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Vgf
Gene Detail
 Symbol
Name
ID
Vgf
VGF nerve growth factor inducible
MGI:1343180
Synonyms LOC381677
Feature Type protein coding gene
Genetic Map
Chromosome 5
76.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:137030295-137033351 bp, + strand
From NCBI annotation of GRCm38

  3057 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Vgf

Human
homologs
Human Homolog VGF, VGF nerve growth factor inducible
NCBI Gene ID 7425
neXtProt AC  NX_O15240
Human Chr (Location)  7q22.1; chr7:101162509-101167581 (-)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation are small, lean, hyperactive, hypermetabolic, and infertile. Mutants exhibit markedly reduced leptin levels and altered hypothalamic proopiomelanocortin, neuropeptide Y, and agouti-related peptide expression.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process generation of precursor metabolites and energy, glucose homeostasis, ...
Component cell, cytoplasmic vesicle, ...
Function neuropeptide hormone activity
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000037428 (Evidence)
Entrez Gene381677 (Evidence)
UniGene389697
DFCITC1611608
DoTSDT.101356498
NIA Mouse Gene IndexU164635
Consensus CDS ProjectCCDS19760.1
International Mouse Knockout Project StatusVgf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 381677 NCBI Gene Model | MGI Sequence Detail 3057 C57BL/6J ±  kb
transcript NM_001039385 RefSeq | MGI Sequence Detail 2553 C57BL/6 
polypeptide NP_001034474 RefSeq | MGI Sequence Detail 617 C57BL/6 

For the selected sequences
All sequences(30) RefSeq(17) UniProt(1)
Polymorphisms RFLP(2) : SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026128 Neurosecretory protein VGF
Protein Ontology PR:000017289 neurosecretory protein VGF
References (Earliest) J:56499 Hahm S, et al., Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance [see comments]. Neuron. 1999 Jul;23(3):537-48
(Latest) J:198867 Cassina V, et al., Biophysical characterization of a binding site for TLQP-21, a naturally occurring peptide which induces resistance to obesity. Biochim Biophys Acta. 2013 Feb;1828(2):455-60
All references(30)
Other
accession IDs
MGI:2685898

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory