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Zeb1 Gene Detail
Summary
  • Symbol
    Zeb1
  • Name
    zinc finger E-box binding homeobox 1
  • Synonyms
    3110032K11Rik, AREB6, [delta]EF1, MEB1, Nil2, Tcf18, Tcf8, Tw, ZEB, Zfhep, Zfhx1a, Zfx1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344313
    NCBI Gene: 21417
  • Gene Overview
    MyGene.info: ZEB1
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:5591860-5775467 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.42 cM
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    841 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344313
protein coding gene Chr18:5591860-5775468 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024127
protein coding gene Chr18:2464905-2642516 (+)
A/J MGP_AJ_G0024089
protein coding gene Chr18:2476286-2651367 (+)
AKR/J MGP_AKRJ_G0024057
protein coding gene Chr18:2499985-2681602 (+)
BALB/cJ MGP_BALBcJ_G0024089
protein coding gene Chr18:2450693-2634918 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0024534
protein coding gene Chr18:2631428-2821669 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021973
protein coding gene Chr18:2242748-2419338 (+)
CAST/EiJ MGP_CASTEiJ_G0023333
protein coding gene Chr18:2451717-2650390 (+)
CBA/J MGP_CBAJ_G0023828
protein coding gene Chr18:2599822-2798527 (+)
DBA/2J MGP_DBA2J_G0023956
protein coding gene Chr18:2397069-2577232 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0024040
protein coding gene Chr18:2548622-2711312 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023950
protein coding gene Chr18:2631843-2836058 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024579
protein coding gene Chr18:2422002-2598218 (+)
PWK/PhJ MGP_PWKPhJ_G0023078
protein coding gene Chr18:2386381-2573418 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022889
protein coding gene Chr18:2713905-2905142 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ZEB1, zinc finger E-box binding homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZEB1, zinc finger E-box binding homeobox 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
  • Links
    NCBI Gene ID: 6935
    neXtProt AC: NX_P37275
    UniProt: P37275

  • Chr Location
    10p11.22; chr10:31318495-31529814 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31779
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZEB1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Zeb1 mouse models; 1 with human ZEB1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    183 phenotypes from 9 alleles in 16 genetic backgrounds
    14 phenotypes from multigenic genotypes
    5 images
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations at this locus affect thymus organization and homozygotes exhibit severe thymic T cell deficiency. Some mutations result in eye anomalies and extensive skeletal abnormalities. Homozygotes generally die at birth due to respiratory failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024238 Ensembl Gene Model | MGI Sequence Detail 183608 C57BL/6J ±  kb
    transcript ENSMUST00000025081 Ensembl | MGI Sequence Detail 5805 Not Applicable  
    polypeptide ENSMUSP00000025081 Ensembl | MGI Sequence Detail 1117 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 2
      cDNA 35
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14760, MGD-MRK-15303, MGD-MRK-19431, MGD-MRK-24149, MGI:1920415, MGI:98508, MGI:98871
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 36
      Diseases 1
      Gene Ontology 18
      Phenotypes 37
    • Earliest
      J:274 LYON MF, Twirler: a mutant affecting the inner ear of the house mouse. J Embryol Exp Morphol. 1958 Mar;6(1):105-16
    • Latest
      J:266087 Liu Y, et al., Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells. Nat Commun. 2018 Jun 21;9(1):2424

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory