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Wif1 Gene Detail
Summary
  • Symbol
    Wif1
  • Name
    Wnt inhibitory factor 1
  • Synonyms
    WIF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344332
    NCBI Gene: 24117
  • Gene Overview
    MyGene.info: WIF1
Location & Maps
more
  • Sequence Map
    Chr10:121033960-121100650 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      66691 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    WIF1, WNT inhibitory factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WIF1, WNT inhibitory factor 1
    Orthology source: HomoloGene
  • Synonyms
    WIF-1
  • Links
    NCBI Gene ID: 11197
    neXtProt AC: NX_Q9Y5W5

  • Chr Location
    12q14.3; chr12:65050624-65121566 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31430
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: WIF1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    1
  • Targeted
    4
  • Incidental Mutations
Homozygous null mice are viable and fertile but display increased susceptibility to spontaneous and induced osteosarcomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027724 VEGA Gene Model | MGI Sequence Detail 66691 C57BL/6J ±  kb
transcript OTTMUST00000068607 VEGA | MGI Sequence Detail 2294 Not Applicable  
polypeptide OTTMUSP00000034727 VEGA | MGI Sequence Detail 379 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    321 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 31
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143806
References
more
  • Summaries
    All 65
    Developmental Gene Expression 37
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:54017 Hsieh JC, et al., A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature. 1999 Apr 1;398(6726):431-6
  • Latest
    J:229809 Ng RC, et al., Dysregulation of Wnt inhibitory factor 1 (Wif1) expression resulted in aberrant Wnt-beta-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations. Cell Death Differ. 2014 Jun;21(6):978-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory