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Vgf
Gene Detail
Symbol

Name
ID
Vgf
VGF nerve growth factor inducible
MGI:1343180
Synonyms
LOC381677
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:137026392-137033351 bp, + strand
From VEGA annotation of GRCm38

  6960 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

HCOP human homology predictions: VGF
Gene Tree: Vgf

Human
homologs
VGF, VGF nerve growth factor inducible
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7425
neXtProt AC: NX_O15240

Human Synonyms: SCG7, SgVII

Human Chr (Location): 7q22.1; chr7:101162509-101169935 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation are small, lean, hyperactive, hypermetabolic, and infertile. Mutants exhibit markedly reduced leptin levels and altered hypothalamic proopiomelanocortin, neuropeptide Y, and agouti-related peptide expression.
 
Interactions
Vgf interacts with 66 markers (Mir27a, Mir27b, Mir30c-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process generation of precursor metabolites and energy, glucose homeostasis, ...
Component cell, cytoplasmic vesicle, ...
Function neuropeptide hormone activity
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000049328 (Evidence)
Ensembl Gene Model ENSMUSG00000037428 (Evidence)
Entrez Gene 381677 (Evidence)
UniGene 389697
DFCI TC1611608
DoTS DT.101356498
NIA Mouse Gene Index U164635
Consensus CDS Project CCDS19760.1
International Mouse Phenotyping Consortium Status Vgf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049328 VEGA Gene Model | MGI Sequence Detail 6960 C57BL/6J ±  kb
transcript OTTMUST00000125762 VEGA | MGI Sequence Detail 2277 Not Applicable 
polypeptide OTTMUSP00000068089 VEGA | MGI Sequence Detail 617 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(17) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026128 Neurosecretory protein VGF
Protein Ontology PR:000017289 neurosecretory protein VGF
References
(Earliest) J:56499 Hahm S, et al., Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance [see comments]. Neuron. 1999 Jul;23(3):537-48
(Latest) J:212045 Fargali S, et al., The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. FASEB J. 2014 May;28(5):2120-33
All references(32)
Other
accession IDs
MGI:2685898

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory