Zeb1
Gene Detail

Symbol Name ID

Zeb1 zinc finger E-box binding homeobox 1 MGI:1344313

Synonyms

3110032K11Rik, AREB6, [delta]EF1, MEB1, Nil2, Tcf18, Tcf8, Tw, ZEB, Zfhep, Zfhx1a, Zfx1a

Feature Type

protein coding gene

Genetic Map

Chromosome 18

4.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)

Sequence Map

Chr18:5591860-5775467 bp, + strand From VEGA annotation of GRCm38   183608 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31779  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zeb1

Human homologs

Human Homolog		ZEB1, zinc finger E-box binding homeobox 1
NCBI Gene ID		6935
neXtProt AC		NX_P37275
Human Synonyms		AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
Human Chr (Location)		10p11.2; chr10:31608101-31818742 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ZEB1

Alleles and phenotypes

All alleles(15) : Targeted(6) Gene trapped(7) Spontaneous(1) Chemically induced(1)
 

Mutations at this locus affect thymus organization and homozygotes exhibit severe thymic T cell deficiency. Some mutations also exhibit extensive skeletal abnormalities. Homozygotes generally die at birth.

 
Human Diseases Modeled Using Mouse Zeb1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (49 annotations)

Process	cartilage development, cell differentiation, ...
Component	cytoplasm, nucleus, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (218)    Tissues (114)    Images (63)
Theiler Stages: 2, 3, 4, 5, 12, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	187
In situ reporter (knock in)	3
Northern blot	13
RT-PCR	15

cDNA source data(93)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(103) Genomic(2) cDNA(98) Primer pair(1) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000030924 (Evidence)
Ensembl Gene Model	ENSMUSG00000024238 (Evidence)
Entrez Gene	21417 (Evidence)
UniGene	3929
DFCI	TC1577385, TC1608363, TC1613240, TC1620482
DoTS	DT.101230555, DT.110767274, DT.110767288, DT.110767342, DT.490820, DT.60100817
NIA Mouse Gene Index	U018368
Consensus CDS Project	CCDS29039.1
International Mouse Knockout Project Status	Zeb1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030924	VEGA Gene Model | MGI Sequence Detail	183608	C57BL/6J
transcript	OTTMUST00000076518	VEGA | MGI Sequence Detail	5805	Not Applicable
polypeptide	OTTMUSP00000040295	VEGA | MGI Sequence Detail	1117	Not Applicable

All sequences(89) RefSeq(2) UniProt(13)

Polymorphisms

SNPs(640 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000017617	zinc finger E-box-binding homeobox 1

References

(Earliest) J:274 LYON MF, Twirler: a mutant affecting the inner ear of the house mouse. J Embryol Exp Morphol. 1958 Mar;6(1):105-16
(Latest) J:185495 Arnold CN, et al., A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci U S A. 2012 Jul 3;
All references(90)

Other accession IDs

MGD-MRK-14760, MGD-MRK-15303, MGD-MRK-19431, MGD-MRK-24149, MGI:1920415, MGI:98508, MGI:98871