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Wif1
Gene Detail
Symbol

Name
ID
Wif1
Wnt inhibitory factor 1
MGI:1344332
Synonyms
WIF-1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
68.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:121033960-121100650 bp, + strand
From VEGA annotation of GRCm38

  66691 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Wif1

Human
homologs
Human Homolog WIF1, WNT inhibitory factor 1
NCBI Gene ID 11197
neXtProt AC  NX_Q9Y5W5
Human Synonyms  WIF-1
Human Chr (Location)  12q14.3; chr12:65050624-65121566 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable and fertile but display increased susceptibility to spontaneous and induced osteosarcomas.
 
Phenotype Images(1)
Interactions
Wif1 interacts with 178 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process multicellular organismal development, negative regulation of Wnt signaling pathway, ...
Component extracellular region
Function Wnt-protein binding
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (673)    Tissues (581)    Images (116)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 666
RT-PCR 7
cDNA source data(31)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(31) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027724 (Evidence)
Ensembl Gene ModelENSMUSG00000020218 (Evidence)
Entrez Gene24117 (Evidence)
UniGene32831
DFCITC1595629, TC1578998
DoTSDT.97367650, DT.60103296
NIA Mouse Gene IndexU012100
Consensus CDS ProjectCCDS24209.1
International Mouse Knockout Project StatusWif1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027724 VEGA Gene Model | MGI Sequence Detail 66691 C57BL/6J ±  kb
transcript OTTMUST00000068607 VEGA | MGI Sequence Detail 2294 Not Applicable 
polypeptide OTTMUSP00000034727 VEGA | MGI Sequence Detail 379 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(322 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR003306 WIF domain
InterPro IPR013309 Wnt inhibitory factor (WIF)-1
Protein Ontology PR:000017421 Wnt inhibitory factor 1
References
(Earliest) J:54017 Hsieh JC, et al., A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature. 1999 Apr 1;398(6726):431-6
(Latest) J:206580 Park JH, et al., Induction of WNT inhibitory factor 1 expression by Mullerian inhibiting substance/antiMullerian hormone in the Mullerian duct mesenchyme is linked to Mullerian duct regression. Dev Biol. 2014 Feb 1;386(1):227-36
All references(67)
Other
accession IDs
MGI:2143806

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory