Detail - MGI:1344332

Symbol

Wif1
Name

Wnt inhibitory factor 1
Synonyms

WIF-1

Feature Type

protein coding gene
IDs

MGI:1344332
NCBI Gene: 24117
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr10:120869909-120936547 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 68.98 cM
Mapping Data

2 experiments

SNPs within 2kb

2012 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344332	protein coding gene	Chr10:120869865-120936555 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017779	protein coding gene	Chr10:124262781-124334962 (+)
A/J	MGP_AJ_G0017754	protein coding gene	Chr10:119325690-119393077 (+)
AKR/J	MGP_AKRJ_G0017717	protein coding gene	Chr10:122891490-122961394 (+)
BALB/cJ	MGP_BALBcJ_G0017718	protein coding gene	Chr10:119717946-119787592 (+)
C3H/HeJ	MGP_C3HHeJ_G0017542	protein coding gene	Chr10:123095936-123168584 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018173	protein coding gene	Chr10:128499099-128577012 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015853	protein coding gene	Chr10:113656112-113724976 (+)
CAST/EiJ	MGP_CASTEiJ_G0017102	protein coding gene	Chr10:123445880-123517264 (+)
CBA/J	MGP_CBAJ_G0017511	protein coding gene	Chr10:133735409-133811150 (+)
DBA/2J	MGP_DBA2J_G0017617	protein coding gene	Chr10:118458124-118525830 (+)
FVB/NJ	MGP_FVBNJ_G0017612	protein coding gene	Chr10:117445819-117513876 (+)
LP/J	MGP_LPJ_G0017691	protein coding gene	Chr10:124802718-124874958 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017641	protein coding gene	Chr10:136283368-136357365 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018213	protein coding gene	Chr10:122910303-122982424 (+)
PWK/PhJ	MGP_PWKPhJ_G0016887	protein coding gene	Chr10:118576199-118642063 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016678	protein coding gene	Chr10:121806525-121876196 (+)
WSB/EiJ	MGP_WSBEiJ_G0017163	protein coding gene	Chr10:123145996-123216255 (+)

Human Ortholog

WIF1, WNT inhibitory factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WIF1, WNT inhibitory factor 1
Synonyms

WIF-1
Links

HGNC:18081

NCBI Gene ID: 11197

UniProt: Q9Y5W5
Chr Location

12q14.3; chr12:65050626-65121305 (-) GRCh38

MGI Vertebrate Homology

Wif1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WIF1
Gene Tree

Wif1

Diseases

3 with human WIF1 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				renal cell carcinoma IDs renal cell carcinoma DOID:4450 EFO:0000681 MESH:D002292 NCI:C9385 OMIM:300854 ORDO:217071 UMLS_CUI:C0007134
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
1 images
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

5
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available

Homozygous null mice are viable and fertile but display increased susceptibility to spontaneous and induced osteosarcomas.

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1556
Tissues

667
cDNA Data

38
Literature Summary

73

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA WIF1

Xenbase wif1

ZFIN wif1

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All Sequences

41
RefSeq

2
UniProt

4
CCDS

CCDS24209.1

Ensembl

ENSMUSG00000020218 (Evidence)
NCBI Gene

24117

			Length	Strain/Species	Flank
genomic	24117	NCBI Gene Model \| MGI Sequence Detail	66639	C57BL/6J	± kb
transcript	NM_011915	RefSeq \| MGI Sequence Detail	2242	C57BL/6
polypeptide	Q9WUA1	UniProt \| EBI \| MGI Sequence Detail	379	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017421 Wnt inhibitory factor 1

(term hierarchy)
InterPro Domains

IPR050969 Developmental Signaling Modulators

IPR013032 EGF-like, conserved site

IPR000742 EGF-like domain

IPR013111 EGF-like domain, extracellular

IPR003306 WIF domain

IPR038677 WIF domain superfamily

IPR013309 Wnt inhibitory factor (WIF)-1
GlyGen

Q9WUA1 3 sites

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All nucleic 57

cDNA 38

Primer pair 12

Other 7

Microarray probesets 3

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MGI:2143806

Summaries

All 118

Developmental Gene Expression 73

Gene Ontology 5

Phenotypes 19
Earliest

J:54017 Hsieh JC, et al., A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature. 1999 Apr 1;398(6726):431-6
Latest

J:361602 Bobzin L, et al., FGFR2 directs inhibition of WNT signaling to regulate anterior fontanelle closure during skull development. Development. 2025 Jan 15;152(2):dev204264

TSS for Wif1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96010	Chr10:120869865-120869888 (+)	-32 bp
Tssr96011	Chr10:120869890-120869917 (+)	-5 bp
Tssr96012	Chr10:120869919-120869943 (+)	22 bp
Tssr96013	Chr10:120869945-120869954 (+)	41 bp
Tssr96014	Chr10:120869964-120869979 (+)	63 bp
Tssr96015	Chr10:120870049-120870058 (+)	145 bp
Tssr3380	Chr10:120870059-120870064 (+)	153 bp
Tssr96016	Chr10:120870073-120870102 (+)	179 bp
Tssr96017	Chr10:120870104-120870123 (+)	205 bp
Tssr3381	Chr10:120870133-120870136 (+)	226 bp
Tssr96018	Chr10:120870153-120870170 (+)	253 bp
Tssr96019	Chr10:120870178-120870197 (+)	279 bp
Tssr96020	Chr10:120932493-120932523 (+)	62,599 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24