About   Help   FAQ
Zeb1
Gene Detail
 Symbol
Name
ID
Zeb1
zinc finger E-box binding homeobox 1
MGI:1344313
Synonyms 3110032K11Rik, AREB6, [delta]EF1, MEB1, Nil2, Tcf18, Tcf8, Tw, ZEB, Zfhep, Zfhx1a, Zfx1a
Feature Type protein coding gene
Genetic Map
Chromosome 18
4.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr18:5591860-5775467 bp, + strand
From VEGA annotation of GRCm38

  183608 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31779  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zeb1

Human
homologs
Human Homolog ZEB1, zinc finger E-box binding homeobox 1
NCBI Gene ID 6935
neXtProt AC  NX_P37275
Human Synonyms  AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
Human Chr (Location)  10p11.2; chr10:31319172-31529814 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ZEB1
Alleles
and
phenotypes
All alleles(15) : Targeted(6) Gene trapped(7) Spontaneous(1) Chemically induced(1)
 
Mutations at this locus affect thymus organization and homozygotes exhibit severe thymic T cell deficiency. Some mutations also exhibit extensive skeletal abnormalities. Homozygotes generally die at birth.
 
Human Diseases Modeled Using Mouse Zeb1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process cartilage development, cell differentiation, ...
Component cytoplasm, nucleus, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (414)    Tissues (243)    Images (97)
Theiler Stages: 2, 3, 4, 5, 10, 11, 12, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 217
In situ reporter (knock in) 155
Northern blot 27
RT-PCR 15
cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(38) Genomic(2) cDNA(33) Primer pair(1) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030924 (Evidence)
Ensembl Gene ModelENSMUSG00000024238 (Evidence)
Entrez Gene21417 (Evidence)
DFCITC1577385, TC1608363, TC1613240, TC1620482
DoTSDT.101230555, DT.110767274, DT.110767288, DT.110767342, DT.490820, DT.60100817
NIA Mouse Gene IndexU018368
Consensus CDS ProjectCCDS29039.1
International Mouse Knockout Project StatusZeb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030924 VEGA Gene Model | MGI Sequence Detail 183608 C57BL/6J ±  kb
transcript OTTMUST00000076518 VEGA | MGI Sequence Detail 5805 Not Applicable 
polypeptide OTTMUSP00000040295 VEGA | MGI Sequence Detail 1117 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(22) UniProt(10)
Polymorphisms SNPs within 2kb(842 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008598 Drought induced 19/ RING finger protein 114
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017617 zinc finger E-box-binding homeobox 1
References (Earliest) J:274 LYON MF, Twirler: a mutant affecting the inner ear of the house mouse. J Embryol Exp Morphol. 1958 Mar;6(1):105-16
(Latest) J:203329 Siles L, et al., ZEB1 imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression. Mol Cell Biol. 2013 Apr;33(7):1368-82
All references(92)
Other
accession IDs
MGD-MRK-14760, MGD-MRK-15303, MGD-MRK-19431, MGD-MRK-24149, MGI:1920415, MGI:98508, MGI:98871

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory