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Apobec2 Gene Detail
Summary
  • Symbol
    Apobec2
  • Name
    apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343178
    NCBI Gene: 11811
  • Gene Overview
    MyGene.info: APOBEC2
Location & Maps
more
  • Sequence Map
    Chr17:48419231-48432728 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13498 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 24.02 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    APOBEC2, apolipoprotein B mRNA editing enzyme catalytic subunit 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    APOBEC2, apolipoprotein B mRNA editing enzyme catalytic subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARCD1, ARP1
  • Links
    NCBI Gene ID: 10930
    neXtProt AC: NX_Q9Y235

  • Chr Location
    6p21.1; chr6:41053201-41064891 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Gene trapped
    9
  • Targeted
    3
Mice homozygous for a gene trapped allele display growth retardation and decreased bone mineralization and density. Mice homozygous for a knockout allele exhibit reduced body mass and a shift in muscle fiber type and develop a mild myopathy as as they age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11811 NCBI Gene Model | MGI Sequence Detail 13498 C57BL/6J ±  kb
transcript NM_009694 RefSeq | MGI Sequence Detail 1218 C57BL/6  
polypeptide Q9WV35 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    226 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    cDNA 44
    Primer pair 2

    Microarray probesets 6
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:32731 Hirano K, et al., Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48. J Biol Chem. 1996 Apr 26;271(17):9887-90
  • Latest
    J:202864 Keil KP, et al., Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract. Gene Expr Patterns. 2013 Dec;13(8):413-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory