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Zeb1 Gene Detail
Summary
  • Symbol
    Zeb1
  • Name
    zinc finger E-box binding homeobox 1
  • Synonyms
    3110032K11Rik, AREB6, [delta]EF1, MEB1, Nil2, Tcf18, Tcf8, Tw, ZEB, Zfhep, Zfhx1a, Zfx1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344313
    NCBI Gene: 21417
  • Gene Overview
    MyGene.info: ZEB1
Location & Maps
more
  • Sequence Map
    Chr18:5591860-5775467 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      183608 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.42 cM
  • Mapping Data
    22 experiments
Homology
more
  • Human Ortholog
    ZEB1, zinc finger E-box binding homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZEB1, zinc finger E-box binding homeobox 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
  • Links
    NCBI Gene ID: 6935
    neXtProt AC: NX_P37275

  • Chr Location
    10p11.2; chr10:31318783-31529814 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31779
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ZEB1
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Zeb1 mouse models; 2 with human ZEB1 associations

Human Disease Mouse Models
       Corneal Dystrophy, Posterior Polymorphous, 3; PPCD3   OMIM: 609141 View 2 models
       Myelopathy, Htlv-1-Associated; HAM   OMIM: 159580 View 1 model
       Corneal Dystrophy, Fuchs Endothelial, 6; FECD6   OMIM: 613270
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    172 phenotypes from 7 alleles in 14 genetic backgrounds
    14 phenotypes from multigenic genotypes
    5 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (ENU)
    2
  • Gene trapped
    7
  • Spontaneous
    1
  • Targeted
    6
  • Incidental Mutations
Mutations at this locus affect thymus organization and homozygotes exhibit severe thymic T cell deficiency. Some mutations also exhibit extensive skeletal abnormalities. Homozygotes generally die at birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030924 VEGA Gene Model | MGI Sequence Detail 183608 C57BL/6J ±  kb
transcript OTTMUST00000076518 VEGA | MGI Sequence Detail 5805 Not Applicable  
polypeptide OTTMUSP00000040295 VEGA | MGI Sequence Detail 1117 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    841 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000017617 zinc finger E-box-binding homeobox 1
  • InterPro Domains
    IPR008598 Drought induced 19 protein type, zinc-binding domain
    IPR009057 Homeodomain-like
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 39
    Genomic 2
    cDNA 34
    Primer pair 1
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-14760, MGD-MRK-15303, MGD-MRK-19431, MGD-MRK-24149, MGI:1920415, MGI:98508, MGI:98871
References
more
  • Summaries
    All 99
    Developmental Gene Expression 28
    Diseases 2
    Gene Ontology 18
    Phenotypes 32
  • Earliest
    J:274 LYON MF, Twirler: a mutant affecting the inner ear of the house mouse. J Embryol Exp Morphol. 1958 Mar;6(1):105-16
  • Latest
    J:229091 Branco MR, et al., Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell. 2016 Jan 25;36(2):152-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory