Klk8
Gene Detail

Symbol Name ID

Klk8 kallikrein related-peptidase 8 MGI:1343327

Synonyms

BSP1, Nrpn, Prss19

Feature Type

protein coding gene

Genetic Map

Chromosome 7

28.26 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:43797577-43803822 bp, + strand From NCBI annotation of GRCm38   6246 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21410  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: trypsin
Gene Tree: Klk8

Human homologs

Human Homolog		KLK8, kallikrein-related peptidase 8
NCBI Gene ID		11202
neXtProt AC		NX_O60259
Human Synonyms		HNP, NP, NRPN, PRSS19, TADG14
Human Chr (Location)		19q13; chr19:51499264-51504958 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes for a null allele show aberrant synapses and neurons in the hippocampus CA1 field. Homozygotes for another null allele have normal LTP and spatial reference memory but show increased polyspiking in response to repetitive afferent stimulation and enhanced kainite-induced seizure activity.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cell death, keratinocyte proliferation, ...
Component	cytoplasm, extracellular region, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (140)    Tissues (92)    Images (27)
Theiler Stages: 6, 9, 11, 13, 14, 15, 16, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	111
Northern blot	28
RT-PCR	1

cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(1) cDNA(19) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000064023 (Evidence)
Entrez Gene	259277 (Evidence)
UniGene	458023
DFCI	TC1586091
NIA Mouse Gene Index	U153523
EC	3.4.21.118
PDB	1NPM
Consensus CDS Project	CCDS21182.1
International Mouse Knockout Project Status	Klk8

Sequences

Length	Strain/Species
genomic	259277	NCBI Gene Model | MGI Sequence Detail	6246	C57BL/6J
transcript	NM_008940	RefSeq | MGI Sequence Detail	1322	C57BL/6
polypeptide	Q61955	UniProt | EBI | MGI Sequence Detail	260	Not Applicable

All sequences(15) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(121 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000009418	kallikrein-8

Graphical View of Protein Domain Structure

References

(Earliest) J:26897 Chen ZL, et al., Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus. J Neurosci. 1995 Jul;15(7 Pt 2):5088-97
(Latest) J:188758 Kishibe M, et al., Kallikrein-related peptidase 8-dependent skin wound healing is associated with upregulation of kallikrein-related peptidase 6 and PAR2. J Invest Dermatol. 2012 Jun;132(6):1717-24
All references(50)

Other accession IDs

MGI:1202387