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Zeb1
Gene Detail
Symbol

Name
ID
Zeb1
zinc finger E-box binding homeobox 1
MGI:1344313
Synonyms
3110032K11Rik, AREB6, [delta]EF1, MEB1, Nil2, Tcf18, Tcf8, Tw, ZEB, Zfhep, Zfhx1a, Zfx1a
Feature Type
protein coding gene
Genetic Map
Chromosome 18
4.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr18:5591860-5775467 bp, + strand
From VEGA annotation of GRCm38

  183608 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31779  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ZEB1
Gene Tree: Zeb1

Human
homologs
ZEB1, zinc finger E-box binding homeobox 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6935
neXtProt AC: NX_P37275

Human Synonyms: AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A

Human Chr (Location): 10p11.2; chr10:31318783-31529814 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ZEB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Chemically induced (ENU)(2) Gene trapped(7) Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations at this locus affect thymus organization and homozygotes exhibit severe thymic T cell deficiency. Some mutations also exhibit extensive skeletal abnormalities. Homozygotes generally die at birth.
 
Human Diseases Modeled in Mice Using Zeb1 (2)    Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Zeb1 interacts with 426 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process cartilage development, cell differentiation, ...
Component cytoplasm, nucleoplasm, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (407)    Tissues (238)    Images (97)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 217
In situ reporter (knock in) 155
Northern blot 27
RT-PCR 8
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ZEB1 ; Xenbase zeb1 ; ZFIN zeb1a, zeb1b    NEW 
Molecular
reagents
All nucleic(39) Genomic(2) cDNA(34) Primer pair(1) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000030924 (Evidence)
Ensembl Gene Model ENSMUSG00000024238 (Evidence)
Entrez Gene 21417 (Evidence)
DFCI TC1577385, TC1620482, TC1608363, TC1613240
DoTS DT.60100817, DT.490820, DT.110767342, DT.110767288, DT.101230555, DT.110767274
NIA Mouse Gene Index U018368
Consensus CDS Project CCDS29039.1
International Mouse Phenotyping Consortium Status Zeb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030924 VEGA Gene Model | MGI Sequence Detail 183608 C57BL/6J ±  kb
transcript OTTMUST00000076518 VEGA | MGI Sequence Detail 5805 Not Applicable 
polypeptide OTTMUSP00000040295 VEGA | MGI Sequence Detail 1117 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(24) UniProt(9)
Polymorphisms
SNPs within 2kb(842 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008598 Drought induced 19/ RING finger protein 114
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017617 zinc finger E-box-binding homeobox 1
References
(Earliest) J:274 LYON MF, Twirler: a mutant affecting the inner ear of the house mouse. J Embryol Exp Morphol. 1958 Mar;6(1):105-16
(Latest) J:222305 Jin JZ, et al., Regional divergence of palate medial edge epithelium along the anterior to posterior axis. Int J Dev Biol. 2014;58(9):713-7
All references(99)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-14760, MGD-MRK-15303, MGD-MRK-19431, MGD-MRK-24149, MGI:1920415, MGI:98508, MGI:98871

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory