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Apobec2
Gene Detail
 Symbol
Name
ID
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
MGI:1343178
Feature Type protein coding gene
Genetic Map
Chromosome 17
24.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:48419231-48432728 bp, - strand
From NCBI annotation of GRCm38

  13498 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4941  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Apobec2

Human
homologs
Human Homolog APOBEC2, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
NCBI Gene ID 10930
neXtProt AC  NX_Q9Y235
Human Synonyms  ARCD1, ARP1
Human Chr (Location)  6p21; chr6:41053201-41064891 (+)  GRCh38
Alleles
and
phenotypes
All alleles(12) : Gene trapped(9) Targeted(3)
 
Mice homozygous for disruptions in this gene display growth retardation and decreased bone mineralization and density.
 
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process DNA demethylation, mRNA modification, ...
Function 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity, archaeal-specific GTP cyclohydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (46)    Tissues (5)    Images (22)
Theiler Stages: 14, 16, 23
Assay TypeResults
RNA in situ 45
RT-PCR 1
cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(46) cDNA(44) Primer pair(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000040694 (Evidence)
Entrez Gene11811 (Evidence)
UniGene281793
DFCITC1579727
DoTSDT.535402
NIA Mouse Gene IndexU037899
EC3.5.4.-
PDB2RPZ
Consensus CDS ProjectCCDS28868.1
International Mouse Knockout Project StatusApobec2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11811 NCBI Gene Model | MGI Sequence Detail 13498 C57BL/6J ±  kb
transcript NM_009694 RefSeq | MGI Sequence Detail 1218 C57BL/6 
polypeptide Q9WV35 UniProt | EBI | MGI Sequence Detail 224 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(231 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013158 APOBEC-like, N-terminal
InterPro IPR016193 Cytidine deaminase-like
Protein Ontology PR:000031687 probable C->U-editing enzyme APOBEC-2
Graphical View of Protein Domain Structure
References (Earliest) J:32731 Hirano K, et al., Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48. J Biol Chem. 1996 Apr 26;271(17):9887-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory