Apobec2
Gene Detail

Symbol Name ID

Apobec2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 MGI:1343178

Feature Type

protein coding gene

Genetic Map

Chromosome 17

24.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:48419231-48432728 bp, - strand From NCBI annotation of GRCm38   13498 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Apobec2 ± 2 cM)

Gene Tree: Apobec2

Human ortholog

APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 NCBI Gene ID 10930
Human Synonyms: ARCD1, ARP1
Human Chr6:41020940-41032630 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(12) : Targeted(3) Gene trapped(9)
 

Mice homozygous for disruptions in this gene display growth retardation and decreased bone mineralization and density.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	DNA demethylation, mRNA modification, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (46)    Tissues (5)    Images (22)
Theiler Stages: 14, 16, 23

Assay Type	Results
RNA in situ	45
RT-PCR	1

cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) cDNA(41) Primer pair(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000040694 (Evidence)
Entrez Gene	11811 (Evidence)
UniGene	482103
DFCI	TC1579727
DoTS	DT.535402
NIA Mouse Gene Index	U037899
EC	3.5.4.-
PDB	2RPZ
Consensus CDS Project	CCDS28868.1
International Mouse Knockout Project Status	Apobec2

Sequences

Length	Strain/Species
genomic	11811	NCBI Gene Model | MGI Sequence Detail	13498	C57BL/6J
transcript	NM_009694	RefSeq | MGI Sequence Detail	1218	C57BL/6
polypeptide	Q9WV35	UniProt | EBI | MGI Sequence Detail	224	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

PCR(1) : SNPs(75 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013158	APOBEC-like, N-terminal
InterPro	IPR016193	Cytidine deaminase-like
Protein Ontology	PR:000031687	probable C->U-editing enzyme APOBEC-2

Graphical View of Protein Domain Structure

References

(Earliest) J:32731 Hirano K, et al., Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48. J Biol Chem. 1996 Apr 26;271(17):9887-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)