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Klk8
Gene Detail
 Symbol
Name
ID
Klk8
kallikrein related-peptidase 8
MGI:1343327
Synonyms BSP1, Nrpn, Prss19
Feature Type protein coding gene
Genetic Map
Chromosome 7
28.26 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:43797577-43803822 bp, + strand
From NCBI annotation of GRCm38

  6246 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21410  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: trypsin
Gene Tree: Klk8

Human
homologs
Human Homolog KLK8, kallikrein-related peptidase 8
NCBI Gene ID 11202
neXtProt AC  NX_O60259
Human Synonyms  HNP, NP, NRPN, PRSS19, TADG14
Human Chr (Location)  19q13; chr19:50996008-51001702 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show aberrant synapses and neurons in the hippocampus CA1 field. Homozygotes for another null allele have normal LTP and spatial reference memory but show increased polyspiking in response to repetitive afferent stimulation and enhanced kainite-induced seizure activity.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell death, keratinocyte proliferation, ...
Component cytoplasm, extracellular region, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (140)    Tissues (92)    Images (27)
Theiler Stages: 6, 9, 11, 13, 14, 15, 16, 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 111
Northern blot 28
RT-PCR 1
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(19) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000064023 (Evidence)
Entrez Gene259277 (Evidence)
UniGene458023
DFCITC1586091
NIA Mouse Gene IndexU153523
EC3.4.21.118
PDB1NPM
Consensus CDS ProjectCCDS21182.1
International Mouse Knockout Project StatusKlk8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 259277 NCBI Gene Model | MGI Sequence Detail 6246 C57BL/6J ±  kb
transcript NM_008940 RefSeq | MGI Sequence Detail 1322 C57BL/6 
polypeptide Q61955 UniProt | EBI | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(150 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000009418 kallikrein-8
Graphical View of Protein Domain Structure
References (Earliest) J:26897 Chen ZL, et al., Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus. J Neurosci. 1995 Jul;15(7 Pt 2):5088-97
(Latest) J:188758 Kishibe M, et al., Kallikrein-related peptidase 8-dependent skin wound healing is associated with upregulation of kallikrein-related peptidase 6 and PAR2. J Invest Dermatol. 2012 Jun;132(6):1717-24
All references(50)
Other
accession IDs
MGI:1202387

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory