Wif1 MGI Mouse Gene Detail - MGI:1344332

Symbol

Wif1
Name

Wnt inhibitory factor 1
Synonyms

WIF-1

Feature Type

protein coding gene
IDs

MGI:1344332
NCBI Gene: 24117
Gene Overview

MyGene.info: WIF1
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr10:121034004-121100642 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 68.98 cM
Mapping Data

2 experiments

SNPs within 2kb

321 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344332	protein coding gene	Chr10:121033960-121100650 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017779	protein coding gene	Chr10:124262781-124334962 (+)
A/J	MGP_AJ_G0017754	protein coding gene	Chr10:119325690-119393077 (+)
AKR/J	MGP_AKRJ_G0017717	protein coding gene	Chr10:122891490-122961394 (+)
BALB/cJ	MGP_BALBcJ_G0017718	protein coding gene	Chr10:119717946-119787592 (+)
C3H/HeJ	MGP_C3HHeJ_G0017542	protein coding gene	Chr10:123095936-123168584 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018173	protein coding gene	Chr10:128499099-128577012 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015853	protein coding gene	Chr10:113656112-113724976 (+)
CAST/EiJ	MGP_CASTEiJ_G0017102	protein coding gene	Chr10:123445880-123517264 (+)
CBA/J	MGP_CBAJ_G0017511	protein coding gene	Chr10:133735409-133811150 (+)
DBA/2J	MGP_DBA2J_G0017617	protein coding gene	Chr10:118458124-118525830 (+)
FVB/NJ	MGP_FVBNJ_G0017612	protein coding gene	Chr10:117445819-117513876 (+)
LP/J	MGP_LPJ_G0017691	protein coding gene	Chr10:124802718-124874958 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017641	protein coding gene	Chr10:136283368-136357365 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018213	protein coding gene	Chr10:122910303-122982424 (+)
PWK/PhJ	MGP_PWKPhJ_G0016887	protein coding gene	Chr10:118576199-118642063 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016678	protein coding gene	Chr10:121806525-121876196 (+)
WSB/EiJ	MGP_WSBEiJ_G0017163	protein coding gene	Chr10:123145996-123216255 (+)

Human Ortholog

WIF1, WNT inhibitory factor 1

Vertebrate Orthologs

9

Human Ortholog

WIF1, WNT inhibitory factor 1
Orthology source: HomoloGene, HGNC
Synonyms

WIF-1
Links

HGNC:18081

NCBI Gene ID: 11197

neXtProt AC: NX_Q9Y5W5

UniProt: Q9Y5W5
Chr Location

12q14.3; chr12:65050624-65121566 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 31430
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: WIF1
Gene Tree

Wif1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
1 images
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

Homozygous null mice are viable and fertile but display increased susceptibility to spontaneous and induced osteosarcomas.

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All GO Annotations

9
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1375
Tissues

617
cDNA Data

32
Literature Summary

59

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA WIF1

Xenbase wif1

ZFIN wif1

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Wif1 interacts with 178 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

41
RefSeq

2
UniProt

4
CCDS

CCDS24209.1
UniGene

32831

Ensembl

ENSMUSG00000020218 (Evidence)
NCBI Gene

24117

			Length	Strain/Species	Flank
genomic	24117	NCBI Gene Model \| MGI Sequence Detail	66639	C57BL/6J	± kb
transcript	NM_011915	RefSeq \| MGI Sequence Detail	2242	C57BL/6
polypeptide	Q9WUA1	UniProt \| EBI \| MGI Sequence Detail	379	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017421 Wnt inhibitory factor 1

(term hierarchy)
InterPro Domains

IPR013032 EGF-like, conserved site

IPR000742 EGF-like domain

IPR003306 WIF domain

IPR038677 WIF domain superfamily

IPR013309 Wnt inhibitory factor (WIF)-1

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All nucleic 41

cDNA 32

Primer pair 6

Other 3

Microarray probesets 3

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MGI:2143806

Summaries

All 98

Developmental Gene Expression 59

Gene Ontology 4

Phenotypes 15
Earliest

J:54017 Hsieh JC, et al., A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature. 1999 Apr 1;398(6726):431-6
Latest

J:293860 Becker M, et al., WIF1 Suppresses the Generation of Suprabasal Cells in Acanthotic Skin and Growth of Basal Cell Carcinomas upon Forced Overexpression. J Invest Dermatol. 2020 Aug;140(8):1556-1565.e11

TSS for Wif1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96010	Chr10:121033960-121033983 (+)	-32 bp
Tssr96011	Chr10:121033985-121034012 (+)	-5 bp
Tssr96012	Chr10:121034014-121034038 (+)	22 bp
Tssr96013	Chr10:121034040-121034049 (+)	41 bp
Tssr96014	Chr10:121034059-121034074 (+)	63 bp
Tssr96015	Chr10:121034144-121034153 (+)	145 bp
Tssr3380	Chr10:121034154-121034159 (+)	153 bp
Tssr96016	Chr10:121034168-121034197 (+)	179 bp
Tssr96017	Chr10:121034199-121034218 (+)	205 bp
Tssr3381	Chr10:121034228-121034231 (+)	226 bp
Tssr96018	Chr10:121034248-121034265 (+)	253 bp
Tssr96019	Chr10:121034273-121034292 (+)	279 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/16/2021 MGI 6.16