Wif1 MGI Mouse Gene Detail - MGI:1344332

Wif1 Gene Detail

Symbol

Wif1
Name

Wnt inhibitory factor 1
Synonyms

WIF-1

Feature Type

protein coding gene
IDs

MGI:1344332
NCBI Gene: 24117
Gene Overview

MyGene.info: WIF1

Sequence Map

Chr10:121033960-121100650 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

66691 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 68.98 cM
Mapping Data

2 experiments

Human Ortholog

WIF1, WNT inhibitory factor 1

Vertebrate Orthologs

9

Human Ortholog

WIF1, WNT inhibitory factor 1
Orthology source: HomoloGene, HGNC
Synonyms

WIF-1
Links

HGNC:18081

NCBI Gene ID: 11197

neXtProt AC: NX_Q9Y5W5
Chr Location

12q14.3; chr12:65050624-65121566 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 31430
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: WIF1
Gene Tree

Wif1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
1 images
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF

Homozygous null mice are viable and fertile but display increased susceptibility to spontaneous and induced osteosarcomas.

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All GO Annotations

6
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

673
Tissues

581
cDNA Data

31
Literature Summary

40

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

GEISHA WIF1

Xenbase wif1

ZFIN wif1

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Wif1 interacts with 178 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

29
RefSeq

2
UniProt

4
CCDS

CCDS24209.1
UniGene

32831

			Length	Strain/Species	Flank
genomic	OTTMUSG00000027724	VEGA Gene Model \| MGI Sequence Detail	66691	C57BL/6J	± kb
transcript	OTTMUST00000068607	VEGA \| MGI Sequence Detail	2294	Not Applicable
polypeptide	OTTMUSP00000034727	VEGA \| MGI Sequence Detail	379	Not Applicable

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SNPs within 2kb

321 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000017421 Wnt inhibitory factor 1
InterPro Domains

IPR013032 EGF-like, conserved site

IPR000742 EGF-like domain

IPR003306 WIF domain

IPR013309 Wnt inhibitory factor (WIF)-1

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All nucleic 37

cDNA 31

Primer pair 5

Other 1

Microarray probesets 3

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MGI:2143806

Summaries

All 68

Developmental Gene Expression 40

Gene Ontology 3

Phenotypes 9
Earliest

J:54017 Hsieh JC, et al., A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature. 1999 Apr 1;398(6726):431-6
Latest

J:232894 Hrycaj SM, et al., Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development. Cell Rep. 2015 Aug 11;12(6):903-12

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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